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Protein

Ornithine carbamoyltransferase

Gene

argI

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argI), Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10Carbamoyl phosphateUniRule annotation1
Binding sitei72Carbamoyl phosphateUniRule annotation1
Binding sitei83Carbamoyl phosphateUniRule annotation1
Binding sitei107Carbamoyl phosphateUniRule annotation1
Binding sitei168OrnithineBy similarity1
Binding sitei232OrnithineBy similarity1
Binding sitei302Carbamoyl phosphateUniRule annotation1
Binding sitei320Carbamoyl phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00112.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferaseUniRule annotation (EC:2.1.3.3UniRule annotation)
Short name:
OTCaseUniRule annotation
Gene namesi
Name:argIUniRule annotation
Ordered Locus Names:YPO3446, y0740, YP_0638
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001130591 – 335Ornithine carbamoyltransferaseAdd BLAST335

Proteomic databases

PRIDEiQ8ZBG8.

Interactioni

Protein-protein interaction databases

IntActiQ8ZBG8. 1 interactor.
STRINGi187410.y0740.

Structurei

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei31Important for structural integrityUniRule annotation1
Sitei147Important for structural integrityUniRule annotation1

3D structure databases

ProteinModelPortaliQ8ZBG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 60Carbamoyl phosphate bindingUniRule annotation5
Regioni134 – 137Carbamoyl phosphate bindingUniRule annotation4
Regioni236 – 237Ornithine bindingUniRule annotation2
Regioni273 – 276Carbamoyl phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DBV. Bacteria.
COG0078. LUCA.
HOGENOMiHOG000022686.
KOiK00611.
OMAiSACWPEA.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. OTCase_ArgI.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZBG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQFYKRHFL RLLDFTPAEI IALLDLATEL KKDKKSGCEQ QKLVGKNIAL
60 70 80 90 100
IFEKDSTRTR CSFEVAAYDQ GARVTYLGPG GSQIGHKESI KDTARVLGRM
110 120 130 140 150
YDGIQYRGYG QRVVETLAEF AGVPVWNGLT DEFHPTQLLA DLLTMREHLP
160 170 180 190 200
NKSLNKMTLA YLGDTRNNMG NSLLEAAALV GMDLRLVAPK ACWPEEAFVI
210 220 230 240 250
SCQALAQKTG GKITLTEDIA EGVNGADFLY TDVWVSMGEP KEVWQERINL
260 270 280 290 300
LKPYQVNMRV LTLTGNPQVK FLHCLPAFHD DQTTIGKQMA EQYDLPGGME
310 320 330
VTEEVFESAH SIVFDQAENR LHTIKAVMVA TMSKI
Length:335
Mass (Da):37,478
Last modified:March 1, 2002 - v1
Checksum:i1A135B27870FB2C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL22035.1.
AE009952 Genomic DNA. Translation: AAM84327.1.
AE017042 Genomic DNA. Translation: AAS60906.1.
PIRiAH0418.
RefSeqiWP_002209302.1. NZ_LQBA01000099.1.
YP_002348337.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84327; AAM84327; y0740.
AAS60906; AAS60906; YP_0638.
GeneIDi1176264.
KEGGiype:YPO3446.
ypk:y0740.
ypm:YP_0638.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL22035.1.
AE009952 Genomic DNA. Translation: AAM84327.1.
AE017042 Genomic DNA. Translation: AAS60906.1.
PIRiAH0418.
RefSeqiWP_002209302.1. NZ_LQBA01000099.1.
YP_002348337.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ8ZBG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8ZBG8. 1 interactor.
STRINGi187410.y0740.

Proteomic databases

PRIDEiQ8ZBG8.

Protocols and materials databases

DNASUi1145687.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM84327; AAM84327; y0740.
AAS60906; AAS60906; YP_0638.
GeneIDi1176264.
KEGGiype:YPO3446.
ypk:y0740.
ypm:YP_0638.

Phylogenomic databases

eggNOGiENOG4105DBV. Bacteria.
COG0078. LUCA.
HOGENOMiHOG000022686.
KOiK00611.
OMAiSACWPEA.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00112.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. OTCase_ArgI.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOTC_YERPE
AccessioniPrimary (citable) accession number: Q8ZBG8
Secondary accession number(s): Q0WBK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.