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Protein

Site-specific DNA-methyltransferase (adenine-specific)

Gene

dam_2

Organism
Salmonella typhi
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301S-adenosyl-L-methionineUniRule annotation
Binding sitei34 – 341S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
Binding sitei75 – 751S-adenosyl-L-methionineUniRule annotation
Binding sitei202 – 2021S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationImported, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Protein family/group databases

REBASEi5682. M.StyCORF1014P.

Names & Taxonomyi

Protein namesi
Recommended name:
Site-specific DNA-methyltransferase (adenine-specific)UniRule annotation (EC:2.1.1.72UniRule annotation)
Gene namesi
Name:dam_2Imported
Synonyms:dam_5Imported
Ordered Locus Names:STY1014Imported, t1926Imported
ORF Names:ACT03_05255Imported, ACT04_10425Imported, ERS083263_01574Imported, ERS325172_01727Imported, ERS325188_01735Imported, ERS325190_02122Imported, ERS325196_03093Imported, ERS325215_01734Imported, ERS325223_01737Imported, ERS325225_04264Imported, ERS325232_01740Imported, ERS325296_01780Imported, ERS325302_01471Imported, ERS325320_03189Imported, ERS325374_01969Imported, ERS325389_01714Imported, ERS325400_01825Imported, ERS325434_03054Imported, ERS325436_01737Imported, ERS325437_01812Imported, ERS325458_01828Imported, ERS326267_01597Imported, ERS326384_01645Imported, ERS326389_01813Imported, ERS326420_01854Imported, ERS326462_01993Imported, ERS326499_03283Imported, ERS327392_02199Imported
OrganismiSalmonella typhiImported
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000002670 Componenti: Chromosome UP000000541 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi220341.STY1014.

Family & Domainsi

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0338. LUCA.
ENOG4105DFE. Bacteria.
HOGENOMiHOG000281348.
KOiK06223.
OMAiWRRPFLK.
OrthoDBiEOG6CS08V.

Family and domain databases

Gene3Di1.10.1020.10. 1 hit.
3.40.50.150. 2 hits.
InterProiIPR023095. Ade_MeTrfase_dom_2.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012263. M_m6A_EcoRV.
IPR012327. MeTrfase_D12.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF02086. MethyltransfD12. 1 hit.
[Graphical view]
PIRSFiPIRSF000398. M_m6A_EcoRV. 1 hit.
PRINTSiPR00505. D12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00571. dam. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8Z7Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYGSVCSGT AAMPIEEPAL RTWRRPFLKW AGGKYSLLPE LDRLIPAGKR
60 70 80 90 100
LIEPFVGGGS VFLNSDKHER FLLADVNADL INLYQMLAVV PDSVIAEAMK
110 120 130 140 150
AFRHLNDAEN YTVIREAFNA QKLNATERAA AFLYLNRHCF NGLMRYNLDG
160 170 180 190 200
FFNVGWGKYK APYFPEEEIR AFRQKSHACV FMTAGFERTL RLAGDGDVVY
210 220 230 240 250
CDPPYEPMPG TAGFTNYASG GFSWDSQVAL AESCVAAHQR GAKVFISNST
260 270 280 290
APRVIELYER HGFTLHRVNA RRSISSKGST RETANDIVAS LGI
Length:293
Mass (Da):32,664
Last modified:March 1, 2002 - v1
Checksum:i480554FEC8EFD1F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014613 Genomic DNA. Translation: AAO69542.1.
CP012091 Genomic DNA. Translation: ALG16670.1.
CP012151 Genomic DNA. Translation: ALG22008.1.
AL513382 Genomic DNA. Translation: CAD05408.1.
CEXJ01000006 Genomic DNA. Translation: CER22764.1.
CEXP01000007 Genomic DNA. Translation: CER51026.1.
CEXU01000008 Genomic DNA. Translation: CER73550.1.
CEYE01000006 Genomic DNA. Translation: CES13830.1.
CEYF01000007 Genomic DNA. Translation: CES19011.1.
CEYH01000006 Genomic DNA. Translation: CES33041.1.
CEYU01000007 Genomic DNA. Translation: CES88195.1.
CEZA01000006 Genomic DNA. Translation: CET17077.1.
CUYQ01000005 Genomic DNA. Translation: CQS58146.1.
CUZH01000006 Genomic DNA. Translation: CQS68963.1.
CUYW01000006 Genomic DNA. Translation: CQS72396.1.
CUYO01000007 Genomic DNA. Translation: CQS73717.1.
CUZV01000006 Genomic DNA. Translation: CQS74859.1.
CUZM01000007 Genomic DNA. Translation: CQS74895.1.
CUYZ01000007 Genomic DNA. Translation: CQS85614.1.
CUYV01000015 Genomic DNA. Translation: CQT40569.1.
CUZW01000015 Genomic DNA. Translation: CQT43303.1.
CUYJ01000029 Genomic DNA. Translation: CQT88402.1.
CVAI01000006 Genomic DNA. Translation: CQU77411.1.
CVBK01000006 Genomic DNA. Translation: CQV09135.1.
CVCK01000006 Genomic DNA. Translation: CQW82888.1.
CVCL01000007 Genomic DNA. Translation: CQW87452.1.
CVCJ01000014 Genomic DNA. Translation: CQX42896.1.
CVCV01000007 Genomic DNA. Translation: CQX47837.1.
CVFY01000006 Genomic DNA. Translation: CRB11694.1.
CVGS01000015 Genomic DNA. Translation: CRC89660.1.
RefSeqiNP_455493.1. NC_003198.1.
WP_010989138.1. NZ_CXZB01000007.1.

