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Q8ZAS2

- G6PI_YERPE

UniProt

Q8ZAS2 - G6PI_YERPE

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Protein

Glucose-6-phosphate isomerase

Gene
pgi, YPO3718, y0024, YP_3080
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei355 – 3551Proton donor By similarity
Active sitei386 – 3861 By similarity
Active sitei514 – 5141 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3674-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:YPO3718, y0024, YP_3080
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Glucose-6-phosphate isomeraseUniRule annotationPRO_0000180775Add
BLAST

Proteomic databases

PRIDEiQ8ZAS2.

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO3718.

Structurei

3D structure databases

ProteinModelPortaliQ8ZAS2.
SMRiQ8ZAS2. Positions 7-548.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiNCHFVAN.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZAS2-1 [UniParc]FASTAAdd to Basket

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MKNINPSQTA AWKALQQHFE QMKDVTISSL FAKDDQRFNR FSATFDDQML    50
VDFSKNRITS ETLEKLQDLA KETDLAGAIK SMFSGEKINR TEDRAVLHIA 100
LRNRSNTPIV VDGKDVMPEV NAVLAKMKQF CDRVISGDWK GYTGKAITDV 150
VNIGIGGSDL GPYMVTEALR PYKNHLNMHF VSNVDGTHIA EALKPLNPET 200
TLFLVASKTF TTQETMTNAH SARDWFLSAA GDPAHVAKHF AALSTNAKAV 250
GEFGIDTNNM FEFWDWVGGR YSLWSAIGLS IALSVGFEHF EQLLSGAHAM 300
DKHFAETPAE KNLPVLLALI GIWYNNFFGA ETEAILPYDQ YMHRFPAYFQ 350
QGNMESNGKY VDRNGHPVDY QTGPIIWGEP GTNGQHAFYQ LIHQGTKLIP 400
CDFIAPAISH NPLSDHHAKL LSNFFAQTEA LAFGKSLEDV EAEFAAAGKT 450
PEQVAHVAPF KVFEGNRPTN SILLREITPF SLGALIALYE HKIFTQGVIL 500
NIYTFDQWGV ELGKQLANRI LPELADDQEV TSHDSSTNAL INRFKNWR 548
Length:548
Mass (Da):61,161
Last modified:March 27, 2002 - v1
Checksum:i3ED9D49B3A308A3B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti297 – 2971A → S in AAS63251. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL22305.1.
AE009952 Genomic DNA. Translation: AAM83619.1.
AE017042 Genomic DNA. Translation: AAS63251.1.
PIRiAF0452.
RefSeqiNP_667368.1. NC_004088.1.
NP_994374.1. NC_005810.1.
YP_002348599.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM83619; AAM83619; y0024.
AAS63251; AAS63251; YP_3080.
GeneIDi1144971.
1176537.
2763340.
KEGGiype:YPO3718.
ypk:y0024.
ypm:YP_3080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL22305.1 .
AE009952 Genomic DNA. Translation: AAM83619.1 .
AE017042 Genomic DNA. Translation: AAS63251.1 .
PIRi AF0452.
RefSeqi NP_667368.1. NC_004088.1.
NP_994374.1. NC_005810.1.
YP_002348599.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZAS2.
SMRi Q8ZAS2. Positions 7-548.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214092.YPO3718.

Proteomic databases

PRIDEi Q8ZAS2.

Protocols and materials databases

DNASUi 1144971.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM83619 ; AAM83619 ; y0024 .
AAS63251 ; AAS63251 ; YP_3080 .
GeneIDi 1144971.
1176537.
2763340.
KEGGi ype:YPO3718.
ypk:y0024.
ypm:YP_3080.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000261370.
KOi K01810.
OMAi NCHFVAN.
OrthoDBi EOG64R61J.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
BioCyci YPES214092:GKDD-3674-MONOMER.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiG6PI_YERPE
AccessioniPrimary (citable) accession number: Q8ZAS2
Secondary accession number(s): Q0WAT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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