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Q8ZAL3

- METE_YERPE

UniProt

Q8ZAL3 - METE_YERPE

Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene

metE

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.UniRule annotation

    Catalytic activityi

    5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi644 – 6441ZincUniRule annotation
    Metal bindingi646 – 6461ZincUniRule annotation
    Metal bindingi729 – 7291ZincUniRule annotation

    GO - Molecular functioni

    1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. methionine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Methionine biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-3758-MONOMER.
    UniPathwayiUPA00051; UER00082.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotation (EC:2.1.1.14UniRule annotation)
    Alternative name(s):
    Cobalamin-independent methionine synthaseUniRule annotation
    Methionine synthase, vitamin-B12 independent isozymeUniRule annotation
    Gene namesi
    Name:metEUniRule annotation
    Ordered Locus Names:YPO3788, y0442, YP_3261
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7587585-methyltetrahydropteroyltriglutamate--homocysteine methyltransferasePRO_0000098682Add
    BLAST

    Proteomic databases

    PRIDEiQ8ZAL3.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8ZAL3. 4 interactions.
    STRINGi214092.YPO3788.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZAL3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the vitamin-B12 independent methionine synthase family.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0620.
    HOGENOMiHOG000246221.
    KOiK00549.
    OMAiEYFGELM.
    OrthoDBiEOG6FFS3G.

    Family and domain databases

    HAMAPiMF_00172. Meth_synth.
    InterProiIPR013215. Cbl-indep_Met_Synth_N.
    IPR006276. Cobalamin-indep_Met_synthase.
    IPR002629. Met_Synth_C/arc.
    [Graphical view]
    PfamiPF08267. Meth_synt_1. 1 hit.
    PF01717. Meth_synt_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000382. MeTrfase_B12_ind. 1 hit.
    TIGRFAMsiTIGR01371. met_syn_B12ind. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8ZAL3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTILNHTLGF PRVGLKRELK KAQESYWAGN STQEELLNVG RELRARHWQQ    50
    QQQAGVDLVP VGDFAWYDHV LTTSLLLGNV PERHQNADGS IDIDTLFRIG 100
    RGRAPTGKPA AAAEMTKWFN TNYHYMVPEF QQGQQFKLGW TQLLDEVDEA 150
    LALGHKIKPV LLGPITYLWL GKVKGEQFDR LSLLNDILPV YQQVLAELAK 200
    RGIEWVQIDE PALVLELPQE WLDAYQPAYQ ALQGQVKLLL TTYFDSIGHN 250
    IDTIRALPVQ GLHVDVVTGH DDLAVLNKNL PKEWLLSLGV INGRNVWRAD 300
    LSSWFERLQP LVNSRPLWLG SSCSLLHSPI DLNEETRLDA EVKSWFAFAL 350
    QKCAELALLT QALNAPNDAK LAELAAYSAP IRARRSSSRV HNAQVEQRLA 400
    AITSQDIERQ LPYEARAETQ RKRFNLPAWP TTTIGSFPQT TEIRGLRLDF 450
    KQGRLDGKNY RTGISEHIKH AIAEQERLGL DVLVHGEAER NDMVEYFGEH 500
    LDGFVFTQNG WVQSYGSRCV KPPVIIGDIS RPEAITVEWA KYAQSLTEKP 550
    VKGMLTGPVT ILCWSFPRED VSRETIAKQI ALALRDEVED LEKAGIGIIQ 600
    IDEPALREGL PLRRADWQAY LQWAVDAFKL NAAVAQNDTQ IHTHMCYCEF 650
    NDIMDSIAAL DADVITIETS RSDMELLESF EDFAYPNEIG PGVYDIHSPN 700
    VPSVEWIEAL LRKAAQRIPA ERLWVNPDCG LKTRGWPETR QALANMVLAA 750
    QRLREEQV 758
    Length:758
    Mass (Da):85,677
    Last modified:March 1, 2002 - v1
    Checksum:i48F4B4D74BB63C3C
    GO

    Sequence cautioni

    The sequence AAM84031.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL22374.1.
    AE009952 Genomic DNA. Translation: AAM84031.1. Different initiation.
    AE017042 Genomic DNA. Translation: AAS63429.1.
    PIRiAC0461.
    RefSeqiNP_667780.1. NC_004088.1.
    NP_994552.1. NC_005810.1.
    YP_002348665.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM84031; AAM84031; y0442.
    AAS63429; AAS63429; YP_3261.
    GeneIDi1145389.
    1176622.
    2763568.
    KEGGiype:YPO3788.
    ypk:y0442.
    ypm:YP_3261.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL22374.1 .
    AE009952 Genomic DNA. Translation: AAM84031.1 . Different initiation.
    AE017042 Genomic DNA. Translation: AAS63429.1 .
    PIRi AC0461.
    RefSeqi NP_667780.1. NC_004088.1.
    NP_994552.1. NC_005810.1.
    YP_002348665.1. NC_003143.1.

    3D structure databases

    ProteinModelPortali Q8ZAL3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8ZAL3. 4 interactions.
    STRINGi 214092.YPO3788.

    Proteomic databases

    PRIDEi Q8ZAL3.

    Protocols and materials databases

    DNASUi 1145389.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM84031 ; AAM84031 ; y0442 .
    AAS63429 ; AAS63429 ; YP_3261 .
    GeneIDi 1145389.
    1176622.
    2763568.
    KEGGi ype:YPO3788.
    ypk:y0442.
    ypm:YP_3261.

    Phylogenomic databases

    eggNOGi COG0620.
    HOGENOMi HOG000246221.
    KOi K00549.
    OMAi EYFGELM.
    OrthoDBi EOG6FFS3G.

    Enzyme and pathway databases

    UniPathwayi UPA00051 ; UER00082 .
    BioCyci YPES214092:GKDD-3758-MONOMER.

    Family and domain databases

    HAMAPi MF_00172. Meth_synth.
    InterProi IPR013215. Cbl-indep_Met_Synth_N.
    IPR006276. Cobalamin-indep_Met_synthase.
    IPR002629. Met_Synth_C/arc.
    [Graphical view ]
    Pfami PF08267. Meth_synt_1. 1 hit.
    PF01717. Meth_synt_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000382. MeTrfase_B12_ind. 1 hit.
    TIGRFAMsi TIGR01371. met_syn_B12ind. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiMETE_YERPE
    AccessioniPrimary (citable) accession number: Q8ZAL3
    Secondary accession number(s): Q0WAM3, Q8D1I5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3