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Q8Z9C3

- PCNB_SALTI

UniProt

Q8Z9C3 - PCNB_SALTI

Protein

Poly(A) polymerase I

Gene

pcnB

Organism
Salmonella typhi
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (19 Sep 2006)
      Previous versions | rss
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    Functioni

    Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.UniRule annotation

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei80 – 801UniRule annotation
    Active sitei82 – 821UniRule annotation
    Active sitei162 – 1621UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. polynucleotide adenylyltransferase activity Source: UniProtKB-HAMAP
    3. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA polyadenylation Source: InterPro
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing, Transcription

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase IUniRule annotation (EC:2.7.7.19UniRule annotation)
    Short name:
    PAP IUniRule annotation
    Gene namesi
    Name:pcnBUniRule annotation
    Ordered Locus Names:STY0209, t0192
    OrganismiSalmonella typhi
    Taxonomic identifieri90370 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 465465Poly(A) polymerase IPRO_0000139094Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi220341.STY0209.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8Z9C3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0617.
    HOGENOMiHOG000256527.
    KOiK00970.
    OMAiRFMAKLD.
    OrthoDBiEOG6PZX7Q.

    Family and domain databases

    HAMAPiMF_00957. PolyA_pol.
    InterProiIPR002646. PolA_pol_head_dom.
    IPR010206. PolA_pol_I.
    IPR025866. PolyA_pol_arg_C_dom.
    [Graphical view]
    PfamiPF01743. PolyA_pol. 1 hit.
    PF12626. PolyA_pol_arg_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01942. pcnB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8Z9C3-1 [UniParc]FASTAAdd to Basket

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    MFTRVANFCR KVLSREESEA EQAVARPHMT IIPREQHAIS RKDISENALK    50
    VLYRLNKAGY EAYLVGGGVR DLLLGKKPKD FDVTTNATPD QVRKLFRNCR 100
    LVGRRFRLAH VMFGPEIIEV ATFRGHNEGS ESDRTTSQRG QNGMLLRDNI 150
    FGSIEEDAQR RDFTINSLYY SVADFTVRDY VGGMQDLQEG VIRLIGNPET 200
    RYREDPVRML RAVRFAAKLN MRISPETAEP IPRLATLLND IPPARLFEES 250
    LKLLQAGNGF ETYQQLREYH LFQPLFPTIT RYFTENGDSA MERIIAQVLK 300
    NTDNRIRNEM RVNPAFLFAA MFWYPLLEMA QKIAQESGLA YYDAFALAMN 350
    DVLDEACRSL AIPKRLTTLT RDIWQLQLRM SRRQGKRAWK LMEHPKFRAA 400
    FDLLELRAQV ENNTELQRLA QWWAEFQASA PPEQKGMLNE LDDDPAPRRR 450
    RSRPRKRAPR REGTV 465
    Length:465
    Mass (Da):53,902
    Last modified:September 19, 2006 - v2
    Checksum:iA94E6DFAFBC83720
    GO

    Sequence cautioni

    The sequence AAO67924.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAD01345.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD01345.1. Different initiation.
    AE014613 Genomic DNA. Translation: AAO67924.1. Different initiation.
    RefSeqiNP_454800.1. NC_003198.1.
    NP_804075.1. NC_004631.1.

    Genome annotation databases

    EnsemblBacteriaiAAO67924; AAO67924; t0192.
    CAD01345; CAD01345; CAD01345.
    GeneIDi1246703.
    KEGGisty:STY0209.
    PATRICi18538240. VBISalEnt120419_0212.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD01345.1 . Different initiation.
    AE014613 Genomic DNA. Translation: AAO67924.1 . Different initiation.
    RefSeqi NP_454800.1. NC_003198.1.
    NP_804075.1. NC_004631.1.

    3D structure databases

    ProteinModelPortali Q8Z9C3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220341.STY0209.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO67924 ; AAO67924 ; t0192 .
    CAD01345 ; CAD01345 ; CAD01345 .
    GeneIDi 1246703.
    KEGGi sty:STY0209.
    PATRICi 18538240. VBISalEnt120419_0212.

    Phylogenomic databases

    eggNOGi COG0617.
    HOGENOMi HOG000256527.
    KOi K00970.
    OMAi RFMAKLD.
    OrthoDBi EOG6PZX7Q.

    Family and domain databases

    HAMAPi MF_00957. PolyA_pol.
    InterProi IPR002646. PolA_pol_head_dom.
    IPR010206. PolA_pol_I.
    IPR025866. PolyA_pol_arg_C_dom.
    [Graphical view ]
    Pfami PF01743. PolyA_pol. 1 hit.
    PF12626. PolyA_pol_arg_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01942. pcnB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CT18.
    2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
      Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
      J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700931 / Ty2.

    Entry informationi

    Entry nameiPCNB_SALTI
    AccessioniPrimary (citable) accession number: Q8Z9C3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: September 19, 2006
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3