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Protein

Pantothenate synthetase

Gene

panC

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathway: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton donorUniRule annotation
Binding sitei61 – 611Beta-alanineUniRule annotation
Binding sitei61 – 611PantoateUniRule annotation
Binding sitei155 – 1551PantoateUniRule annotation
Binding sitei178 – 1781ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATPUniRule annotation
Nucleotide bindingi149 – 1524ATPUniRule annotation
Nucleotide bindingi186 – 1894ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3356-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:YPO3402, y0785, YP_0283
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815 Componenti: Chromosome UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Pantothenate synthetasePRO_0000128295Add
BLAST

Proteomic databases

PRIDEiQ8ZBK7.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi214092.YPO3402.

Structurei

Secondary structure

1
284
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 43Combined sources
Helixi7 – 1913Combined sources
Beta strandi24 – 296Combined sources
Helixi35 – 4511Combined sources
Beta strandi48 – 558Combined sources
Helixi59 – 613Combined sources
Helixi65 – 706Combined sources
Helixi75 – 8410Combined sources
Beta strandi88 – 914Combined sources
Helixi95 – 984Combined sources
Beta strandi108 – 1103Combined sources
Turni112 – 1143Combined sources
Beta strandi115 – 1173Combined sources
Helixi119 – 1224Combined sources
Helixi126 – 14116Combined sources
Beta strandi144 – 1496Combined sources
Helixi153 – 16614Combined sources
Beta strandi171 – 1755Combined sources
Helixi188 – 1925Combined sources
Helixi195 – 2006Combined sources
Helixi203 – 21614Combined sources
Helixi222 – 23615Combined sources
Beta strandi244 – 2474Combined sources
Turni248 – 2503Combined sources
Beta strandi260 – 26910Combined sources
Beta strandi272 – 28110Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q10X-ray1.83A/B/C/D1-284[»]
3Q12X-ray1.58A/B/C/D1-284[»]
ProteinModelPortaliQ8ZBK7.
SMRiQ8ZBK7. Positions 1-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiENVDCIF.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZBK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIIETLPLL RQQIRRWRQE GKRIALVPTM GNLHEGHMTL VDEAKTRADV
60 70 80 90 100
VVVTIFVNPL QFERPDDLAH YPRTLQEDCE KLTRHGADLV FAPAAADIYP
110 120 130 140 150
AGLEKQTYVD VPALSTILEG ASRPGHFRGV STIVSKLFNL IQPDVACFGE
160 170 180 190 200
KDYQQLALIR KMVADMGYDI NIVGVPTVRA KDGLALSSRN GYLTEEERQI
210 220 230 240 250
APQLSKIMWA LAEKMALGER QIDALLEEAA AQLLRVGFTP DELFIRDAET
260 270 280
LQPLTVDSQQ AVILMAAWLG KARLIDNQLV DLRH
Length:284
Mass (Da):31,772
Last modified:March 1, 2002 - v1
Checksum:i6F589341B134FA7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21991.1.
AE009952 Genomic DNA. Translation: AAM84372.1.
AE017042 Genomic DNA. Translation: AAS60558.1.
PIRiAD0413.
RefSeqiNP_668121.1. NC_004088.1.
NP_991681.1. NC_005810.1.
WP_002209348.1. NZ_KN150724.1.
YP_002348294.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84372; AAM84372; y0785.
AAS60558; AAS60558; YP_0283.
GeneIDi1176219.
KEGGiype:YPO3402.
ypk:y0785.
ypm:YP_0283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL21991.1.
AE009952 Genomic DNA. Translation: AAM84372.1.
AE017042 Genomic DNA. Translation: AAS60558.1.
PIRiAD0413.
RefSeqiNP_668121.1. NC_004088.1.
NP_991681.1. NC_005810.1.
WP_002209348.1. NZ_KN150724.1.
YP_002348294.1. NC_003143.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q10X-ray1.83A/B/C/D1-284[»]
3Q12X-ray1.58A/B/C/D1-284[»]
ProteinModelPortaliQ8ZBK7.
SMRiQ8ZBK7. Positions 1-282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214092.YPO3402.

Proteomic databases

PRIDEiQ8ZBK7.

Protocols and materials databases

DNASUi1145732.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM84372; AAM84372; y0785.
AAS60558; AAS60558; YP_0283.
GeneIDi1176219.
KEGGiype:YPO3402.
ypk:y0785.
ypm:YP_0283.

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiENVDCIF.
OrthoDBiEOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.
BioCyciYPES214092:GKDD-3356-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiPANC_YERPE
AccessioniPrimary (citable) accession number: Q8ZBK7
Secondary accession number(s): Q0WBP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2002
Last modified: June 24, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.