Reviewed, UniProtKB/Swiss-Prot Q8Z8S4 (COPA_SALTI)

Names and origin

Protein names

Recommended name:
    Copper-exporting P-type ATPase A
    EC=3.6.3.n1

Gene names

Name:	copA
Ordered Locus Names:	STY0544, t2362

Organism

Salmonella typhi [Complete proteome] [HAMAP]

Taxonomic identifier

90370 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	833 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in copper export By similarity.
Catalytic activity	ATP + H2O + Cu1+(In) = ADP + phosphate + Cu1+(Out).
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IB subfamily. Contains 2 HMA domains.

Ontologies

Keywords
Biological process	Copper transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Copper Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro copper ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW copper-exporting ATPase activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 833	832	Copper-exporting P-type ATPase A		PRO_0000046322
Regions
	Transmembrane	186 – 206	21	Potential
	Transmembrane	217 – 237	21	Potential
	Transmembrane	253 – 273	21	Potential
	Transmembrane	283 – 303	21	Potential
	Transmembrane	437 – 457	21	Potential
	Transmembrane	463 – 483	21	Potential
	Transmembrane	778 – 798	21	Potential
	Transmembrane	800 – 820	21	Potential
	Domain	4 – 65	62	HMA 1
	Domain	99 – 162	64	HMA 2
Sites
	Active site	522	1	4-aspartylphosphate intermediate Probable
	Metal binding	14	1	Copper Potential
	Metal binding	17	1	Copper Potential
	Metal binding	109	1	Copper Potential
	Metal binding	112	1	Copper Potential
	Metal binding	719	1	Magnesium By similarity
	Metal binding	723	1	Magnesium By similarity
Experimental info
	Sequence conflict	290	1	M → V in AAO69954. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8Z8S4-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 350813001A756871	FASTA	833	87,838
	10 20 30 40 50 60 MSQTIDLTLD GLSCGHCVKR VKESLEQRPD VELADVTVTE AHVTGTASAD ALIETIKQAG 70 80 90 100 110 120 YGATLSHPKA KPLTESSIPS EALAAVPHEL PVATADEESQ QLLLSGMSCA SCVTRVQHAL 130 140 150 160 170 180 QSVPGVTQAR VNLAERTALV MGSASAADLV QAVEKAGYGA EAIEDDIKRR ERQQETAIAT 190 200 210 220 230 240 MKRFRWQAIV ALAVGIPVMV WGMIGDNMMV TGDNRSLWLA IGLITLAVMV FAGGHFYRNA 250 260 270 280 290 300 WKSLLNGTAT MDTLVALGTG VAWLYSMSVN LWPQWFPMEA RHLYYEASAM IIGLINLGHM 310 320 330 340 350 360 LEARARQRSS KALEKLLDLT PPTARVVTED GEKSVPLADV QPGMLLRLTT GDRVPVDGEI 370 380 390 400 410 420 TQGEAWLDEA MLTGEPIPQQ KGEGDSVHAG TVVQDGSILF RASAVGSHTT LSRIIRMVRQ 430 440 450 460 470 480 AQSSKPEIGQ LADKISAVFV PVVVAIALFS AAIWYFFGPA PQIVYTLVIA TTVLIIACPC 490 500 510 520 530 540 ALGLATPMSI ISGVGRAAEF GVLVRDADAL QRASTLDTLV FDKTGTLTEG KPQVVAVKTF 550 560 570 580 590 600 NGVDEAQALR LAAALEQGSS HPLAHAILEK AGDDKLPQVN GFRTLRGLGV SGEAEGHQLL 610 620 630 640 650 660 LGNQALLNEQ HVATDDMTAE ITAQASQGST PVLLAIDGKA AALLAVRDPL RSDSIAALER 670 680 690 700 710 720 LHNAGYRLVM LTGDNPTTAN AIAKEAGIDE VIAGVLPDGK ADAIKRLQSQ GRQVAMVGDG 730 740 750 760 770 780 INDAPALAQA DVGIAMGGGS DVAIETAAIT LMRHSLMGVA DALAISRATL RNMKQNLLGA 790 800 810 820 830 FIYNSIGIPV AAGILWPFTG TLLNPVVAGA AMALSSITVV SNANRLLRFK PKA

References

[1]

"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18." Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. , Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:848-852(2001) [PubMed: 11677608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT18.

[2]

"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18." Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R. J. Bacteriol. 185:2330-2337(2003) [PubMed: 12644504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700931 / Ty2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL627267 Genomic DNA. Translation: CAD04983.1. AE014613 Genomic DNA. Translation: AAO69954.1.
RefSeq	NP_455093.1. NP_806094.1.
3D structure databases
HSSP	HSSP built from PDB template 1K0V based on UniProtKB O32221.
ModBase	Search...
Genome annotation databases
GeneID	1067370. 1247015.
GenomeReviews	Gene locus t2362 in contig AE014613_GR. Gene locus STY0544 in contig AL513382_GR.
KEGG	stt:t2362. sty:STY0544.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8Z8S4.
OMA	Q8Z8S4. SCVSRVQ.
Enzyme and pathway databases
BioCyc	SENT209261:T2362-MON. SENT220341:STY0544-MON.
BRENDA	3.6.3.4. 3716.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR006403. ATPase_P-typ_cat/Cu-transptr. IPR000695. ATPase_P-typ_H-transp. IPR006416. ATPase_P-typ_heavy-metal. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_phosphor_site. IPR005834. Dehalogen-like_hydro. IPR017969. Heavy-metal-associated_CS. IPR006121. HeavyMe_transpt. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00403. HMA. 2 hits. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
TIGRFAMs	TIGR01511. ATPase-IB1_Cu. 1 hit. TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. PS01047. HMA_1. 2 hits. PS50846. HMA_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COPA_SALTI

Accession

Primary (citable) accession number: Q8Z8S4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2002
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 64 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)