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Protein

Cardiolipin synthase B

Gene

clsB

Organism
Salmonella typhi
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei113 – 1131UniRule annotation
Active sitei115 – 1151UniRule annotation
Active sitei120 – 1201UniRule annotation
Active sitei290 – 2901UniRule annotation
Active sitei292 – 2921UniRule annotation
Active sitei297 – 2971UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase BUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsBUniRule annotation
Synonyms:ybhO
Ordered Locus Names:STY0847, t2076
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Cardiolipin synthase BPRO_0000201286Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220341.STY0847.

Structurei

3D structure databases

ProteinModelPortaliQ8Z883.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 13528PLD phosphodiesterase 1UniRule annotationAdd
BLAST
Domaini285 – 31228PLD phosphodiesterase 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsB sub-subfamily.UniRule annotation
Contains 2 PLD phosphodiesterase domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DZQ. Bacteria.
COG1502. LUCA.
HOGENOMiHOG000264393.
KOiK06131.
OMAiTHRKILI.
OrthoDBiEOG6Q2ST0.

Family and domain databases

HAMAPiMF_01917. Cardiolipin_synth_ClsB.
InterProiIPR030872. Cardiolipin_synth_ClsB.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8Z883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCGWREGNQ IQLLENGDQF YPAVFEAIAQ AQQKIILETF ILFEDEVGKK
60 70 80 90 100
LHAALLKAAQ RGVKAEVLLD GYGSPDLSDA FVGELTSAGV IFRYYDPRPR
110 120 130 140 150
LLGLRTNIFR RMHRKIVVID DRIAFVGGIN YSAEHMSDYG PQAKQDYAVR
160 170 180 190 200
VEGPVVADIL QFEVENLPGQ SPARRWWKRH HQAEENRHPG EAQALFVWRD
210 220 230 240 250
NEEHRDDIER HYLKMLTQAK REVIIANAYF FPGYRLLHAM RKAARRGVSV
260 270 280 290 300
KLIVQGEPDM PIVKVGARLL YNYLVKGGVQ VYEYRRRPLH GKVALMDDHW
310 320 330 340 350
ATVGSSNLDP LSLSLNLEAN LIIHDRTFNQ TLRDNLQGII VNDCKQVDES
360 370 380 390 400
MLPKRTWWNL TKSVLAFHFL RHFPALVGWL PAHTPHLAQV PPPAQPEMET
410
QDRVDPENSG VKP
Length:413
Mass (Da):47,258
Last modified:March 1, 2002 - v1
Checksum:i1F71EEFD90CCF463
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD05259.1.
AE014613 Genomic DNA. Translation: AAO69696.1.
RefSeqiNP_455350.1. NC_003198.1.
WP_000649638.1. NZ_FFOG01000008.1.

Genome annotation databases

EnsemblBacteriaiAAO69696; AAO69696; t2076.
CAD05259; CAD05259; CAD05259.
GeneIDi1247291.
KEGGistt:t2076.
sty:STY0847.
PATRICi18539563. VBISalEnt120419_0852.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD05259.1.
AE014613 Genomic DNA. Translation: AAO69696.1.
RefSeqiNP_455350.1. NC_003198.1.
WP_000649638.1. NZ_FFOG01000008.1.

3D structure databases

ProteinModelPortaliQ8Z883.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220341.STY0847.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO69696; AAO69696; t2076.
CAD05259; CAD05259; CAD05259.
GeneIDi1247291.
KEGGistt:t2076.
sty:STY0847.
PATRICi18539563. VBISalEnt120419_0852.

Phylogenomic databases

eggNOGiENOG4105DZQ. Bacteria.
COG1502. LUCA.
HOGENOMiHOG000264393.
KOiK06131.
OMAiTHRKILI.
OrthoDBiEOG6Q2ST0.

Family and domain databases

HAMAPiMF_01917. Cardiolipin_synth_ClsB.
InterProiIPR030872. Cardiolipin_synth_ClsB.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiCLSB_SALTI
AccessioniPrimary (citable) accession number: Q8Z883
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.