Reviewed,
UniProtKB/Swiss-Prot Q8ZBU2 (GSH1_YERPE)
Last modified
June 16, 2009.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Glutamate--cysteine ligase EC=6.3.2.2 Alternative name(s): Gamma-glutamylcysteine synthetase Gamma-ECS Short name=GCS | ||||
| Gene names |
| ||||
| Organism | Yersinia pestis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 632 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia |
Protein attributes
| Sequence length | 519 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. HAMAP MF_00578 |
| Pathway | Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. HAMAP MF_00578 |
| Sequence similarities | Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glutathione biosynthesis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glutathione biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glutamate-cysteine ligase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 519 | 519 | Glutamate--cysteine ligase HAMAP MF_00578 | PRO_0000192547 | |||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| AL590842 Genomic DNA. Translation: CAL21892.1. AE009952 Genomic DNA. Translation: AAM84471.1. Different initiation. AE017042 Genomic DNA. Translation: AAS60658.1. Different initiation. | |
| PIR | AI0400. |
| RefSeq | NP_668220.1. NP_991781.1. YP_002348197.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1145834. 1176117. 2764400. |
| GenomeReviews | Gene locus y0887 in contig AE009952_GR. Gene locus YP_0385 in contig AE017042_GR. Gene locus YPO3301 in contig AL590842_GR. |
| KEGG | ype:YPO3301. ypk:y0887. ypm:YP_0385. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q8ZBU2. |
| OMA | Q8ZBU2. EYIEVRA. |
Enzyme and pathway databases | |
| BioCyc | YPES187410:Y0887-MON. YPES214092:YPO3301-MON. YPES229193:YP0385-MON. |
| BRENDA | 6.3.2.2. 142588. |
Family and domain databases | |
| HAMAP | MF_00578. [Tree] |
| InterPro | IPR007370. Glu_cys_ligase. IPR006334. Glut_cys_ligase. [Graphical view] |
| Pfam | PF04262. Glu_cys_ligase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01434. glu_cys_ligase. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | GSH1_YERPE | ||||||||
| Accession | Primary (citable) accession number: Q8ZBU2 Secondary accession number(s): Q0WBZ1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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