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Q8ZBG8

- OTC_YERPE

UniProt

Q8ZBG8 - OTC_YERPE

Protein

Ornithine carbamoyltransferase

Gene

argI

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    • Comment

    Functioni

    Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

    Catalytic activityi

    Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei10 – 101Carbamoyl phosphateUniRule annotation
    Sitei31 – 311Important for structural integrityUniRule annotation
    Binding sitei72 – 721Carbamoyl phosphateUniRule annotation
    Binding sitei83 – 831Carbamoyl phosphateUniRule annotation
    Binding sitei107 – 1071Carbamoyl phosphateUniRule annotation
    Sitei147 – 1471Important for structural integrityUniRule annotation
    Binding sitei168 – 1681OrnithineBy similarity
    Binding sitei232 – 2321OrnithineBy similarity
    Binding sitei302 – 3021Carbamoyl phosphateUniRule annotation
    Binding sitei320 – 3201Carbamoyl phosphateUniRule annotation

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. ornithine carbamoyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-3401-MONOMER.
    UniPathwayiUPA00068; UER00112.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ornithine carbamoyltransferaseUniRule annotation (EC:2.1.3.3UniRule annotation)
    Short name:
    OTCaseUniRule annotation
    Gene namesi
    Name:argIUniRule annotation
    Ordered Locus Names:YPO3446, y0740, YP_0638
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Ornithine carbamoyltransferasePRO_0000113059Add
    BLAST

    Proteomic databases

    PRIDEiQ8ZBG8.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8ZBG8. 1 interaction.
    STRINGi214092.YPO3446.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZBG8.
    SMRiQ8ZBG8. Positions 4-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni56 – 605Carbamoyl phosphate bindingUniRule annotation
    Regioni134 – 1374Carbamoyl phosphate bindingUniRule annotation
    Regioni236 – 2372Ornithine bindingUniRule annotation
    Regioni273 – 2764Carbamoyl phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the ATCase/OTCase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0078.
    HOGENOMiHOG000022686.
    KOiK00611.
    OMAiYQRHFLR.
    OrthoDBiEOG690MGV.

    Family and domain databases

    Gene3Di3.40.50.1370. 2 hits.
    HAMAPiMF_01109. OTCase.
    InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    IPR002292. Orn/put_carbamltrans.
    IPR024904. Orn_carbamltrans.
    [Graphical view]
    PfamiPF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view]
    PRINTSiPR00100. AOTCASE.
    PR00102. OTCASE.
    SUPFAMiSSF53671. SSF53671. 1 hit.
    TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
    PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8ZBG8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQFYKRHFL RLLDFTPAEI IALLDLATEL KKDKKSGCEQ QKLVGKNIAL    50
    IFEKDSTRTR CSFEVAAYDQ GARVTYLGPG GSQIGHKESI KDTARVLGRM 100
    YDGIQYRGYG QRVVETLAEF AGVPVWNGLT DEFHPTQLLA DLLTMREHLP 150
    NKSLNKMTLA YLGDTRNNMG NSLLEAAALV GMDLRLVAPK ACWPEEAFVI 200
    SCQALAQKTG GKITLTEDIA EGVNGADFLY TDVWVSMGEP KEVWQERINL 250
    LKPYQVNMRV LTLTGNPQVK FLHCLPAFHD DQTTIGKQMA EQYDLPGGME 300
    VTEEVFESAH SIVFDQAENR LHTIKAVMVA TMSKI 335
    Length:335
    Mass (Da):37,478
    Last modified:March 1, 2002 - v1
    Checksum:i1A135B27870FB2C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL22035.1.
    AE009952 Genomic DNA. Translation: AAM84327.1.
    AE017042 Genomic DNA. Translation: AAS60906.1.
    PIRiAH0418.
    RefSeqiNP_668076.1. NC_004088.1.
    NP_992029.1. NC_005810.1.
    YP_002348337.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM84327; AAM84327; y0740.
    AAS60906; AAS60906; YP_0638.
    GeneIDi1145687.
    1176264.
    2763679.
    KEGGiype:YPO3446.
    ypk:y0740.
    ypm:YP_0638.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL22035.1 .
    AE009952 Genomic DNA. Translation: AAM84327.1 .
    AE017042 Genomic DNA. Translation: AAS60906.1 .
    PIRi AH0418.
    RefSeqi NP_668076.1. NC_004088.1.
    NP_992029.1. NC_005810.1.
    YP_002348337.1. NC_003143.1.

    3D structure databases

    ProteinModelPortali Q8ZBG8.
    SMRi Q8ZBG8. Positions 4-334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8ZBG8. 1 interaction.
    STRINGi 214092.YPO3446.

    Proteomic databases

    PRIDEi Q8ZBG8.

    Protocols and materials databases

    DNASUi 1145687.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM84327 ; AAM84327 ; y0740 .
    AAS60906 ; AAS60906 ; YP_0638 .
    GeneIDi 1145687.
    1176264.
    2763679.
    KEGGi ype:YPO3446.
    ypk:y0740.
    ypm:YP_0638.

    Phylogenomic databases

    eggNOGi COG0078.
    HOGENOMi HOG000022686.
    KOi K00611.
    OMAi YQRHFLR.
    OrthoDBi EOG690MGV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00112 .
    BioCyci YPES214092:GKDD-3401-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1370. 2 hits.
    HAMAPi MF_01109. OTCase.
    InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    IPR002292. Orn/put_carbamltrans.
    IPR024904. Orn_carbamltrans.
    [Graphical view ]
    Pfami PF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00100. AOTCASE.
    PR00102. OTCASE.
    SUPFAMi SSF53671. SSF53671. 1 hit.
    TIGRFAMsi TIGR00658. orni_carb_tr. 1 hit.
    PROSITEi PS00097. CARBAMOYLTRANSFERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiOTC_YERPE
    AccessioniPrimary (citable) accession number: Q8ZBG8
    Secondary accession number(s): Q0WBK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3