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Q8Z903

- PRPD_SALTI

UniProt

Q8Z903 - PRPD_SALTI

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Protein
2-methylcitrate dehydratase
Gene
prpD, STY0402, t2494
Organism
Salmonella typhi
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dehydration of 2-methylcitrate to 2-methyl-cis-aconitate By similarity.

Catalytic activityi

(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.

Cofactori

Binds 1 2Fe-2S cluster By similarity.

Pathwayi

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 2-methylcitrate dehydratase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. propionate catabolic process, 2-methylcitrate cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00946.

Names & Taxonomyi

Protein namesi
Recommended name:
2-methylcitrate dehydratase (EC:4.2.1.79)
Gene namesi
Name:prpD
Ordered Locus Names:STY0402, t2494
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4834832-methylcitrate dehydratase
PRO_0000215025Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi220341.STY0402.

Structurei

3D structure databases

ProteinModelPortaliQ8Z903.
SMRiQ8Z903. Positions 11-483.

Family & Domainsi

Sequence similaritiesi

Belongs to the PrpD family.

Phylogenomic databases

eggNOGiCOG2079.
HOGENOMiHOG000159916.
KOiK01720.
OMAiTAPQWGF.
OrthoDBiEOG6RC3K5.

Family and domain databases

InterProiIPR012705. 2Me_IsoCit_deHydtase_PrpD.
IPR005656. MmgE_PrpD.
[Graphical view]
PANTHERiPTHR16943. PTHR16943. 1 hit.
PfamiPF03972. MmgE_PrpD. 1 hit.
[Graphical view]
SUPFAMiSSF103378. SSF103378. 1 hit.
TIGRFAMsiTIGR02330. prpD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8Z903-1 [UniParc]FASTAAdd to Basket

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MSAHISNVRP DFDREIVDIV DYVMNYEITS KVAYDTAHYC LLDTLGCGLE    50
ALEYPACKKL LGPIVPGTVV PNGARVPGTQ FQLDPVQAAF NISAMIRWLD 100
FNDTWLAAEW GHPSDNLGGI LATADWLSRN AVAAGKAPLT MKQVLSGMIK 150
AHEIQGCIAL ENAFNRVGLD HVLLVKVAST AVVAEMLGLT RDEILNAVSL 200
AWVDGQSLRT YRHAPNTGTR KSWAAGDATS RAVRLALMAK TGEMGYPSAL 250
TAKTWGFYDV SFKGETFRFQ RPYGSYVMEN VLFKISFPAE FHSQTAVEAA 300
MTLYEQMQAA GKTAADIEKV TIRTHEACLR IIDKKGPLNN PADRDHCIQY 350
MVAVPLLFGR LTAADYEDEV AQDKRIDALR EKIVCYEDPA FTADYHDPEK 400
RAIGNAITVE FTDGSRFGEV VVEYPIGHAR RRADGIPKLI EKFKINLARQ 450
FLTRQQQRIL DVSLDRARLE QMPVNEYLDL YII 483
Length:483
Mass (Da):53,770
Last modified:March 1, 2002 - v1
Checksum:i4C695F381E7E228A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti452 – 4521L → P in AAO70082. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD08825.1.
AE014613 Genomic DNA. Translation: AAO70082.1.
RefSeqiNP_454965.1. NC_003198.1.
NP_806222.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO70082; AAO70082; t2494.
CAD08825; CAD08825; CAD08825.
GeneIDi1246882.
KEGGisty:STY0402.
PATRICi18538628. VBISalEnt120419_0398.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD08825.1 .
AE014613 Genomic DNA. Translation: AAO70082.1 .
RefSeqi NP_454965.1. NC_003198.1.
NP_806222.1. NC_004631.1.

3D structure databases

ProteinModelPortali Q8Z903.
SMRi Q8Z903. Positions 11-483.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220341.STY0402.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO70082 ; AAO70082 ; t2494 .
CAD08825 ; CAD08825 ; CAD08825 .
GeneIDi 1246882.
KEGGi sty:STY0402.
PATRICi 18538628. VBISalEnt120419_0398.

Phylogenomic databases

eggNOGi COG2079.
HOGENOMi HOG000159916.
KOi K01720.
OMAi TAPQWGF.
OrthoDBi EOG6RC3K5.

Enzyme and pathway databases

UniPathwayi UPA00946 .

Family and domain databases

InterProi IPR012705. 2Me_IsoCit_deHydtase_PrpD.
IPR005656. MmgE_PrpD.
[Graphical view ]
PANTHERi PTHR16943. PTHR16943. 1 hit.
Pfami PF03972. MmgE_PrpD. 1 hit.
[Graphical view ]
SUPFAMi SSF103378. SSF103378. 1 hit.
TIGRFAMsi TIGR02330. prpD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiPRPD_SALTI
AccessioniPrimary (citable) accession number: Q8Z903
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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