Genome annotation databases

EnsemblBacteriaiCAD05408; CAD05408; CAD05408.
CEP52580; CEP52580; ERS325052_01668.
CEQ60821; CEQ60821; ERS326331_01987.
CER12703; CER12703; ERS248971_01801.
CER18501; CER18501; ERS326259_01986.
CER22764; CER22764; ERS325172_01727.
CER27458; CER27458; ERS326407_01673.
CER46033; CER46033; ERS326268_01945.
CER51026; CER51026; ERS326420_01854.
CER52493; CER52493; ERS325165_01380.
CER61448; CER61448; ERS325101_01732.
CER63361; CER63361; ERS326475_01943.
CER64770; CER64770; ERS326373_02375.
CES03868; CES03868; ERS326249_01629.
CES10604; CES10604; ERS326256_01991.
CES13830; CES13830; ERS326384_01645.
CES19011; CES19011; ERS326389_01813.
CES33041; CES33041; ERS326267_01597.
CES88195; CES88195; ERS326462_01993.
CET03529; CET03529; ERS326456_01784.
CET17077; CET17077; ERS083263_01574.
CET25096; CET25096; ERS326469_01694.
CET76818; CET76818; ERS326314_01988.
CET79955; CET79955; ERS326412_01598.
CET89897; CET89897; ERS326275_01943.
CEU06562; CEU06562; ERS326422_01924.
GeneIDi1247440.
KEGGistt:t1926.
sty:STY1014.
PATRICi18539910. VBISalEnt120419_1023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014613 Genomic DNA. Translation: AAO69542.1.
CP012091 Genomic DNA. Translation: ALG16670.1.
CP012151 Genomic DNA. Translation: ALG22008.1.
AL513382 Genomic DNA. Translation: CAD05408.1.
CEXJ01000006 Genomic DNA. Translation: CER22764.1.
CEXP01000007 Genomic DNA. Translation: CER51026.1.
CEXU01000008 Genomic DNA. Translation: CER73550.1.
CEYE01000006 Genomic DNA. Translation: CES13830.1.
CEYF01000007 Genomic DNA. Translation: CES19011.1.
CEYH01000006 Genomic DNA. Translation: CES33041.1.
CEYU01000007 Genomic DNA. Translation: CES88195.1.
CEZA01000006 Genomic DNA. Translation: CET17077.1.
CUYQ01000005 Genomic DNA. Translation: CQS58146.1.
CUZH01000006 Genomic DNA. Translation: CQS68963.1.
CUYW01000006 Genomic DNA. Translation: CQS72396.1.
CUYO01000007 Genomic DNA. Translation: CQS73717.1.
CUZV01000006 Genomic DNA. Translation: CQS74859.1.
CUZM01000007 Genomic DNA. Translation: CQS74895.1.
CUYZ01000007 Genomic DNA. Translation: CQS85614.1.
CUYV01000015 Genomic DNA. Translation: CQT40569.1.
CUZW01000015 Genomic DNA. Translation: CQT43303.1.
CUYJ01000029 Genomic DNA. Translation: CQT88402.1.
CVAI01000006 Genomic DNA. Translation: CQU77411.1.
CVBK01000006 Genomic DNA. Translation: CQV09135.1.
CVCK01000006 Genomic DNA. Translation: CQW82888.1.
CVCL01000007 Genomic DNA. Translation: CQW87452.1.
CVCJ01000014 Genomic DNA. Translation: CQX42896.1.
CVCV01000007 Genomic DNA. Translation: CQX47837.1.
CVFY01000006 Genomic DNA. Translation: CRB11694.1.
CVGS01000015 Genomic DNA. Translation: CRC89660.1.
RefSeqiNP_455493.1. NC_003198.1.
WP_010989138.1. NZ_CXZB01000007.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220341.STY1014.

