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Q8ZAL3

- METE_YERPE

UniProt

Q8ZAL3 - METE_YERPE

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Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene
metE, YPO3788, y0442, YP_3261
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity.UniRule annotation

Catalytic activityi

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi644 – 6441Zinc By similarity
Metal bindingi646 – 6461Zinc By similarity
Metal bindingi729 – 7291Zinc By similarity

GO - Molecular functioni

  1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. methionine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3758-MONOMER.
UniPathwayiUPA00051; UER00082.

Names & Taxonomyi

Protein namesi
Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC:2.1.1.14)
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene namesi
Name:metE
Ordered Locus Names:YPO3788, y0442, YP_3261
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7587585-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotationPRO_0000098682Add
BLAST

Proteomic databases

PRIDEiQ8ZAL3.

Interactioni

Protein-protein interaction databases

IntActiQ8ZAL3. 4 interactions.
STRINGi214092.YPO3788.

Structurei

3D structure databases

ProteinModelPortaliQ8ZAL3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0620.
HOGENOMiHOG000246221.
KOiK00549.
OMAiEYFGELM.
OrthoDBiEOG6FFS3G.

Family and domain databases

HAMAPiMF_00172. Meth_synth.
InterProiIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view]
PfamiPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsiTIGR01371. met_syn_B12ind. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZAL3-1 [UniParc]FASTAAdd to Basket

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MTILNHTLGF PRVGLKRELK KAQESYWAGN STQEELLNVG RELRARHWQQ    50
QQQAGVDLVP VGDFAWYDHV LTTSLLLGNV PERHQNADGS IDIDTLFRIG 100
RGRAPTGKPA AAAEMTKWFN TNYHYMVPEF QQGQQFKLGW TQLLDEVDEA 150
LALGHKIKPV LLGPITYLWL GKVKGEQFDR LSLLNDILPV YQQVLAELAK 200
RGIEWVQIDE PALVLELPQE WLDAYQPAYQ ALQGQVKLLL TTYFDSIGHN 250
IDTIRALPVQ GLHVDVVTGH DDLAVLNKNL PKEWLLSLGV INGRNVWRAD 300
LSSWFERLQP LVNSRPLWLG SSCSLLHSPI DLNEETRLDA EVKSWFAFAL 350
QKCAELALLT QALNAPNDAK LAELAAYSAP IRARRSSSRV HNAQVEQRLA 400
AITSQDIERQ LPYEARAETQ RKRFNLPAWP TTTIGSFPQT TEIRGLRLDF 450
KQGRLDGKNY RTGISEHIKH AIAEQERLGL DVLVHGEAER NDMVEYFGEH 500
LDGFVFTQNG WVQSYGSRCV KPPVIIGDIS RPEAITVEWA KYAQSLTEKP 550
VKGMLTGPVT ILCWSFPRED VSRETIAKQI ALALRDEVED LEKAGIGIIQ 600
IDEPALREGL PLRRADWQAY LQWAVDAFKL NAAVAQNDTQ IHTHMCYCEF 650
NDIMDSIAAL DADVITIETS RSDMELLESF EDFAYPNEIG PGVYDIHSPN 700
VPSVEWIEAL LRKAAQRIPA ERLWVNPDCG LKTRGWPETR QALANMVLAA 750
QRLREEQV 758
Length:758
Mass (Da):85,677
Last modified:March 1, 2002 - v1
Checksum:i48F4B4D74BB63C3C
GO

Sequence cautioni

The sequence AAM84031.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL22374.1.
AE009952 Genomic DNA. Translation: AAM84031.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS63429.1.
PIRiAC0461.
RefSeqiNP_667780.1. NC_004088.1.
NP_994552.1. NC_005810.1.
YP_002348665.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84031; AAM84031; y0442.
AAS63429; AAS63429; YP_3261.
GeneIDi1145389.
1176622.
2763568.
KEGGiype:YPO3788.
ypk:y0442.
ypm:YP_3261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL22374.1 .
AE009952 Genomic DNA. Translation: AAM84031.1 . Different initiation.
AE017042 Genomic DNA. Translation: AAS63429.1 .
PIRi AC0461.
RefSeqi NP_667780.1. NC_004088.1.
NP_994552.1. NC_005810.1.
YP_002348665.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q8ZAL3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8ZAL3. 4 interactions.
STRINGi 214092.YPO3788.

Proteomic databases

PRIDEi Q8ZAL3.

Protocols and materials databases

DNASUi 1145389.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM84031 ; AAM84031 ; y0442 .
AAS63429 ; AAS63429 ; YP_3261 .
GeneIDi 1145389.
1176622.
2763568.
KEGGi ype:YPO3788.
ypk:y0442.
ypm:YP_3261.

Phylogenomic databases

eggNOGi COG0620.
HOGENOMi HOG000246221.
KOi K00549.
OMAi EYFGELM.
OrthoDBi EOG6FFS3G.

Enzyme and pathway databases

UniPathwayi UPA00051 ; UER00082 .
BioCyci YPES214092:GKDD-3758-MONOMER.

Family and domain databases

HAMAPi MF_00172. Meth_synth.
InterProi IPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view ]
Pfami PF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsi TIGR01371. met_syn_B12ind. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiMETE_YERPE
AccessioniPrimary (citable) accession number: Q8ZAL3
Secondary accession number(s): Q0WAM3, Q8D1I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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