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Q8Z9C3 (PCNB_SALTI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Poly(A) polymerase I

Short name=PAP I
EC=2.7.7.19
Gene names
Name:pcnB
Ordered Locus Names:STY0209, t0192
OrganismSalmonella typhi [Complete proteome] [HAMAP]
Taxonomic identifier90370 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control By similarity. HAMAP-Rule MF_00957

Catalytic activity

ATP + RNA(n) = diphosphate + RNA(n+1). HAMAP-Rule MF_00957

Sequence similarities

Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

Sequence caution

The sequence AAO67924.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence CAD01345.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 465465Poly(A) polymerase I HAMAP-Rule MF_00957
PRO_0000139094

Sites

Active site801 By similarity
Active site821 By similarity
Active site1621 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8Z9C3 [UniParc].

Last modified September 19, 2006. Version 2.
Checksum: A94E6DFAFBC83720

FASTA46553,902
        10         20         30         40         50         60 
MFTRVANFCR KVLSREESEA EQAVARPHMT IIPREQHAIS RKDISENALK VLYRLNKAGY 

        70         80         90        100        110        120 
EAYLVGGGVR DLLLGKKPKD FDVTTNATPD QVRKLFRNCR LVGRRFRLAH VMFGPEIIEV 

       130        140        150        160        170        180 
ATFRGHNEGS ESDRTTSQRG QNGMLLRDNI FGSIEEDAQR RDFTINSLYY SVADFTVRDY 

       190        200        210        220        230        240 
VGGMQDLQEG VIRLIGNPET RYREDPVRML RAVRFAAKLN MRISPETAEP IPRLATLLND 

       250        260        270        280        290        300 
IPPARLFEES LKLLQAGNGF ETYQQLREYH LFQPLFPTIT RYFTENGDSA MERIIAQVLK 

       310        320        330        340        350        360 
NTDNRIRNEM RVNPAFLFAA MFWYPLLEMA QKIAQESGLA YYDAFALAMN DVLDEACRSL 

       370        380        390        400        410        420 
AIPKRLTTLT RDIWQLQLRM SRRQGKRAWK LMEHPKFRAA FDLLELRAQV ENNTELQRLA 

       430        440        450        460 
QWWAEFQASA PPEQKGMLNE LDDDPAPRRR RSRPRKRAPR REGTV 

« Hide

References

[1]"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18."
Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. expand/collapse author list , Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:848-852(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CT18.
[2]"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700931 / Ty2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL513382 Genomic DNA. Translation: CAD01345.1. Different initiation.
AE014613 Genomic DNA. Translation: AAO67924.1. Different initiation.
RefSeqNP_454800.1. NC_003198.1.
NP_804075.1. NC_004631.1.

3D structure databases

ProteinModelPortalQ8Z9C3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220341.STY0209.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO67924; AAO67924; t0192.
CAD01345; CAD01345; CAD01345.
GeneID1246703.
PATRIC18538240. VBISalEnt120419_0212.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0617.
HOGENOMHOG000256527.
KOK00970.
OMARFMAKLD.
OrthoDBEOG6PZX7Q.
ProtClustDBPRK11623.

Family and domain databases

HAMAPMF_00957. PolyA_pol.
InterProIPR026007. PcnB/CCA-adding.
IPR002646. PolA_pol_head_dom.
IPR010206. PolA_pol_I.
IPR025866. PolyA_pol_arg_C_dom.
[Graphical view]
PANTHERPTHR13734:SF5. PTHR13734:SF5. 1 hit.
PfamPF01743. PolyA_pol. 1 hit.
PF12626. PolyA_pol_arg_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR01942. pcnB. 1 hit.
ProtoNetSearch...

Entry information

Entry namePCNB_SALTI
AccessionPrimary (citable) accession number: Q8Z9C3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: September 19, 2006
Last modified: April 16, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families