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Protein

Acetyl esterase

Gene

aes

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei165UniRule annotation1
Active sitei262UniRule annotation1
Active sitei292UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Serine esterase

Protein family/group databases

ESTHERisalty-AES Hormone-sensitive_lipase_like

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl esteraseUniRule annotation (EC:3.1.1.-UniRule annotation)
Gene namesi
Name:aesUniRule annotation
Ordered Locus Names:STY0534, t2370
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397101 – 323Acetyl esteraseAdd BLAST323

Interactioni

Subunit structurei

Homodimer. Interacts with MalT and MelA.UniRule annotation

Protein-protein interaction databases

STRINGi220341.STY0534

Structurei

3D structure databases

ProteinModelPortaliQ8Z8T1
SMRiQ8Z8T1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi91 – 93Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity3

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F2M Bacteria
COG0657 LUCA
HOGENOMiHOG000117644
KOiK01066
OMAiGIIGMNS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
HAMAPiMF_01958 Acetyl_esterase, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013094 AB_hydrolase_3
IPR023508 Acetyl_esterase
IPR033140 Lipase_GDXG_put_SER_AS
PfamiView protein in Pfam
PF07859 Abhydrolase_3, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS01174 LIPASE_GDXG_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Z8T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPENKIPVL TRLSDEMTAV VNFQQPGLPP WPADGDIETQ RQYYLLERRF
60 70 80 90 100
WNADAPSMTT RTCAVSTPYG DVTTRLYSPQ PTSQATLYYL HGGGFILGNL
110 120 130 140 150
DTHDRIMRLL ARYTGCTVIG IDYSLSPQAR YPQAIEETVA VCSYFSQHAD
160 170 180 190 200
EYSLNVEEIG FAGDSAGAML ALASALWLRD KHIRCGNVIA ILLWYGLYGL
210 220 230 240 250
QDSVSRRLFG GAWDGLTRED LDMYEKAYLR NDEDRESPWY CLFNNDLTRD
260 270 280 290 300
VPPCFIASAE FDPLIDDSRL LHQTLQAHQQ PCEYKMYPGT LHAFLHYSRM
310 320
MTIADDALQD GARFFMARMK TPR
Length:323
Mass (Da):36,790
Last modified:March 1, 2002 - v1
Checksum:iE0BFCF7271781C71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD04975.1
AE014613 Genomic DNA Translation: AAO69961.1
RefSeqiNP_455086.1, NC_003198.1
WP_000801788.1, NZ_PHKG01000010.1

Genome annotation databases

EnsemblBacteriaiAAO69961; AAO69961; t2370
CAD04975; CAD04975; CAD04975
GeneIDi1247007
KEGGistt:t2370
sty:STY0534
PATRICifig|220341.7.peg.537

Similar proteinsi

Entry informationi

Entry nameiAES_SALTI
AccessioniPrimary (citable) accession number: Q8Z8T1
Secondary accession number(s): Q7C8B2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health