Q8ZAL4 (DLHH_YERPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative carboxymethylenebutenolidase
EC=3.1.1.45

Alternative name(s):
Dienelactone hydrolase
Short name=DLH

Gene names

Ordered Locus Names:

YPO3787, y0443, YP_3262

Organism

Yersinia pestis

Taxonomic identifier

632 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4-carboxymethylenebut-2-en-4-olide + H2O = 4-oxohex-2-enedioate.
Sequence similarities	Belongs to the dienelactone hydrolase family.
Sequence caution	The sequence AAM84032.1 differs from that shown. Reason: Erroneous initiation. The sequence AAS63430.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	carboxymethylenebutenolidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Putative carboxymethylenebutenolidase		PRO_0000161583
Sites
	Active site	137	1	By similarity
	Active site	194	1	By similarity
	Active site	226	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8ZAL4 [UniParc]. Last modified February 21, 2002. Version 1. Checksum: F10398E0A1ABF1AB	FASTA	267	29,671
	10 20 30 40 50 60 MATAHHTDQL HSLQTHGIHC GETTIPSQGD ELPAYIAKPD QHTGPYPVVI VVQEIFGVHE 70 80 90 100 110 120 HIQDICRRLA KQGYLAIAPE LYFRQGDAKD YSNINELVNN LVKKVPDRQV LVDLDHTAHW 130 140 150 160 170 180 ASRHGGDTKK LAITGFCWGG RIAWLYAAHN PQLKAAVAWY GKLVGEKTLF LPKYPVDVAI 190 200 210 220 230 240 DLCAPVLGLY GGKDTSIPAE HIETMRQALR AANADAEIIV YPEAGHAFNA DYRPSYHAES 250 260 AQDGWQRMLD WFTQHGVSAI PIPEETQ

References

[1]	"Genome sequence of Yersinia pestis, the causative agent of plague." Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:523-527(2001) [PubMed: 11586360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CO-92 / Biovar Orientalis.
[2]	"Genome sequence of Yersinia pestis KIM." Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. , Matson J.S., Blattner F.R., Perry R.D. J. Bacteriol. 184:4601-4611(2002) [PubMed: 12142430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIM5 / Biovar Mediaevalis.
[3]	"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans." Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R. DNA Res. 11:179-197(2004) [PubMed: 15368893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 91001 / Biovar Mediaevalis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL590842 Genomic DNA. Translation: CAL22373.1. AE009952 Genomic DNA. Translation: AAM84032.1. Different initiation. AE017042 Genomic DNA. Translation: AAS63430.1. Different initiation.
PIR	AB0461.
RefSeq	NP_667781.1. NC_004088.1. NP_994553.1. NC_005810.1. YP_002348664.1. NC_003143.1.
3D structure databases
ProteinModelPortal	Q8ZAL4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1145390. 1176621. 2763578.
GenomeReviews	Gene locus y0443 in contig AE009952_GR. Gene locus YP_3262 in contig AE017042_GR. Gene locus YPO3787 in contig AL590842_GR.
KEGG	ype:YPO3787. ypk:y0443. ypm:YP_3262.
Phylogenomic databases
HOGENOM	HBG673102.
OMA	VHEHIAD.
ProtClustDB	CLSK880795.
Enzyme and pathway databases
BioCyc	YPES187410:Y0443-MONOMER. YPES214092:YPO3787-MONOMER.
Family and domain databases
InterPro	IPR002925. Dienelactn_hydro. [Graphical view]
KO	K01061.
Pfam	PF01738. DLH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DLHH_YERPE

Accession

Primary (citable) accession number: Q8ZAL4
Secondary accession number(s): Q0WAM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2002
Last sequence update:	February 21, 2002
Last modified:	November 16, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program