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Protein
Submitted name:

Aspartokinase I

Gene

thrA

Organism
Salmonella typhi
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. aspartate kinase activity Source: InterPro
  3. homoserine dehydrogenase activity Source: InterPro
  4. NADP binding Source: InterPro

GO - Biological processi

  1. aspartate family amino acid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Aspartokinase IImported
Submitted name:
Aspartokinase I/homoserine dehydrogenase IImported
Gene namesi
Name:thrAImported
Ordered Locus Names:STY0002Imported, t0002Imported
OrganismiSalmonella typhiImported
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000002670 Componenti: Chromosome UP000000541 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi220341.STY0002.

Structurei

3D structure databases

ProteinModelPortaliQ8Z9R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000271593.
KOiK12524.
OMAiQAYDESS.
OrthoDBiEOG6M0T34.

Family and domain databases

Gene3Di3.40.1160.10. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR002912. ACT_dom.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR005106. Asp/hSer_DH_NAD-bd.
IPR001341. Asp_kinase_dom.
IPR018042. Aspartate_kinase_CS.
IPR011147. Bifunc_aspartokin/hSer_DH.
IPR027795. GATS-like_ACT_dom.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF13840. ACT_7. 2 hits.
PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000727. ThrA. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00657. asp_kinases. 1 hit.
PROSITEiPS51671. ACT. 2 hits.
PS00324. ASPARTOKINASE. 1 hit.
PS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8Z9R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLKFGGTS VANAERFLRV ADILESNSRQ GQVATVLSAP AKITNHLVAM
60 70 80 90 100
IEKTIGGQDA LPNISDAERI FSDLLAGLAS AQPGFPLARL KMVVEQEFAQ
110 120 130 140 150
IKHVLHGISL LGQCPDSINA ALICRGEKMS IAIMAGLLEA RGHRVTVIDP
160 170 180 190 200
VEKLLAVGHY LESTVDIAES TRRIAASQIP ADHMILMAGF TAGNEKGELV
210 220 230 240 250
VLGRNGSDYS AAVLAACLRA DCCEIWTDVD GVYTCDPRQV PDARLLKSMS
260 270 280 290 300
YQEAMELSYF GAKVLHPRTI TPIAQFQIPC LIKNTGNPQA PGTLIGASSD
310 320 330 340 350
DDNLPVKGIS NLNNMAMFSV SGPGMKGMIG MAARVFAAMS RAGISVVLIT
360 370 380 390 400
QSSSEYSISF CVPQSDCARA RRAMQDEFYL ELKEGLLEPL AVTERLAIIS
410 420 430 440 450
VVGDGMRTLR GISAKFFAAL ARANINIVAI AQGSSERSIS VVVNNDDATT
460 470 480 490 500
GVRVTHQMLF NTDQVIEVFV IGVGGVGGAL LEQLKRQQTW LKNKHIDLRV
510 520 530 540 550
CGVANSKALL TNVHGLNLDN WQAELAQANA PFNLGRLIRL VKEYHLLNPV
560 570 580 590 600
IVDCTSSQAV ADQYADFLRE GFHVVTPNKK ANTSSMDYYH QLRFAAAQSR
610 620 630 640 650
RKFLYDTNVG AGLPVIENLQ NLLNAGDELQ KFSGILSGSL SFIFGKLEEG
660 670 680 690 700
MSLSQATALA REMGYTEPDP RDDLSGMDVA RKLLILARET GRELELSDIV
710 720 730 740 750
IEPVLPDEFD ASGDVTAFMA HLPQLDDAFA ARVAKARDEG KVLRYVGNIE
760 770 780 790 800
EDGVCRVKIA EVDGNDPLFK VKNGENALAF YSHYYQPLPL VLRGYGAGND
810 820
VTAAGVFADL LRTLSWKLGV
Length:820
Mass (Da):88,712
Last modified:March 1, 2002 - v1
Checksum:iED6CDB2F6F01AC67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014613 Genomic DNA. Translation: AAO67736.1.
AL513382 Genomic DNA. Translation: CAD01155.1.
RefSeqiNP_454612.1. NC_003198.1.
NP_803887.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO67736; AAO67736; t0002.
CAD01155; CAD01155; CAD01155.
GeneIDi1246513.
KEGGisty:STY0002.
PATRICi18537815. VBISalEnt120419_0001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014613 Genomic DNA. Translation: AAO67736.1.
AL513382 Genomic DNA. Translation: CAD01155.1.
RefSeqiNP_454612.1. NC_003198.1.
NP_803887.1. NC_004631.1.

3D structure databases

ProteinModelPortaliQ8Z9R7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220341.STY0002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO67736; AAO67736; t0002.
CAD01155; CAD01155; CAD01155.
GeneIDi1246513.
KEGGisty:STY0002.
PATRICi18537815. VBISalEnt120419_0001.

Phylogenomic databases

HOGENOMiHOG000271593.
KOiK12524.
OMAiQAYDESS.
OrthoDBiEOG6M0T34.

Family and domain databases

Gene3Di3.40.1160.10. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR002912. ACT_dom.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR005106. Asp/hSer_DH_NAD-bd.
IPR001341. Asp_kinase_dom.
IPR018042. Aspartate_kinase_CS.
IPR011147. Bifunc_aspartokin/hSer_DH.
IPR027795. GATS-like_ACT_dom.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF13840. ACT_7. 2 hits.
PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000727. ThrA. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00657. asp_kinases. 1 hit.
PROSITEiPS51671. ACT. 2 hits.
PS00324. ASPARTOKINASE. 1 hit.
PS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18Imported.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2Imported and Ty2Imported.

Entry informationi

Entry nameiQ8Z9R7_SALTI
AccessioniPrimary (citable) accession number: Q8Z9R7
Secondary accession number(s): Q7CBW4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: April 1, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.