Q8ZA34 (CDH_YERPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CDP-diacylglycerol pyrophosphatase
EC=3.6.1.26

Alternative name(s):
CDP-diacylglycerol phosphatidylhydrolase
CDP-diglyceride hydrolase

Gene names

Name:	cdh
Ordered Locus Names:	YPO3986, y3843, YP_3349

Organism

Yersinia pestis

Taxonomic identifier

632 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	CDP-diacylglycerol + H2O = CMP + phosphatidate. HAMAP MF_00319
Pathway	Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1. HAMAP MF_00319
Subcellular location	Cell inner membrane; Single-pass membrane protein By similarity HAMAP MF_00319.
Sequence similarities	Belongs to the cdh family.
Sequence caution	The sequence AAM87388.1 differs from that shown. Reason: Erroneous initiation. The sequence AAS63514.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	CDP-diacylglycerol pyrophosphatase HAMAP MF_00319		PRO_0000198584
Regions
	Transmembrane	10 – 30	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8ZA34 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 270AB6432698A446	FASTA	258	28,779
	10 20 30 40 50 60 MSRSIKWRRY LLTLLILIIL AAGLIYKLRF SNADALWKII SQQCIPHMTT EDDPRPCAEV 70 80 90 100 110 120 NIPAGFAVLK DRNGPLQYLL IPTVPISGIE SPQLLTATSP NYFADAWQAR YFMAEKYGAP 130 140 150 160 170 180 IDDTDISLAI NSQYGRTQDQ LHIHISCLKP QVKTALAAHS ADFQQQWQPL PGGLLGHDYW 190 200 210 220 230 240 VRRITATELQ QPGPFHLLAD EMPGAKEQMG RYGLAITALP SGDFLLLANK ASLITQDRAS 250 AEELQDHTCQ VLPHLPVQ

References

[1]	"Genome sequence of Yersinia pestis, the causative agent of plague." Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:523-527(2001) [PubMed: 11586360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CO-92 / Biovar Orientalis.
[2]	"Genome sequence of Yersinia pestis KIM." Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. , Matson J.S., Blattner F.R., Perry R.D. J. Bacteriol. 184:4601-4611(2002) [PubMed: 12142430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIM5 / Biovar Mediaevalis.
[3]	"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans." Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R. DNA Res. 11:179-197(2004) [PubMed: 15368893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL590842 Genomic DNA. Translation: CAL22566.1. AE009952 Genomic DNA. Translation: AAM87388.1. Different initiation. AE017042 Genomic DNA. Translation: AAS63514.1. Different initiation.
PIR	AC0485.
RefSeq	NP_671137.1. NC_004088.1. NP_994637.1. NC_005810.1. YP_002348856.1. NC_003143.1.
3D structure databases
ProteinModelPortal	Q8ZA34.
SMR	Q8ZA34. Positions 33-252.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8ZA34. 1 interaction.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1148790. 1176824. 2764894.
GenomeReviews	Gene locus y3843 in contig AE009952_GR. Gene locus YP_3349 in contig AE017042_GR. Gene locus YPO3986 in contig AL590842_GR.
KEGG	ype:YPO3986. ypk:y3843. ypm:YP_3349.
Phylogenomic databases
HOGENOM	HBG565233.
OMA	DINGPLQ.
ProtClustDB	PRK05471.
Enzyme and pathway databases
BioCyc	YPES187410:Y3843-MONOMER. YPES214092:YPO3986-MONOMER.
Family and domain databases
HAMAP	MF_00319. Cdh. [Tree]
InterPro	IPR003763. CDP-diacylglyc_Pase. [Graphical view]
KO	K01521.
Pfam	PF02611. CDH. 1 hit. [Graphical view]
PIRSF	PIRSF001273. CDH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CDH_YERPE

Accession

Primary (citable) accession number: Q8ZA34
Secondary accession number(s): Q0WA32

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	March 1, 2002
Last modified:	November 16, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program