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Q8ZBG8

- OTC_YERPE

UniProt

Q8ZBG8 - OTC_YERPE

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Protein

Ornithine carbamoyltransferase

Gene

argI

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Carbamoyl phosphateUniRule annotation
Sitei31 – 311Important for structural integrityUniRule annotation
Binding sitei72 – 721Carbamoyl phosphateUniRule annotation
Binding sitei83 – 831Carbamoyl phosphateUniRule annotation
Binding sitei107 – 1071Carbamoyl phosphateUniRule annotation
Sitei147 – 1471Important for structural integrityUniRule annotation
Binding sitei168 – 1681OrnithineBy similarity
Binding sitei232 – 2321OrnithineBy similarity
Binding sitei302 – 3021Carbamoyl phosphateUniRule annotation
Binding sitei320 – 3201Carbamoyl phosphateUniRule annotation

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. ornithine carbamoyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3401-MONOMER.
UniPathwayiUPA00068; UER00112.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferaseUniRule annotation (EC:2.1.3.3UniRule annotation)
Short name:
OTCaseUniRule annotation
Gene namesi
Name:argIUniRule annotation
Ordered Locus Names:YPO3446, y0740, YP_0638
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Ornithine carbamoyltransferasePRO_0000113059Add
BLAST

Proteomic databases

PRIDEiQ8ZBG8.

Interactioni

Protein-protein interaction databases

IntActiQ8ZBG8. 1 interaction.
STRINGi214092.YPO3446.

Structurei

3D structure databases

ProteinModelPortaliQ8ZBG8.
SMRiQ8ZBG8. Positions 4-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni56 – 605Carbamoyl phosphate bindingUniRule annotation
Regioni134 – 1374Carbamoyl phosphate bindingUniRule annotation
Regioni236 – 2372Ornithine bindingUniRule annotation
Regioni273 – 2764Carbamoyl phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0078.
HOGENOMiHOG000022686.
KOiK00611.
OMAiYQRHFLR.
OrthoDBiEOG690MGV.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZBG8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQFYKRHFL RLLDFTPAEI IALLDLATEL KKDKKSGCEQ QKLVGKNIAL
60 70 80 90 100
IFEKDSTRTR CSFEVAAYDQ GARVTYLGPG GSQIGHKESI KDTARVLGRM
110 120 130 140 150
YDGIQYRGYG QRVVETLAEF AGVPVWNGLT DEFHPTQLLA DLLTMREHLP
160 170 180 190 200
NKSLNKMTLA YLGDTRNNMG NSLLEAAALV GMDLRLVAPK ACWPEEAFVI
210 220 230 240 250
SCQALAQKTG GKITLTEDIA EGVNGADFLY TDVWVSMGEP KEVWQERINL
260 270 280 290 300
LKPYQVNMRV LTLTGNPQVK FLHCLPAFHD DQTTIGKQMA EQYDLPGGME
310 320 330
VTEEVFESAH SIVFDQAENR LHTIKAVMVA TMSKI
Length:335
Mass (Da):37,478
Last modified:March 1, 2002 - v1
Checksum:i1A135B27870FB2C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL22035.1.
AE009952 Genomic DNA. Translation: AAM84327.1.
AE017042 Genomic DNA. Translation: AAS60906.1.
PIRiAH0418.
RefSeqiNP_668076.1. NC_004088.1.
NP_992029.1. NC_005810.1.
YP_002348337.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84327; AAM84327; y0740.
AAS60906; AAS60906; YP_0638.
GeneIDi1145687.
1176264.
2763679.
KEGGiype:YPO3446.
ypk:y0740.
ypm:YP_0638.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL22035.1 .
AE009952 Genomic DNA. Translation: AAM84327.1 .
AE017042 Genomic DNA. Translation: AAS60906.1 .
PIRi AH0418.
RefSeqi NP_668076.1. NC_004088.1.
NP_992029.1. NC_005810.1.
YP_002348337.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZBG8.
SMRi Q8ZBG8. Positions 4-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8ZBG8. 1 interaction.
STRINGi 214092.YPO3446.

Proteomic databases

PRIDEi Q8ZBG8.

Protocols and materials databases

DNASUi 1145687.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM84327 ; AAM84327 ; y0740 .
AAS60906 ; AAS60906 ; YP_0638 .
GeneIDi 1145687.
1176264.
2763679.
KEGGi ype:YPO3446.
ypk:y0740.
ypm:YP_0638.

Phylogenomic databases

eggNOGi COG0078.
HOGENOMi HOG000022686.
KOi K00611.
OMAi YQRHFLR.
OrthoDBi EOG690MGV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00112 .
BioCyci YPES214092:GKDD-3401-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1370. 2 hits.
HAMAPi MF_01109. OTCase.
InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view ]
Pfami PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view ]
PRINTSi PR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMi SSF53671. SSF53671. 1 hit.
TIGRFAMsi TIGR00658. orni_carb_tr. 1 hit.
PROSITEi PS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiOTC_YERPE
AccessioniPrimary (citable) accession number: Q8ZBG8
Secondary accession number(s): Q0WBK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3