Q8Z7Y9PNCB_SALTINicotinate phosphoribosyltransferaseNAPRTase6.3.4.21pncBSTY1010t1930Salmonella typhiBacteriaPseudomonadotaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonellaComplete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphateCofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.Belongs to the NAPRTase family.LigasePhosphoproteinPyridine nucleotide biosynthesisMTQFASPVLHSLLDTDAYKLHMQQAVFHHYYDVQVAAEFRCRGDDLLGIYADAIREQVDAMQHLRLQEDEFQWLSGLPFFKPDYLNWLREFRYNPAQVCVTNDNGKLNIRLTGSWREVIMWEVPLLAVISELVHHYRSPNAGVDQALDALESKLVDFTALTANLDMSRFHLMDFGTRRRFSREVQQAIVKRLQQESWFVGTSNYDLARRLALTPMGTQAHEWFQAHQQINPDLATSQRAALAAWLNEYPDQLGIALTDCITMDAFLRDFGIEFASRYQGLRHDSGDPVAWGEKAIAHYEKLGIDPLTKTLVFSDNLDLPKAVELYRHFASRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLPQVRKAS
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