Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei604For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:YPO4118, y4132, YP_4025
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001354182 – 609Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST608

Proteomic databases

PaxDbiQ8Z9S8
PRIDEiQ8Z9S8

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ8Z9S8, 1 interactor
STRINGi187410.y4132

Structurei

3D structure databases

ProteinModelPortaliQ8Z9S8
SMRiQ8Z9S8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 218Glutamine amidotransferase type-2UniRule annotationAdd BLAST217
Domaini286 – 426SIS 1UniRule annotationAdd BLAST141
Domaini458 – 599SIS 2UniRule annotationAdd BLAST142

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258898
KOiK00820
OMAiASEYRYA

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8Z9S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGAVAQ RDIAEILIEG LRRLEYRGYD SAGLAVVDSE GHLTRLRRVG
60 70 80 90 100
KVHALSDAAE KQDLHGGTGI AHTRWATHGE PSEANAHPHV SDYISVVHNG
110 120 130 140 150
IIENHEPLRE LLISRGYRFS SETDTEVIAH LVHWEQQQGG SLLEVVKRVI
160 170 180 190 200
PQLRGAYGTV VMDSRDPSRL IAARSGSPLV IGCGVGENFI ASDQLALLPV
210 220 230 240 250
TRRFIFLEEG DVVEVTRRSI SIFDKQGNAI ERPEIESQVQ YDAGDKGIYR
260 270 280 290 300
HYMQKEIYEQ PMAIKNTLEG RLSHGMIDLS ELGPKADALL AEVQHIQIIA
310 320 330 340 350
CGTSYNSGMV SRYWFESLAG VPCDVEIASE FRYRKSAVRP NSLLITLSQS
360 370 380 390 400
GETADTLAAL RLSKELGYLG SLAICNVAGS SLVRESDLAL MTKAGTEIGV
410 420 430 440 450
ASTKAFTTQL TVLLMLVGRI GKLKGADASL EHDIVHALQA LPARIEQMLS
460 470 480 490 500
LDKTIEALAE GFSDKHHALF LGRGDQYPIA MEGALKLKEI SYIHAEAYAA
510 520 530 540 550
GELKHGPLAL IDADMPVIVV APNNELLEKL KSNIEEVRAR GGLLYVFADQ
560 570 580 590 600
DAGFTDSEGM KIIQLPHVEE IIAPIFYTVP LQLLSYHVAL IKGTDVDQPR

NLAKSVTVE
Length:609
Mass (Da):66,525
Last modified:January 23, 2007 - v3
Checksum:i3EB0B5ACEE758B7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL22686.1
AE009952 Genomic DNA Translation: AAM87674.1
AE017042 Genomic DNA Translation: AAS64164.1
PIRiAB0500
RefSeqiWP_002215552.1, NZ_PDBR01000028.1
YP_002348969.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM87674; AAM87674; y4132
AAS64164; AAS64164; YP_4025
GeneIDi1176946
KEGGiype:YPO4118
ypk:y4132
ypm:YP_4025
PATRICifig|214092.21.peg.4662

Similar proteinsi

Entry informationi

Entry nameiGLMS_YERPE
AccessioniPrimary (citable) accession number: Q8Z9S8
Secondary accession number(s): Q0W9R9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health