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Protein

Membrane protein insertase YidC

Gene

yidC

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYPES214092:GKDD-4065-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein insertase YidCUniRule annotation
Alternative name(s):
Foldase YidCUniRule annotation
Membrane integrase YidCUniRule annotation
Membrane protein YidCUniRule annotation
Gene namesi
Name:yidCUniRule annotation
Ordered Locus Names:YPO4102, y4117, YP_4009
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalUniRule annotationAdd
BLAST
Transmembranei344 – 36421HelicalUniRule annotationAdd
BLAST
Transmembranei419 – 43921HelicalUniRule annotationAdd
BLAST
Transmembranei457 – 47721HelicalUniRule annotationAdd
BLAST
Transmembranei498 – 51821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 546546Membrane protein insertase YidCPRO_0000124775Add
BLAST

Proteomic databases

PRIDEiQ8Z9U3.

Interactioni

Subunit structurei

Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.UniRule annotation

Protein-protein interaction databases

IntActiQ8Z9U3. 1 interaction.
STRINGi187410.y4117.

Structurei

3D structure databases

ProteinModelPortaliQ8Z9U3.
SMRiQ8Z9U3. Positions 56-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DHW. Bacteria.
COG0706. LUCA.
HOGENOMiHOG000101822.
KOiK03217.
OMAiQFMPLVF.
OrthoDBiEOG6X6RF2.

Family and domain databases

HAMAPiMF_01810. YidC_type1.
InterProiIPR019998. Membr_insert_YidC.
IPR028055. Membr_insert_YidC/Oxa1_C.
IPR028053. Membr_insert_YidC_N.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 1 hit.
PfamiPF02096. 60KD_IMP. 1 hit.
PF14849. YidC_periplas. 1 hit.
[Graphical view]
PRINTSiPR00701. 60KDINNERMP.
PR01900. YIDCPROTEIN.
TIGRFAMsiTIGR03593. yidC_nterm. 1 hit.
TIGR03592. yidC_oxa1_cterm. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8Z9U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSQRNLLLI ALLFVSFMIW QAWQVDNNPQ PTAQTTQQTT NTATGDKASQ
60 70 80 90 100
AVPGSGQGQL ITVKTDVLSL TINTRGGDIE QANLLAYPDT LGSSNTFELL
110 120 130 140 150
ETTPSFVYQA QSGLTGKNGP DNPANGDRPL FEVPQTSFVL ADGQDELRIP
160 170 180 190 200
LTFTSKDGSV FIKTFVLKRN DYAIGVDYHV NNASAAPLEL TLFGQLKQSI
210 220 230 240 250
NLPKKRDTGS NNFALQTYRG AAYSSDETKY KKYSFSDIED KNLDITTKGG
260 270 280 290 300
WVAMLQQYFA TAWIPAANET NTFYSAELGN GLAAIGFKGA PVVIQPGEQK
310 320 330 340 350
QLSATLWVGP EIQNKMAEIA PHLDLTVDYG WLWFISQPLF KLLKFIHSFV
360 370 380 390 400
GNWGFSIIVI TFIVRGIMYP LTKAQYTSMA KMRLLQPKLA AMRERIGDDK
410 420 430 440 450
QRMSQEMMAL YKAEKVNPLG GCLPLIIQMP IFLALYYMLM SSVELRHAPF
460 470 480 490 500
ILWIHDLSAQ DPYYILPILM GITMYFIQKM SPTTVTDPMQ QKIMTFMPVI
510 520 530 540
FTVFFLWFPA GLVLYYIVSN LVTILQQQLI YRGLEKRGLH SREKKK
Length:546
Mass (Da):61,291
Last modified:March 1, 2002 - v1
Checksum:i607C8EB233496827
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL22670.1.
AE009952 Genomic DNA. Translation: AAM87658.1.
AE017042 Genomic DNA. Translation: AAS64148.1.
PIRiAB0498.
RefSeqiWP_002220739.1. NZ_LIXY01000016.1.
YP_002348953.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM87658; AAM87658; y4117.
AAS64148; AAS64148; YP_4009.
GeneIDi1176930.
KEGGiype:YPO4102.
ypj:CH55_2784.
ypk:y4117.
ypl:CH46_946.
ypm:YP_4009.
ypv:BZ15_3600.
ypw:CH59_2059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL22670.1.
AE009952 Genomic DNA. Translation: AAM87658.1.
AE017042 Genomic DNA. Translation: AAS64148.1.
PIRiAB0498.
RefSeqiWP_002220739.1. NZ_LIXY01000016.1.
YP_002348953.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ8Z9U3.
SMRiQ8Z9U3. Positions 56-340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8Z9U3. 1 interaction.
STRINGi187410.y4117.

Proteomic databases

PRIDEiQ8Z9U3.

Protocols and materials databases

DNASUi1149063.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM87658; AAM87658; y4117.
AAS64148; AAS64148; YP_4009.
GeneIDi1176930.
KEGGiype:YPO4102.
ypj:CH55_2784.
ypk:y4117.
ypl:CH46_946.
ypm:YP_4009.
ypv:BZ15_3600.
ypw:CH59_2059.

Phylogenomic databases

eggNOGiENOG4105DHW. Bacteria.
COG0706. LUCA.
HOGENOMiHOG000101822.
KOiK03217.
OMAiQFMPLVF.
OrthoDBiEOG6X6RF2.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-4065-MONOMER.

Family and domain databases

HAMAPiMF_01810. YidC_type1.
InterProiIPR019998. Membr_insert_YidC.
IPR028055. Membr_insert_YidC/Oxa1_C.
IPR028053. Membr_insert_YidC_N.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 1 hit.
PfamiPF02096. 60KD_IMP. 1 hit.
PF14849. YidC_periplas. 1 hit.
[Graphical view]
PRINTSiPR00701. 60KDINNERMP.
PR01900. YIDCPROTEIN.
TIGRFAMsiTIGR03593. yidC_nterm. 1 hit.
TIGR03592. yidC_oxa1_cterm. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiYIDC_YERPE
AccessioniPrimary (citable) accession number: Q8Z9U3
Secondary accession number(s): Q0W9T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.