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Protein

Pantothenate synthetase

Gene

panC

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Proton donorUniRule annotation1
Binding sitei61Beta-alanineUniRule annotation1
Binding sitei61PantoateUniRule annotation1
Binding sitei155PantoateUniRule annotation1
Binding sitei178ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37ATPUniRule annotation8
Nucleotide bindingi149 – 152ATPUniRule annotation4
Nucleotide bindingi186 – 189ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:YPO3402, y0785, YP_0283
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001282951 – 284Pantothenate synthetaseAdd BLAST284

Proteomic databases

PRIDEiQ8ZBK7.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi187410.y0785.

Structurei

Secondary structure

1284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 4Combined sources3
Helixi7 – 19Combined sources13
Beta strandi24 – 29Combined sources6
Helixi35 – 45Combined sources11
Beta strandi48 – 55Combined sources8
Helixi59 – 61Combined sources3
Helixi65 – 70Combined sources6
Helixi75 – 84Combined sources10
Beta strandi88 – 91Combined sources4
Helixi95 – 98Combined sources4
Beta strandi108 – 110Combined sources3
Turni112 – 114Combined sources3
Beta strandi115 – 117Combined sources3
Helixi119 – 122Combined sources4
Helixi126 – 141Combined sources16
Beta strandi144 – 149Combined sources6
Helixi153 – 166Combined sources14
Beta strandi171 – 175Combined sources5
Helixi188 – 192Combined sources5
Helixi195 – 200Combined sources6
Helixi203 – 216Combined sources14
Helixi222 – 236Combined sources15
Beta strandi244 – 247Combined sources4
Turni248 – 250Combined sources3
Beta strandi260 – 269Combined sources10
Beta strandi272 – 281Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q10X-ray1.83A/B/C/D1-284[»]
3Q12X-ray1.58A/B/C/D1-284[»]
ProteinModelPortaliQ8ZBK7.
SMRiQ8ZBK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IAA. Bacteria.
COG0414. LUCA.
HOGENOMiHOG000175516.
KOiK01918.
OMAiENVDCIF.

Family and domain databases

CDDicd00560. PanC. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC. 1 hit.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZBK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIIETLPLL RQQIRRWRQE GKRIALVPTM GNLHEGHMTL VDEAKTRADV
60 70 80 90 100
VVVTIFVNPL QFERPDDLAH YPRTLQEDCE KLTRHGADLV FAPAAADIYP
110 120 130 140 150
AGLEKQTYVD VPALSTILEG ASRPGHFRGV STIVSKLFNL IQPDVACFGE
160 170 180 190 200
KDYQQLALIR KMVADMGYDI NIVGVPTVRA KDGLALSSRN GYLTEEERQI
210 220 230 240 250
APQLSKIMWA LAEKMALGER QIDALLEEAA AQLLRVGFTP DELFIRDAET
260 270 280
LQPLTVDSQQ AVILMAAWLG KARLIDNQLV DLRH
Length:284
Mass (Da):31,772
Last modified:March 1, 2002 - v1
Checksum:i6F589341B134FA7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21991.1.
AE009952 Genomic DNA. Translation: AAM84372.1.
AE017042 Genomic DNA. Translation: AAS60558.1.
PIRiAD0413.
RefSeqiWP_002209348.1. NZ_LQBA01000021.1.
YP_002348294.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84372; AAM84372; y0785.
AAS60558; AAS60558; YP_0283.
GeneIDi1176219.
KEGGiype:YPO3402.
ypj:CH55_1982.
ypk:y0785.
ypl:CH46_1688.
ypm:YP_0283.
ypv:BZ15_120.
ypw:CH59_2646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21991.1.
AE009952 Genomic DNA. Translation: AAM84372.1.
AE017042 Genomic DNA. Translation: AAS60558.1.
PIRiAD0413.
RefSeqiWP_002209348.1. NZ_LQBA01000021.1.
YP_002348294.1. NC_003143.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q10X-ray1.83A/B/C/D1-284[»]
3Q12X-ray1.58A/B/C/D1-284[»]
ProteinModelPortaliQ8ZBK7.
SMRiQ8ZBK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187410.y0785.

Proteomic databases

PRIDEiQ8ZBK7.

Protocols and materials databases

DNASUi1145732.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM84372; AAM84372; y0785.
AAS60558; AAS60558; YP_0283.
GeneIDi1176219.
KEGGiype:YPO3402.
ypj:CH55_1982.
ypk:y0785.
ypl:CH46_1688.
ypm:YP_0283.
ypv:BZ15_120.
ypw:CH59_2646.

Phylogenomic databases

eggNOGiENOG4108IAA. Bacteria.
COG0414. LUCA.
HOGENOMiHOG000175516.
KOiK01918.
OMAiENVDCIF.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Family and domain databases

CDDicd00560. PanC. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC. 1 hit.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPANC_YERPE
AccessioniPrimary (citable) accession number: Q8ZBK7
Secondary accession number(s): Q0WBP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.