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Protein

HTH-type transcriptional regulator CueR

Gene

cueR

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi112Copper(1+)By similarity1
Metal bindingi120Copper(1+)By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi4 – 23H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator CueR
Alternative name(s):
Copper efflux regulator
Copper export regulator
Gene namesi
Name:cueR
Ordered Locus Names:STY0545, t2361
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981141 – 138HTH-type transcriptional regulator CueRAdd BLAST138

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi220341.STY0545

Structurei

3D structure databases

ProteinModelPortaliQ8Z8S3
SMRiQ8Z8S3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 69HTH merR-typePROSITE-ProRule annotationAdd BLAST69

Domaini

It contains a N-terminal DNA binding region and a C-terminal metal binding region.By similarity

Phylogenomic databases

eggNOGiENOG4108Z6Z Bacteria
COG0789 LUCA
HOGENOMiHOG000266076
KOiK19591
OMAiYDERAVH

Family and domain databases

CDDicd01108 HTH_CueR, 1 hit
InterProiView protein in InterPro
IPR011789 CueR
IPR009061 DNA-bd_dom_put_sf
IPR000551 MerR-type_HTH_dom
PfamiView protein in Pfam
PF13411 MerR_1, 1 hit
PRINTSiPR00040 HTHMERR
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
TIGRFAMsiTIGR02044 CueR, 1 hit
PROSITEiView protein in PROSITE
PS00552 HTH_MERR_1, 1 hit
PS50937 HTH_MERR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Z8S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNISDVAKKT GLTSKAIRFY EEKGLVTPPL RSENGYRTYT QKHLNELTLL
60 70 80 90 100
RQARQVGFNL EECGELVNLF NDPRRHSADV KKRTLEKVAE IERHISELQS
110 120 130
MRDQLLAMAE SCPGDDSADC PIIDNLSGCC HHKAQKLR
Length:138
Mass (Da):15,682
Last modified:March 1, 2002 - v1
Checksum:i3A7691C23EA6D940
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD04984.1
AE014613 Genomic DNA Translation: AAO69953.1
RefSeqiNP_455094.1, NC_003198.1
WP_001026762.1, NZ_PHKG01000010.1

Genome annotation databases

EnsemblBacteriaiAAO69953; AAO69953; t2361
CAD04984; CAD04984; CAD04984
GeneIDi1247016
KEGGistt:t2361
sty:STY0545
PATRICifig|220341.7.peg.548

Similar proteinsi

Entry informationi

Entry nameiCUER_SALTI
AccessioniPrimary (citable) accession number: Q8Z8S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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