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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei137UniRule annotation1
Active sitei545UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processCarbon dioxide fixation
LigandMagnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:YPO3929, y0308, YP_3121
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001666541 – 878Phosphoenolpyruvate carboxylaseAdd BLAST878

Proteomic databases

PaxDbiQ8ZA84

Interactioni

Protein-protein interaction databases

IntActiQ8ZA84 5 interactors.
STRINGi187410.y0308

Structurei

3D structure databases

ProteinModelPortaliQ8ZA84
SMRiQ8ZA84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCA Bacteria
COG2352 LUCA
HOGENOMiHOG000238648
KOiK01595
OMAiPWVFGWT

Family and domain databases

HAMAPiMF_00595 PEPcase_type1, 1 hit
InterProiView protein in InterPro
IPR021135 PEP_COase
IPR022805 PEP_COase_bac/pln-type
IPR018129 PEP_COase_Lys_AS
IPR033129 PEPCASE_His_AS
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
PANTHERiPTHR30523 PTHR30523, 1 hit
PfamiView protein in Pfam
PF00311 PEPcase, 1 hit
PRINTSiPR00150 PEPCARBXLASE
SUPFAMiSSF51621 SSF51621, 1 hit
PROSITEiView protein in PROSITE
PS00781 PEPCASE_1, 1 hit
PS00393 PEPCASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZA84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEQYSAMRS NVSMLGTLLG DTIKEALGEH ILDRVETIRK LSKSSRAGNE
60 70 80 90 100
ASRQELLTTL QNLSNDELLP VARAFSQFLN LTNTAEQYHS ISPHGEAASN
110 120 130 140 150
PEALAQLFTR LKDKKLSDQD MRSAVDDLSI ELVLTAHPTE ITRRTLIHKL
160 170 180 190 200
VEVNTCLSQL DHNDLADYER NKIMRRLRQL VAQSWHTDEI RKLRPSPVDE
210 220 230 240 250
AKWGFAVVEN SLWEGVPAFL REFNEQLENS LDYRLPVEAV PIRFTSWMGG
260 270 280 290 300
DRDGNPNVTA EITRHVLLLS RWKATDLFLR DIQVLVSELS MSECTPELRE
310 320 330 340 350
LAGGEEVLEP YRQLMKNVRT QLTNTQAYLE ARLKGERVLP PHDLLVSNDQ
360 370 380 390 400
LWEPLYACYQ SLKACGMEII ANGQLLDTLR RVRCFGVPLV RIDVRQESTR
410 420 430 440 450
HTDAIAELTR YLGLGDYESW SESDKQAFLV RELNSKRPLV PLKWEPSAET
460 470 480 490 500
QEVLETCRVI AEAPQGSIAA YVISMAKVPS DVLAVHLLLK EAGCPFTLPV
510 520 530 540 550
APLFETLDDL NNADDVMTQL LGIDWYRGLI QGKQMVMIGY SDSAKDAGVM
560 570 580 590 600
AASWAQYRAQ DALIKTCEKA GITLTLFHGR GGSIGRGGAP AHAALLSQPP
610 620 630 640 650
GSLKGGLRVT EQGEMIRFKF GLPEVTISSL ALYAGAILEA NLLPPPEPKK
660 670 680 690 700
EWIEVMDLLS DASCDMYRSY VRENPEFVRY FRAATPELEL GKLPLGSRPA
710 720 730 740 750
KRRPDGGVES LRAIPWIFAW TQNRLMLPAW LGAGAGLQRA IDAGKQDVLA
760 770 780 790 800
TMCRDWPFFS TRIGMLEMVF AKADLWLAEY YDQRLVDKSL WPLGQQLRDQ
810 820 830 840 850
LAADIKVVLA IANDDHLMAD LPWIAESIAL RNVYTDPLNV LQAELLHRSR
860 870
QQEHPDACVE QALMVTIAGV AAGMRNTG
Length:878
Mass (Da):98,324
Last modified:March 1, 2002 - v1
Checksum:iF57CE8ABD26287B4
GO

Sequence cautioni

The sequence AAM83899 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAS63291 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti669S → N in AAS63291 (PubMed:15368893).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL22512.1
AE009952 Genomic DNA Translation: AAM83899.1 Different initiation.
AE017042 Genomic DNA Translation: AAS63291.1 Different initiation.
PIRiAE0478
RefSeqiWP_002209491.1, NZ_PDBR01000064.1
YP_002348802.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM83899; AAM83899; y0308
AAS63291; AAS63291; YP_3121
GeneIDi1176770
KEGGiype:YPO3929
ypk:y0308
ypm:YP_3121
PATRICifig|214092.21.peg.4457

Similar proteinsi

Entry informationi

Entry nameiCAPP_YERPE
AccessioniPrimary (citable) accession number: Q8ZA84
Secondary accession number(s): Q0WA86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome