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Q8ZBG8 (OTC_YERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3
Gene names
Name:argI
Ordered Locus Names:YPO3446, y0740, YP_0638
OrganismYersinia pestis [Reference proteome] [HAMAP]
Taxonomic identifier632 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline By similarity. HAMAP-Rule MF_01109

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP-Rule MF_01109

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP-Rule MF_01109

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the ATCase/OTCase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Ornithine carbamoyltransferase HAMAP-Rule MF_01109
PRO_0000113059

Regions

Region56 – 605Carbamoyl phosphate binding By similarity
Region134 – 1374Carbamoyl phosphate binding By similarity
Region236 – 2372Ornithine binding By similarity
Region273 – 2764Carbamoyl phosphate binding By similarity

Sites

Binding site101Carbamoyl phosphate By similarity
Binding site721Carbamoyl phosphate By similarity
Binding site831Carbamoyl phosphate By similarity
Binding site1071Carbamoyl phosphate By similarity
Binding site1681Ornithine By similarity
Binding site2321Ornithine By similarity
Binding site3021Carbamoyl phosphate By similarity
Binding site3201Carbamoyl phosphate By similarity
Site311Important for structural integrity By similarity
Site1471Important for structural integrity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8ZBG8 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 1A135B27870FB2C1

FASTA33537,478
        10         20         30         40         50         60 
MNQFYKRHFL RLLDFTPAEI IALLDLATEL KKDKKSGCEQ QKLVGKNIAL IFEKDSTRTR 

        70         80         90        100        110        120 
CSFEVAAYDQ GARVTYLGPG GSQIGHKESI KDTARVLGRM YDGIQYRGYG QRVVETLAEF 

       130        140        150        160        170        180 
AGVPVWNGLT DEFHPTQLLA DLLTMREHLP NKSLNKMTLA YLGDTRNNMG NSLLEAAALV 

       190        200        210        220        230        240 
GMDLRLVAPK ACWPEEAFVI SCQALAQKTG GKITLTEDIA EGVNGADFLY TDVWVSMGEP 

       250        260        270        280        290        300 
KEVWQERINL LKPYQVNMRV LTLTGNPQVK FLHCLPAFHD DQTTIGKQMA EQYDLPGGME 

       310        320        330 
VTEEVFESAH SIVFDQAENR LHTIKAVMVA TMSKI

« Hide

References

[1]"Genome sequence of Yersinia pestis, the causative agent of plague."
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. expand/collapse author list , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:523-527(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CO-92 / Biovar Orientalis.
[2]"Genome sequence of Yersinia pestis KIM."
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. expand/collapse author list , Matson J.S., Blattner F.R., Perry R.D.
J. Bacteriol. 184:4601-4611(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KIM10+ / Biovar Mediaevalis.
[3]"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. expand/collapse author list , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL590842 Genomic DNA. Translation: CAL22035.1.
AE009952 Genomic DNA. Translation: AAM84327.1.
AE017042 Genomic DNA. Translation: AAS60906.1.
PIRAH0418.
RefSeqNP_668076.1. NC_004088.1.
NP_992029.1. NC_005810.1.
YP_002348337.1. NC_003143.1.

3D structure databases

ProteinModelPortalQ8ZBG8.
SMRQ8ZBG8. Positions 4-334.
ModBaseSearch...

Protein-protein interaction databases

IntActQ8ZBG8. 1 interaction.
STRING214092.YPO3446.

Proteomic databases

PRIDEQ8ZBG8.

Protocols and materials databases

DNASU1145687.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM84327; AAM84327; y0740.
AAS60906; AAS60906; YP_0638.
GeneID1145687.
1176264.
2763679.
KEGGype:YPO3446.
ypk:y0740.
ypm:YP_0638.

Phylogenomic databases

eggNOGCOG0078.
HOGENOMHOG000022686.
KOK00611.
OMARLMDFTP.
ProtClustDBPRK03515.

Enzyme and pathway databases

UniPathwayUPA00068; UER00112.

Family and domain databases

HAMAPMF_01109. OTCase.
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00658. orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTC_YERPE
AccessionPrimary (citable) accession number: Q8ZBG8
Secondary accession number(s): Q0WBK1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2002
Last modified: May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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