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Q8Z8W3

- PANE_SALTI

UniProt

Q8Z8W3 - PANE_SALTI

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Protein

2-dehydropantoate 2-reductase

Gene
panE, apbA, STY0473, t2430
Organism
Salmonella typhi
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311NADP; via amide nitrogen By similarity
Binding sitei98 – 981NADP; via amide nitrogen By similarity
Binding sitei98 – 981Substrate By similarity
Binding sitei122 – 1221NADP; via amide nitrogen and carbonyl oxygen By similarity
Active sitei176 – 1761Proton donor
Binding sitei180 – 1801Substrate By similarity
Binding sitei184 – 1841Substrate By similarity
Binding sitei194 – 1941Substrate By similarity
Binding sitei241 – 2411Substrate By similarity
Binding sitei244 – 2441Substrate By similarity
Binding sitei256 – 2561NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NADP By similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Name:panE
Synonyms:apbA
Ordered Locus Names:STY0473, t2430
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3033032-dehydropantoate 2-reductasePRO_0000157303Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi220341.STY0473.

Structurei

3D structure databases

ProteinModelPortaliQ8Z8W3.
SMRiQ8Z8W3. Positions 1-293.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050223.
KOiK00077.
OMAiIEFINGW.
OrthoDBiEOG68SVW3.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8Z8W3-1 [UniParc]FASTAAdd to Basket

« Hide

MKITVLGCGA LGQLWLSALC KHGHDVQGWL RVPQPYCSVN LIDTDGSFFN    50
ESLTANDPDF LAKSELLLVT LKAWQVSDAV RTLASTLPVT SPILLIHNGM 100
GTIEELQSIQ QPMLMGAITH AARRDGNIII HVANGTTHIG PAREQDGDYS 150
YLAEILQGVL PDVAWHNNIR AEMWRKLAVN CVINPLTALW NCPNGELRHH 200
TDEINAICEE VAAVIEREGY HTSADDLCYY VEQVIDSTAE NISSMLQDVR 250
AMRHTEIDYI TGYLLKRARV HGLAVPENSR LFEMVKRKES EYERSGTGMP 300
RPW 303
Length:303
Mass (Da):33,842
Last modified:February 21, 2002 - v1
Checksum:i0369C148A42BF583
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1171A → T in AAO70019. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD08890.1.
AE014613 Genomic DNA. Translation: AAO70019.1.
RefSeqiNP_455028.1. NC_003198.1.
NP_806159.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO70019; AAO70019; t2430.
CAD08890; CAD08890; CAD08890.
GeneIDi1246947.
KEGGisty:STY0473.
PATRICi18538780. VBISalEnt120419_0474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD08890.1 .
AE014613 Genomic DNA. Translation: AAO70019.1 .
RefSeqi NP_455028.1. NC_003198.1.
NP_806159.1. NC_004631.1.

3D structure databases

ProteinModelPortali Q8Z8W3.
SMRi Q8Z8W3. Positions 1-293.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220341.STY0473.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO70019 ; AAO70019 ; t2430 .
CAD08890 ; CAD08890 ; CAD08890 .
GeneIDi 1246947.
KEGGi sty:STY0473.
PATRICi 18538780. VBISalEnt120419_0474.

Phylogenomic databases

eggNOGi COG1893.
HOGENOMi HOG000050223.
KOi K00077.
OMAi IEFINGW.
OrthoDBi EOG68SVW3.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00004 .

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiPANE_SALTI
AccessioniPrimary (citable) accession number: Q8Z8W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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