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Protein

Ornithine carbamoyltransferase

Gene

argI

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argI), Ornithine carbamoyltransferase (argI)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei83Carbamoyl phosphateUniRule annotation1
Binding sitei107Carbamoyl phosphateUniRule annotation1
Binding sitei168OrnithineUniRule annotation1
Binding sitei232OrnithineUniRule annotation1
Binding sitei320Carbamoyl phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00112

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferaseUniRule annotation (EC:2.1.3.3UniRule annotation)
Short name:
OTCaseUniRule annotation
Gene namesi
Name:argIUniRule annotation
Ordered Locus Names:YPO3446, y0740, YP_0638
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001130591 – 335Ornithine carbamoyltransferaseAdd BLAST335

Proteomic databases

PaxDbiQ8ZBG8
PRIDEiQ8ZBG8

Interactioni

Protein-protein interaction databases

IntActiQ8ZBG8, 1 interactor
STRINGi187410.y0740

Structurei

3D structure databases

ProteinModelPortaliQ8ZBG8
SMRiQ8ZBG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 59Carbamoyl phosphate bindingUniRule annotation4
Regioni134 – 137Carbamoyl phosphate bindingUniRule annotation4
Regioni236 – 237Ornithine bindingUniRule annotation2
Regioni274 – 275Carbamoyl phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DBV Bacteria
COG0078 LUCA
HOGENOMiHOG000022686
KOiK00611
OMAiNPFYKRH

Family and domain databases

Gene3Di3.40.50.1370, 3 hits
HAMAPiMF_01109 OTCase, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
IPR002292 Orn/put_carbamltrans
IPR024904 OTCase_ArgI
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00102 OTCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00658 orni_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZBG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQFYKRHFL RLLDFTPAEI IALLDLATEL KKDKKSGCEQ QKLVGKNIAL
60 70 80 90 100
IFEKDSTRTR CSFEVAAYDQ GARVTYLGPG GSQIGHKESI KDTARVLGRM
110 120 130 140 150
YDGIQYRGYG QRVVETLAEF AGVPVWNGLT DEFHPTQLLA DLLTMREHLP
160 170 180 190 200
NKSLNKMTLA YLGDTRNNMG NSLLEAAALV GMDLRLVAPK ACWPEEAFVI
210 220 230 240 250
SCQALAQKTG GKITLTEDIA EGVNGADFLY TDVWVSMGEP KEVWQERINL
260 270 280 290 300
LKPYQVNMRV LTLTGNPQVK FLHCLPAFHD DQTTIGKQMA EQYDLPGGME
310 320 330
VTEEVFESAH SIVFDQAENR LHTIKAVMVA TMSKI
Length:335
Mass (Da):37,478
Last modified:March 1, 2002 - v1
Checksum:i1A135B27870FB2C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL22035.1
AE009952 Genomic DNA Translation: AAM84327.1
AE017042 Genomic DNA Translation: AAS60906.1
PIRiAH0418
RefSeqiWP_002209302.1, NZ_PDBR01000021.1
YP_002348337.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM84327; AAM84327; y0740
AAS60906; AAS60906; YP_0638
GeneIDi1176264
KEGGiype:YPO3446
ypk:y0740
ypm:YP_0638
PATRICifig|214092.21.peg.3937

Similar proteinsi

Entry informationi

Entry nameiOTC_YERPE
AccessioniPrimary (citable) accession number: Q8ZBG8
Secondary accession number(s): Q0WBK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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