Protein family/group databases

REBASEi5682. M.StyCORF1014P.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD05408; CAD05408; CAD05408.
CEP52580; CEP52580; ERS325052_01668.
CEQ60821; CEQ60821; ERS326331_01987.
CER12703; CER12703; ERS248971_01801.
CER18501; CER18501; ERS326259_01986.
CER22764; CER22764; ERS325172_01727.
CER27458; CER27458; ERS326407_01673.
CER46033; CER46033; ERS326268_01945.
CER51026; CER51026; ERS326420_01854.
CER52493; CER52493; ERS325165_01380.
CER61448; CER61448; ERS325101_01732.
CER63361; CER63361; ERS326475_01943.
CER64770; CER64770; ERS326373_02375.
CES03868; CES03868; ERS326249_01629.
CES10604; CES10604; ERS326256_01991.
CES13830; CES13830; ERS326384_01645.
CES19011; CES19011; ERS326389_01813.
CES33041; CES33041; ERS326267_01597.
CES88195; CES88195; ERS326462_01993.
CET03529; CET03529; ERS326456_01784.
CET17077; CET17077; ERS083263_01574.
CET25096; CET25096; ERS326469_01694.
CET76818; CET76818; ERS326314_01988.
CET79955; CET79955; ERS326412_01598.
CET89897; CET89897; ERS326275_01943.
CEU06562; CEU06562; ERS326422_01924.
GeneIDi1247440.
KEGGistt:t1926.
sty:STY1014.
PATRICi18539910. VBISalEnt120419_1023.

Phylogenomic databases

eggNOGiCOG0338. LUCA.
ENOG4105DFE. Bacteria.
HOGENOMiHOG000281348.
KOiK06223.
OMAiWRRPFLK.
OrthoDBiEOG6CS08V.

Family and domain databases

Gene3Di1.10.1020.10. 1 hit.
3.40.50.150. 2 hits.
InterProiIPR023095. Ade_MeTrfase_dom_2.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012263. M_m6A_EcoRV.
IPR012327. MeTrfase_D12.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF02086. MethyltransfD12. 1 hit.
[Graphical view]
PIRSFiPIRSF000398. M_m6A_EcoRV. 1 hit.
PRINTSiPR00505. D12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00571. dam. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18Imported.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2Imported and Ty2Imported.
  3. Informatics Pathogen
    Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A59307Imported, Dn136Imported, Dn160Imported, Dn189Imported, Dn45Imported, Dtc103Imported, Dtc81Imported, Dtc98Imported, IB5341Imported, Ipt57Imported, MDUST167Imported, MDUST284Imported, MDUST289Imported, MDUST320Imported, MDUST362Imported, MDUST399Imported, Np93Imported, Ty1-16Imported, Ty2-101Imported, Ty2-107Imported, Ty2-115Imported, Ty2-120Imported, Ty2-170Imported, Ty2-71Imported, Ty2-75Imported and Ty3-193Imported.
  4. "Complete Genome Sequence of Salmonella enterica sibsp. enterica serovar Typhi Isolate B/SF/13/03/195 Associated with a Typhoid Carrier in Pasir Mas, Kelantan, Malaysia."
    Muhamad Harish S., Sim K.S., Mohd Nor F., Mat Hussin H., Hamzah W.M., Mohd Najimuddin M.N., Ismail A.
    Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B/SF/13/03/195Imported.
  5. "Genome Sequence of Salmonella enterica subsp. enterica serovar Typhi Isolate PM016/13 from Well Water Associated with a Typhoid Outbreak in Pasir Mas, Kelantan, Malaysia."
    Ismail A., Muhamad Harish S., Sim K.S., Mohd Najimuddin M.N.
    Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PM016/13Imported.

Entry informationi

Entry nameiQ8Z7Y6_SALTI
AccessioniPrimary (citable) accession number: Q8Z7Y6
Secondary accession number(s): A0A0C8U8F1, A0A0C9FHS5, Q7C900
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: January 20, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.