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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathway: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei355 – 3551Proton donorUniRule annotation
Active sitei386 – 3861UniRule annotation
Active sitei514 – 5141UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3674-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:YPO3718, y0024, YP_3080
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815 Componenti: Chromosome UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Glucose-6-phosphate isomerasePRO_0000180775Add
BLAST

Proteomic databases

PRIDEiQ8ZAS2.

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO3718.

Structurei

3D structure databases

ProteinModelPortaliQ8ZAS2.
SMRiQ8ZAS2. Positions 7-548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZAS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNINPSQTA AWKALQQHFE QMKDVTISSL FAKDDQRFNR FSATFDDQML
60 70 80 90 100
VDFSKNRITS ETLEKLQDLA KETDLAGAIK SMFSGEKINR TEDRAVLHIA
110 120 130 140 150
LRNRSNTPIV VDGKDVMPEV NAVLAKMKQF CDRVISGDWK GYTGKAITDV
160 170 180 190 200
VNIGIGGSDL GPYMVTEALR PYKNHLNMHF VSNVDGTHIA EALKPLNPET
210 220 230 240 250
TLFLVASKTF TTQETMTNAH SARDWFLSAA GDPAHVAKHF AALSTNAKAV
260 270 280 290 300
GEFGIDTNNM FEFWDWVGGR YSLWSAIGLS IALSVGFEHF EQLLSGAHAM
310 320 330 340 350
DKHFAETPAE KNLPVLLALI GIWYNNFFGA ETEAILPYDQ YMHRFPAYFQ
360 370 380 390 400
QGNMESNGKY VDRNGHPVDY QTGPIIWGEP GTNGQHAFYQ LIHQGTKLIP
410 420 430 440 450
CDFIAPAISH NPLSDHHAKL LSNFFAQTEA LAFGKSLEDV EAEFAAAGKT
460 470 480 490 500
PEQVAHVAPF KVFEGNRPTN SILLREITPF SLGALIALYE HKIFTQGVIL
510 520 530 540
NIYTFDQWGV ELGKQLANRI LPELADDQEV TSHDSSTNAL INRFKNWR
Length:548
Mass (Da):61,161
Last modified:March 27, 2002 - v1
Checksum:i3ED9D49B3A308A3B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti297 – 2971A → S in AAS63251 (PubMed:15368893).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL22305.1.
AE009952 Genomic DNA. Translation: AAM83619.1.
AE017042 Genomic DNA. Translation: AAS63251.1.
PIRiAF0452.
RefSeqiNP_667368.1. NC_004088.1.
NP_994374.1. NC_005810.1.
WP_002212085.1. NZ_KN150725.1.
YP_002348599.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM83619; AAM83619; y0024.
AAS63251; AAS63251; YP_3080.
GeneIDi1176537.
KEGGiype:YPO3718.
ypk:y0024.
ypm:YP_3080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL22305.1.
AE009952 Genomic DNA. Translation: AAM83619.1.
AE017042 Genomic DNA. Translation: AAS63251.1.
PIRiAF0452.
RefSeqiNP_667368.1. NC_004088.1.
NP_994374.1. NC_005810.1.
WP_002212085.1. NZ_KN150725.1.
YP_002348599.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ8ZAS2.
SMRiQ8ZAS2. Positions 7-548.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214092.YPO3718.

Proteomic databases

PRIDEiQ8ZAS2.

Protocols and materials databases

DNASUi1144971.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM83619; AAM83619; y0024.
AAS63251; AAS63251; YP_3080.
GeneIDi1176537.
KEGGiype:YPO3718.
ypk:y0024.
ypm:YP_3080.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciYPES214092:GKDD-3674-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiG6PI_YERPE
AccessioniPrimary (citable) accession number: Q8ZAS2
Secondary accession number(s): Q0WAT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: June 24, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.