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Q8ZBK7

- PANC_YERPE

UniProt

Q8ZBK7 - PANC_YERPE

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Protein

Pantothenate synthetase

Gene
panC, YPO3402, y0785, YP_0283
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton donor By similarity
Binding sitei61 – 611Beta-alanine By similarity
Binding sitei61 – 611Pantoate By similarity
Binding sitei155 – 1551Pantoate By similarity
Binding sitei178 – 1781ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATP By similarity
Nucleotide bindingi149 – 1524ATP By similarity
Nucleotide bindingi186 – 1894ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3356-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:YPO3402, y0785, YP_0283
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Pantothenate synthetaseUniRule annotationPRO_0000128295Add
BLAST

Proteomic databases

PRIDEiQ8ZBK7.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi214092.YPO3402.

Structurei

Secondary structure

1
284
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 43
Helixi7 – 1913
Beta strandi24 – 296
Helixi35 – 4511
Beta strandi48 – 558
Helixi59 – 613
Helixi65 – 706
Helixi75 – 8410
Beta strandi88 – 914
Helixi95 – 984
Beta strandi108 – 1103
Turni112 – 1143
Beta strandi115 – 1173
Helixi119 – 1224
Helixi126 – 14116
Beta strandi144 – 1496
Helixi153 – 16614
Beta strandi171 – 1755
Helixi188 – 1925
Helixi195 – 2006
Helixi203 – 21614
Helixi222 – 23615
Beta strandi244 – 2474
Turni248 – 2503
Beta strandi260 – 26910
Beta strandi272 – 28110

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q10X-ray1.83A/B/C/D1-284[»]
3Q12X-ray1.58A/B/C/D1-284[»]
ProteinModelPortaliQ8ZBK7.
SMRiQ8ZBK7. Positions 1-282.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiECPIVRE.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZBK7-1 [UniParc]FASTAAdd to Basket

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MLIIETLPLL RQQIRRWRQE GKRIALVPTM GNLHEGHMTL VDEAKTRADV    50
VVVTIFVNPL QFERPDDLAH YPRTLQEDCE KLTRHGADLV FAPAAADIYP 100
AGLEKQTYVD VPALSTILEG ASRPGHFRGV STIVSKLFNL IQPDVACFGE 150
KDYQQLALIR KMVADMGYDI NIVGVPTVRA KDGLALSSRN GYLTEEERQI 200
APQLSKIMWA LAEKMALGER QIDALLEEAA AQLLRVGFTP DELFIRDAET 250
LQPLTVDSQQ AVILMAAWLG KARLIDNQLV DLRH 284
Length:284
Mass (Da):31,772
Last modified:March 1, 2002 - v1
Checksum:i6F589341B134FA7F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL21991.1.
AE009952 Genomic DNA. Translation: AAM84372.1.
AE017042 Genomic DNA. Translation: AAS60558.1.
PIRiAD0413.
RefSeqiNP_668121.1. NC_004088.1.
NP_991681.1. NC_005810.1.
YP_002348294.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84372; AAM84372; y0785.
AAS60558; AAS60558; YP_0283.
GeneIDi1145732.
1176219.
2766926.
KEGGiype:YPO3402.
ypk:y0785.
ypm:YP_0283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL21991.1 .
AE009952 Genomic DNA. Translation: AAM84372.1 .
AE017042 Genomic DNA. Translation: AAS60558.1 .
PIRi AD0413.
RefSeqi NP_668121.1. NC_004088.1.
NP_991681.1. NC_005810.1.
YP_002348294.1. NC_003143.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3Q10 X-ray 1.83 A/B/C/D 1-284 [» ]
3Q12 X-ray 1.58 A/B/C/D 1-284 [» ]
ProteinModelPortali Q8ZBK7.
SMRi Q8ZBK7. Positions 1-282.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214092.YPO3402.

Proteomic databases

PRIDEi Q8ZBK7.

Protocols and materials databases

DNASUi 1145732.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM84372 ; AAM84372 ; y0785 .
AAS60558 ; AAS60558 ; YP_0283 .
GeneIDi 1145732.
1176219.
2766926.
KEGGi ype:YPO3402.
ypk:y0785.
ypm:YP_0283.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi ECPIVRE.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci YPES214092:GKDD-3356-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiPANC_YERPE
AccessioniPrimary (citable) accession number: Q8ZBK7
Secondary accession number(s): Q0WBP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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