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Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene

metE

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.UniRule annotation

Catalytic activityi

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from L-homocysteine (MetE route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from L-homocysteine (MetE route), the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi644ZincUniRule annotation1
Metal bindingi646ZincUniRule annotation1
Metal bindingi729ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00051; UER00082

Names & Taxonomyi

Protein namesi
Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotation (EC:2.1.1.14UniRule annotation)
Alternative name(s):
Cobalamin-independent methionine synthaseUniRule annotation
Methionine synthase, vitamin-B12 independent isozymeUniRule annotation
Gene namesi
Name:metEUniRule annotation
Ordered Locus Names:YPO3788, y0442, YP_3261
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000986821 – 7585-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseAdd BLAST758

Proteomic databases

PaxDbiQ8ZAL3

Interactioni

Protein-protein interaction databases

IntActiQ8ZAL3, 4 interactors
STRINGi187410.y0442

Structurei

3D structure databases

ProteinModelPortaliQ8ZAL3
SMRiQ8ZAL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vitamin-B12 independent methionine synthase family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DSS Bacteria
COG0620 LUCA
HOGENOMiHOG000246221
KOiK00549
OMAiGRNIWKN

Family and domain databases

Gene3Di3.20.20.210, 4 hits
HAMAPiMF_00172 Meth_synth, 1 hit
InterProiView protein in InterPro
IPR013215 Cbl-indep_Met_Synth_N
IPR006276 Cobalamin-indep_Met_synthase
IPR002629 Met_Synth_C/arc
IPR038071 UROD/MetE-like_sf
PfamiView protein in Pfam
PF08267 Meth_synt_1, 1 hit
PF01717 Meth_synt_2, 1 hit
PIRSFiPIRSF000382 MeTrfase_B12_ind, 1 hit
SUPFAMiSSF51726 SSF51726, 2 hits
TIGRFAMsiTIGR01371 met_syn_B12ind, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZAL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTILNHTLGF PRVGLKRELK KAQESYWAGN STQEELLNVG RELRARHWQQ
60 70 80 90 100
QQQAGVDLVP VGDFAWYDHV LTTSLLLGNV PERHQNADGS IDIDTLFRIG
110 120 130 140 150
RGRAPTGKPA AAAEMTKWFN TNYHYMVPEF QQGQQFKLGW TQLLDEVDEA
160 170 180 190 200
LALGHKIKPV LLGPITYLWL GKVKGEQFDR LSLLNDILPV YQQVLAELAK
210 220 230 240 250
RGIEWVQIDE PALVLELPQE WLDAYQPAYQ ALQGQVKLLL TTYFDSIGHN
260 270 280 290 300
IDTIRALPVQ GLHVDVVTGH DDLAVLNKNL PKEWLLSLGV INGRNVWRAD
310 320 330 340 350
LSSWFERLQP LVNSRPLWLG SSCSLLHSPI DLNEETRLDA EVKSWFAFAL
360 370 380 390 400
QKCAELALLT QALNAPNDAK LAELAAYSAP IRARRSSSRV HNAQVEQRLA
410 420 430 440 450
AITSQDIERQ LPYEARAETQ RKRFNLPAWP TTTIGSFPQT TEIRGLRLDF
460 470 480 490 500
KQGRLDGKNY RTGISEHIKH AIAEQERLGL DVLVHGEAER NDMVEYFGEH
510 520 530 540 550
LDGFVFTQNG WVQSYGSRCV KPPVIIGDIS RPEAITVEWA KYAQSLTEKP
560 570 580 590 600
VKGMLTGPVT ILCWSFPRED VSRETIAKQI ALALRDEVED LEKAGIGIIQ
610 620 630 640 650
IDEPALREGL PLRRADWQAY LQWAVDAFKL NAAVAQNDTQ IHTHMCYCEF
660 670 680 690 700
NDIMDSIAAL DADVITIETS RSDMELLESF EDFAYPNEIG PGVYDIHSPN
710 720 730 740 750
VPSVEWIEAL LRKAAQRIPA ERLWVNPDCG LKTRGWPETR QALANMVLAA

QRLREEQV
Length:758
Mass (Da):85,677
Last modified:March 1, 2002 - v1
Checksum:i48F4B4D74BB63C3C
GO

Sequence cautioni

The sequence AAM84031 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL22374.1
AE009952 Genomic DNA Translation: AAM84031.1 Different initiation.
AE017042 Genomic DNA Translation: AAS63429.1
PIRiAC0461
RefSeqiWP_002211526.1, NZ_PDBR01000047.1
YP_002348665.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM84031; AAM84031; y0442
AAS63429; AAS63429; YP_3261
GeneIDi1176622
KEGGiype:YPO3788
ypj:CH55_3228
ypk:y0442
ypl:CH46_1278
ypm:YP_3261
ypv:BZ15_3928
ypw:CH59_1723
PATRICifig|214092.21.peg.4310

Similar proteinsi

Entry informationi

Entry nameiMETE_YERPE
AccessioniPrimary (citable) accession number: Q8ZAL3
Secondary accession number(s): Q0WAM3, Q8D1I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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