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Q8ZA84 (CAPP_YERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoenolpyruvate carboxylase

Short name=PEPC
Short name=PEPCase
EC=4.1.1.31
Gene names
Name:ppc
Ordered Locus Names:YPO3929, y0308, YP_3121
OrganismYersinia pestis [Reference proteome] [HAMAP]
Taxonomic identifier632 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length878 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity. HAMAP-Rule MF_00595

Catalytic activity

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-. HAMAP-Rule MF_00595

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00595

Sequence similarities

Belongs to the PEPCase type 1 family.

Sequence caution

The sequence AAM83899.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAS63291.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCarbon dioxide fixation
   LigandMagnesium
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbon fixation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

oxaloacetate metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tricarboxylic acid cycle

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

phosphoenolpyruvate carboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 878878Phosphoenolpyruvate carboxylase HAMAP-Rule MF_00595
PRO_0000166654

Sites

Active site1371 By similarity
Active site5451 By similarity

Experimental info

Sequence conflict6691S → N in AAS63291. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8ZA84 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: F57CE8ABD26287B4

FASTA87898,324
        10         20         30         40         50         60 
MNEQYSAMRS NVSMLGTLLG DTIKEALGEH ILDRVETIRK LSKSSRAGNE ASRQELLTTL 

        70         80         90        100        110        120 
QNLSNDELLP VARAFSQFLN LTNTAEQYHS ISPHGEAASN PEALAQLFTR LKDKKLSDQD 

       130        140        150        160        170        180 
MRSAVDDLSI ELVLTAHPTE ITRRTLIHKL VEVNTCLSQL DHNDLADYER NKIMRRLRQL 

       190        200        210        220        230        240 
VAQSWHTDEI RKLRPSPVDE AKWGFAVVEN SLWEGVPAFL REFNEQLENS LDYRLPVEAV 

       250        260        270        280        290        300 
PIRFTSWMGG DRDGNPNVTA EITRHVLLLS RWKATDLFLR DIQVLVSELS MSECTPELRE 

       310        320        330        340        350        360 
LAGGEEVLEP YRQLMKNVRT QLTNTQAYLE ARLKGERVLP PHDLLVSNDQ LWEPLYACYQ 

       370        380        390        400        410        420 
SLKACGMEII ANGQLLDTLR RVRCFGVPLV RIDVRQESTR HTDAIAELTR YLGLGDYESW 

       430        440        450        460        470        480 
SESDKQAFLV RELNSKRPLV PLKWEPSAET QEVLETCRVI AEAPQGSIAA YVISMAKVPS 

       490        500        510        520        530        540 
DVLAVHLLLK EAGCPFTLPV APLFETLDDL NNADDVMTQL LGIDWYRGLI QGKQMVMIGY 

       550        560        570        580        590        600 
SDSAKDAGVM AASWAQYRAQ DALIKTCEKA GITLTLFHGR GGSIGRGGAP AHAALLSQPP 

       610        620        630        640        650        660 
GSLKGGLRVT EQGEMIRFKF GLPEVTISSL ALYAGAILEA NLLPPPEPKK EWIEVMDLLS 

       670        680        690        700        710        720 
DASCDMYRSY VRENPEFVRY FRAATPELEL GKLPLGSRPA KRRPDGGVES LRAIPWIFAW 

       730        740        750        760        770        780 
TQNRLMLPAW LGAGAGLQRA IDAGKQDVLA TMCRDWPFFS TRIGMLEMVF AKADLWLAEY 

       790        800        810        820        830        840 
YDQRLVDKSL WPLGQQLRDQ LAADIKVVLA IANDDHLMAD LPWIAESIAL RNVYTDPLNV 

       850        860        870 
LQAELLHRSR QQEHPDACVE QALMVTIAGV AAGMRNTG 

« Hide

References

[1]"Genome sequence of Yersinia pestis, the causative agent of plague."
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. expand/collapse author list , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:523-527(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CO-92 / Biovar Orientalis.
[2]"Genome sequence of Yersinia pestis KIM."
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. expand/collapse author list , Matson J.S., Blattner F.R., Perry R.D.
J. Bacteriol. 184:4601-4611(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KIM10+ / Biovar Mediaevalis.
[3]"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. expand/collapse author list , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590842 Genomic DNA. Translation: CAL22512.1.
AE009952 Genomic DNA. Translation: AAM83899.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS63291.1. Different initiation.
PIRAE0478.
RefSeqYP_002348802.1. NC_003143.1.

3D structure databases

ProteinModelPortalQ8ZA84.
SMRQ8ZA84. Positions 4-878.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8ZA84. 6 interactions.
STRING214092.YPO3929.

Proteomic databases

PRIDEQ8ZA84.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM83899; AAM83899; y0308.
AAS63291; AAS63291; YP_3121.
GeneID1176770.
KEGGype:YPO3929.
PATRIC18598095. VBIYerPes7843_4705.

Phylogenomic databases

eggNOGCOG2352.
HOGENOMHOG000238648.
KOK01595.
OMAISCQHYR.
OrthoDBEOG6TJ7T8.

Enzyme and pathway databases

BioCycYPES214092:GKDD-3906-MONOMER.

Family and domain databases

HAMAPMF_00595. PEPcase_type1.
InterProIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSPR00150. PEPCARBXLASE.
SUPFAMSSF51621. SSF51621. 1 hit.
PROSITEPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAPP_YERPE
AccessionPrimary (citable) accession number: Q8ZA84
Secondary accession number(s): Q0WA86
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families