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Protein

2-dehydropantoate 2-reductase

Gene

panE

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 3-methyl-2-oxobutanoate hydroxymethyltransferase (panB)
  2. 2-dehydropantoate 2-reductase (STY2819), 2-dehydropantoate 2-reductase (panE)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei31NADP; via amide nitrogenBy similarity1
Binding sitei98NADP; via amide nitrogenBy similarity1
Binding sitei98SubstrateBy similarity1
Binding sitei122NADP; via amide nitrogen and carbonyl oxygenBy similarity1
Active sitei176Proton donor1
Binding sitei180SubstrateBy similarity1
Binding sitei184SubstrateBy similarity1
Binding sitei194SubstrateBy similarity1
Binding sitei241SubstrateBy similarity1
Binding sitei244SubstrateBy similarity1
Binding sitei256NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 12NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPantothenate biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Name:panE
Synonyms:apbA
Ordered Locus Names:STY0473, t2430
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001573031 – 3032-dehydropantoate 2-reductaseAdd BLAST303

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi220341.STY0473

Structurei

3D structure databases

ProteinModelPortaliQ8Z8W3
SMRiQ8Z8W3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiENOG4108JZF Bacteria
COG1893 LUCA
HOGENOMiHOG000050223
KOiK00077
OMAiLTVLHDC

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR003710 ApbA
IPR013752 KPA_reductase
IPR013332 KPR_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02558 ApbA, 1 hit
PF08546 ApbA_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00745 apbA_panE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Z8W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITVLGCGA LGQLWLSALC KHGHDVQGWL RVPQPYCSVN LIDTDGSFFN
60 70 80 90 100
ESLTANDPDF LAKSELLLVT LKAWQVSDAV RTLASTLPVT SPILLIHNGM
110 120 130 140 150
GTIEELQSIQ QPMLMGAITH AARRDGNIII HVANGTTHIG PAREQDGDYS
160 170 180 190 200
YLAEILQGVL PDVAWHNNIR AEMWRKLAVN CVINPLTALW NCPNGELRHH
210 220 230 240 250
TDEINAICEE VAAVIEREGY HTSADDLCYY VEQVIDSTAE NISSMLQDVR
260 270 280 290 300
AMRHTEIDYI TGYLLKRARV HGLAVPENSR LFEMVKRKES EYERSGTGMP

RPW
Length:303
Mass (Da):33,842
Last modified:February 21, 2002 - v1
Checksum:i0369C148A42BF583
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117A → T in AAO70019 (PubMed:12644504).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD08890.1
AE014613 Genomic DNA Translation: AAO70019.1
RefSeqiNP_455028.1, NC_003198.1
WP_000705818.1, NZ_CVPK01000026.1

Genome annotation databases

EnsemblBacteriaiAAO70019; AAO70019; t2430
CAD08890; CAD08890; CAD08890
GeneIDi1246947
KEGGistt:t2430
sty:STY0473
PATRICifig|220341.7.peg.474

Similar proteinsi

Entry informationi

Entry nameiPANE_SALTI
AccessioniPrimary (citable) accession number: Q8Z8W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health