Q8ZAH6 (GLPB_YERPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anaerobic glycerol-3-phosphate dehydrogenase subunit B
Short name=Anaerobic G-3-P dehydrogenase subunit B
Short name=Anaerobic G3Pdhase B
EC=1.1.5.3

Gene names

Name:	glpB
Ordered Locus Names:	YPO3825, y0405, YP_3223

Organism

Yersinia pestis [Reference proteome] [HAMAP]

Taxonomic identifier

632 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor By similarity. HAMAP-Rule MF_00753
Catalytic activity	sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. HAMAP-Rule MF_00753
Cofactor	FMN By similarity.
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1. HAMAP-Rule MF_00753
Subunit structure	Composed of a catalytic GlpA/B dimer and of membrane bound GlpC By similarity.
Sequence similarities	Belongs to the anaerobic G-3-P dehydrogenase subunit B family.
Sequence caution	The sequence AAM83994.1 differs from that shown. Reason: Erroneous initiation. The sequence AAS63391.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	FMN Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycerol catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 424	424	Anaerobic glycerol-3-phosphate dehydrogenase subunit B HAMAP-Rule MF_00753		PRO_0000204571

Sequences

	Sequence		Length	Mass (Da)
	Q8ZAH6 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: CEC65C3081A809E7	FASTA	424	45,506
	10 20 30 40 50 60 MKFDVIIIGG GLAGLACGIR LAEQGKYCAI VSSGQNALHF SSGSLDLLAK LPDGQAVSQP 70 80 90 100 110 120 LSALSALAEL APEHPYSKMR NITQLDELVQ EAEALLRRCG LDIVGSSAEN HLRLTPLGSC 130 140 150 160 170 180 RPTWLSLADI PVAPLNGPLP WQRVAVIGIE GFLDFQPQMV ASALQDQGID ATADYLHLPA 190 200 210 220 230 240 LDRLRDNPSE FRAVNIARIL DLPENRQPLA DELSRLSSTA EMILLPACIG LDKSAPLDAL 250 260 270 280 290 300 RAVVGKPIQL LPTLPPSLLG MRLHQALRHR FQQLGGLVMP GDAVLRAELV DNRITGLYSR 310 320 330 340 350 360 NHGDIPLRAA QMVLASGSFF SNGLVATFDK IYEPILDLDI LSLPHRADWS HSNLFAPQPY 370 380 390 400 410 420 LQFGVNTDNH LRPLRGGVAL ENLHAIGAVL GGYDPLQQGC GAGVSLTSAV FVAEQIISEM AVTL

References

[1]	"Genome sequence of Yersinia pestis, the causative agent of plague." Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:523-527(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CO-92 / Biovar Orientalis.
[2]	"Genome sequence of Yersinia pestis KIM." Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. , Matson J.S., Blattner F.R., Perry R.D. J. Bacteriol. 184:4601-4611(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIM10+ / Biovar Mediaevalis.
[3]	"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans." Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R. DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL590842 Genomic DNA. Translation: CAL22412.1. AE009952 Genomic DNA. Translation: AAM83994.1. Different initiation. AE017042 Genomic DNA. Translation: AAS63391.1. Different initiation.
PIR	AI0465.
RefSeq	NP_667743.1. NC_004088.1. NP_994514.1. NC_005810.1. YP_002348703.1. NC_003143.1.
3D structure databases
ProteinModelPortal	Q8ZAH6.
ModBase	Search...
Protein-protein interaction databases
STRING	214092.YPO3825.
Protocols and materials databases
DNASU	1145352.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM83994; AAM83994; y0405. AAS63391; AAS63391; YP_3223.
GeneID	1145352. 1176660. 2764437.
KEGG	ype:YPO3825. ypk:y0405. ypm:YP_3223.
Phylogenomic databases
eggNOG	COG3075.
HOGENOM	HOG000278489.
KO	K00112.
OMA	FRSVNIS.
ProtClustDB	PRK05329.
Enzyme and pathway databases
UniPathway	UPA00618; UER00673.
Family and domain databases
HAMAP	MF_00753. Glycerol3P_GlpB.
InterPro	IPR003953. FAD_bind_dom. IPR009158. G3P_DH_GlpB_su. [Graphical view]
Pfam	PF00890. FAD_binding_2. 1 hit. [Graphical view]
PIRSF	PIRSF000141. Anaerobic_G3P_dh. 1 hit.
TIGRFAMs	TIGR03378. glycerol3P_GlpB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLPB_YERPE

Accession

Primary (citable) accession number: Q8ZAH6
Secondary accession number(s): Q0WAI5, Q8CWI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program