Reviewed, UniProtKB/Swiss-Prot Q8ZB47 (KDSC_YERPE)

Names and origin

Protein names

Recommended name:
    3-deoxy-D-manno-octulosonate 8-phosphate phosphatase
    EC=3.1.3.45
Alternative name(s):
    KDO 8-P phosphatase

Gene names

Name:	kdsC
Ordered Locus Names:	YPO3578, y0150, YP_3833

Organism

Yersinia pestis [Complete proteome] [HAMAP]

Taxonomic identifier

632 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate By similarity.
Catalytic activity	3-deoxy-D-manno-octulosonate 8-phosphate + H2O = 3-deoxy-D-manno-octulosonate + phosphate.
Cofactor	Magnesium Probable.
Pathway	Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 3/3. Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the kdsC family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-deoxy-manno-octulosonate-8-phosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 187	187	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase		PRO_0000201702

Sequences

	Sequence		Length	Mass (Da)
	Q8ZB47-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 299EA75C7DEA7878	FASTA	187	20,299
	10 20 30 40 50 60 MSNTAYIDTC YGPVADDVIQ RAANIRLLIC DVDGVMSDGL IYMGNQGEEL KAFNVRDGYG 70 80 90 100 110 120 IRCLITSDID VAIITGRRAK LLEDRANTLG ITHLYQGQSD KLVAYHELLA TLQCQPEQVA 130 140 150 160 170 180 YIGDDLIDWP VMAQVGLSVA VADAHPLLLP KAHYVTRIKG GRGAVREVCD LILLAQDKLE GATGLSI

References

[1]	"Genome sequence of Yersinia pestis, the causative agent of plague." Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:523-527(2001) [PubMed: 11586360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CO-92 / Biovar Orientalis.
[2]	"Genome sequence of Yersinia pestis KIM." Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. , Matson J.S., Blattner F.R., Perry R.D. J. Bacteriol. 184:4601-4611(2002) [PubMed: 12142430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIM5 / Biovar Mediaevalis.
[3]	"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans." Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R. DNA Res. 11:179-197(2004) [PubMed: 15368893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL590842 Genomic DNA. Translation: CAL22166.1. AE009952 Genomic DNA. Translation: AAM83744.1. AE017042 Genomic DNA. Translation: AAS63980.1.
PIR	AC0435.
RefSeq	NP_667493.1. NP_995103.1. YP_002348465.1.
3D structure databases
HSSP	HSSP built from PDB template 1K1E based on UniProtKB P45314.
ModBase	Search...
Genome annotation databases
GeneID	1145097. 1176398. 2764371.
GenomeReviews	Gene locus y0150 in contig AE009952_GR. Gene locus YP_3833 in contig AE017042_GR. Gene locus YPO3578 in contig AL590842_GR.
KEGG	ype:YPO3578. ypk:y0150. ypm:YP_3833.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8ZB47.
OMA	Q8ZB47. KTFNTLD.
Enzyme and pathway databases
BioCyc	YPES187410:Y0150-MON. YPES214092:YPO3578-MON. YPES229193:YP3833-MON.
BRENDA	3.1.3.45. 142588.
Family and domain databases
InterPro	IPR013200. HAD-SF_hydro-like_3. IPR006549. HAD-SF_hydro_IIIA. IPR010023. Phosphatase_KdsC. [Graphical view]
Pfam	PF08282. Hydrolase_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR01662. HAD-SF-IIIA. 1 hit. TIGR01670. YrbI-phosphatas. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSC_YERPE

Accession

Primary (citable) accession number: Q8ZB47
Secondary accession number(s): Q0WB73

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	March 1, 2002
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)