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Q8Z8W3

- PANE_SALTI

UniProt

Q8Z8W3 - PANE_SALTI

Protein

2-dehydropantoate 2-reductase

Gene

panE

Organism
Salmonella typhi
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (21 Feb 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

    Catalytic activityi

    (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei31 – 311NADP; via amide nitrogenBy similarity
    Binding sitei98 – 981NADP; via amide nitrogenBy similarity
    Binding sitei98 – 981SubstrateBy similarity
    Binding sitei122 – 1221NADP; via amide nitrogen and carbonyl oxygenBy similarity
    Active sitei176 – 1761Proton donor
    Binding sitei180 – 1801SubstrateBy similarity
    Binding sitei184 – 1841SubstrateBy similarity
    Binding sitei194 – 1941SubstrateBy similarity
    Binding sitei241 – 2411SubstrateBy similarity
    Binding sitei244 – 2441SubstrateBy similarity
    Binding sitei256 – 2561NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 126NADPBy similarity

    GO - Molecular functioni

    1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00028; UER00004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-dehydropantoate 2-reductase (EC:1.1.1.169)
    Alternative name(s):
    Ketopantoate reductase
    Short name:
    KPA reductase
    Short name:
    KPR
    Gene namesi
    Name:panE
    Synonyms:apbA
    Ordered Locus Names:STY0473, t2430
    OrganismiSalmonella typhi
    Taxonomic identifieri90370 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3033032-dehydropantoate 2-reductasePRO_0000157303Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi220341.STY0473.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8Z8W3.
    SMRiQ8Z8W3. Positions 1-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketopantoate reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1893.
    HOGENOMiHOG000050223.
    KOiK00077.
    OMAiIEFINGW.
    OrthoDBiEOG68SVW3.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8Z8W3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKITVLGCGA LGQLWLSALC KHGHDVQGWL RVPQPYCSVN LIDTDGSFFN    50
    ESLTANDPDF LAKSELLLVT LKAWQVSDAV RTLASTLPVT SPILLIHNGM 100
    GTIEELQSIQ QPMLMGAITH AARRDGNIII HVANGTTHIG PAREQDGDYS 150
    YLAEILQGVL PDVAWHNNIR AEMWRKLAVN CVINPLTALW NCPNGELRHH 200
    TDEINAICEE VAAVIEREGY HTSADDLCYY VEQVIDSTAE NISSMLQDVR 250
    AMRHTEIDYI TGYLLKRARV HGLAVPENSR LFEMVKRKES EYERSGTGMP 300
    RPW 303
    Length:303
    Mass (Da):33,842
    Last modified:February 21, 2002 - v1
    Checksum:i0369C148A42BF583
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti117 – 1171A → T in AAO70019. (PubMed:12644504)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD08890.1.
    AE014613 Genomic DNA. Translation: AAO70019.1.
    RefSeqiNP_455028.1. NC_003198.1.
    NP_806159.1. NC_004631.1.

    Genome annotation databases

    EnsemblBacteriaiAAO70019; AAO70019; t2430.
    CAD08890; CAD08890; CAD08890.
    GeneIDi1246947.
    KEGGisty:STY0473.
    PATRICi18538780. VBISalEnt120419_0474.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD08890.1 .
    AE014613 Genomic DNA. Translation: AAO70019.1 .
    RefSeqi NP_455028.1. NC_003198.1.
    NP_806159.1. NC_004631.1.

    3D structure databases

    ProteinModelPortali Q8Z8W3.
    SMRi Q8Z8W3. Positions 1-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220341.STY0473.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO70019 ; AAO70019 ; t2430 .
    CAD08890 ; CAD08890 ; CAD08890 .
    GeneIDi 1246947.
    KEGGi sty:STY0473.
    PATRICi 18538780. VBISalEnt120419_0474.

    Phylogenomic databases

    eggNOGi COG1893.
    HOGENOMi HOG000050223.
    KOi K00077.
    OMAi IEFINGW.
    OrthoDBi EOG68SVW3.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00004 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CT18.
    2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
      Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
      J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700931 / Ty2.

    Entry informationi

    Entry nameiPANE_SALTI
    AccessioniPrimary (citable) accession number: Q8Z8W3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: February 21, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3