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Q8Z903

- PRPD_SALTI

UniProt

Q8Z903 - PRPD_SALTI

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Protein

2-methylcitrate dehydratase

Gene

prpD

Organism
Salmonella typhi
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dehydration of 2-methylcitrate to 2-methyl-cis-aconitate.By similarity

Catalytic activityi

(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.

Cofactori

Binds 1 2Fe-2S cluster.By similarity

Pathwayi

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 2-methylcitrate dehydratase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. propionate catabolic process, 2-methylcitrate cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00946.

Names & Taxonomyi

Protein namesi
Recommended name:
2-methylcitrate dehydratase (EC:4.2.1.79)
Gene namesi
Name:prpD
Ordered Locus Names:STY0402, t2494
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4834832-methylcitrate dehydratasePRO_0000215025Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi220341.STY0402.

Structurei

3D structure databases

ProteinModelPortaliQ8Z903.
SMRiQ8Z903. Positions 11-483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PrpD family.Curated

Phylogenomic databases

eggNOGiCOG2079.
HOGENOMiHOG000159916.
KOiK01720.
OMAiTAPQWGF.
OrthoDBiEOG6RC3K5.

Family and domain databases

InterProiIPR012705. 2Me_IsoCit_deHydtase_PrpD.
IPR005656. MmgE_PrpD.
[Graphical view]
PANTHERiPTHR16943. PTHR16943. 1 hit.
PfamiPF03972. MmgE_PrpD. 1 hit.
[Graphical view]
SUPFAMiSSF103378. SSF103378. 1 hit.
TIGRFAMsiTIGR02330. prpD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8Z903-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAHISNVRP DFDREIVDIV DYVMNYEITS KVAYDTAHYC LLDTLGCGLE
60 70 80 90 100
ALEYPACKKL LGPIVPGTVV PNGARVPGTQ FQLDPVQAAF NISAMIRWLD
110 120 130 140 150
FNDTWLAAEW GHPSDNLGGI LATADWLSRN AVAAGKAPLT MKQVLSGMIK
160 170 180 190 200
AHEIQGCIAL ENAFNRVGLD HVLLVKVAST AVVAEMLGLT RDEILNAVSL
210 220 230 240 250
AWVDGQSLRT YRHAPNTGTR KSWAAGDATS RAVRLALMAK TGEMGYPSAL
260 270 280 290 300
TAKTWGFYDV SFKGETFRFQ RPYGSYVMEN VLFKISFPAE FHSQTAVEAA
310 320 330 340 350
MTLYEQMQAA GKTAADIEKV TIRTHEACLR IIDKKGPLNN PADRDHCIQY
360 370 380 390 400
MVAVPLLFGR LTAADYEDEV AQDKRIDALR EKIVCYEDPA FTADYHDPEK
410 420 430 440 450
RAIGNAITVE FTDGSRFGEV VVEYPIGHAR RRADGIPKLI EKFKINLARQ
460 470 480
FLTRQQQRIL DVSLDRARLE QMPVNEYLDL YII
Length:483
Mass (Da):53,770
Last modified:March 1, 2002 - v1
Checksum:i4C695F381E7E228A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti452 – 4521L → P in AAO70082. (PubMed:12644504)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD08825.1.
AE014613 Genomic DNA. Translation: AAO70082.1.
RefSeqiNP_454965.1. NC_003198.1.
NP_806222.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO70082; AAO70082; t2494.
CAD08825; CAD08825; CAD08825.
GeneIDi1246882.
KEGGisty:STY0402.
PATRICi18538628. VBISalEnt120419_0398.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD08825.1 .
AE014613 Genomic DNA. Translation: AAO70082.1 .
RefSeqi NP_454965.1. NC_003198.1.
NP_806222.1. NC_004631.1.

3D structure databases

ProteinModelPortali Q8Z903.
SMRi Q8Z903. Positions 11-483.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220341.STY0402.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO70082 ; AAO70082 ; t2494 .
CAD08825 ; CAD08825 ; CAD08825 .
GeneIDi 1246882.
KEGGi sty:STY0402.
PATRICi 18538628. VBISalEnt120419_0398.

Phylogenomic databases

eggNOGi COG2079.
HOGENOMi HOG000159916.
KOi K01720.
OMAi TAPQWGF.
OrthoDBi EOG6RC3K5.

Enzyme and pathway databases

UniPathwayi UPA00946 .

Family and domain databases

InterProi IPR012705. 2Me_IsoCit_deHydtase_PrpD.
IPR005656. MmgE_PrpD.
[Graphical view ]
PANTHERi PTHR16943. PTHR16943. 1 hit.
Pfami PF03972. MmgE_PrpD. 1 hit.
[Graphical view ]
SUPFAMi SSF103378. SSF103378. 1 hit.
TIGRFAMsi TIGR02330. prpD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiPRPD_SALTI
AccessioniPrimary (citable) accession number: Q8Z903
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3