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Protein

Inositol phosphate phosphatase SopB

Gene

sopB

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei460Curated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processVirulence

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol phosphate phosphatase SopB (EC:3.1.3.-)
Alternative name(s):
Effector protein SopB
Gene namesi
Name:sopB
Synonyms:sigD
Ordered Locus Names:STY1121, t1828
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

  • Secreted By similarity
  • Note: Secreted via the type III secretion system 1 (SPI-1 TTSS).By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002204941 – 561Inositol phosphate phosphatase SopBAdd BLAST561

Interactioni

Protein-protein interaction databases

STRINGi220341.STY1121

Structurei

3D structure databases

SMRiQ8Z7R1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi460 – 466CX5R motif7

Domaini

Contains the consensus sequence Cys-X(5)-Arg characteristic of Mg-independent phosphatases.By similarity

Sequence similaritiesi

Belongs to the phosphatase IpgD/SopB family.Curated

Phylogenomic databases

eggNOGiENOG4108N4M Bacteria
ENOG410Y7WM LUCA
HOGENOMiHOG000028303
KOiK13085
OMAiCWNCKSG

Family and domain databases

InterProiView protein in InterPro
IPR008108 IpgD/SopB
PfamiView protein in Pfam
PF05925 IpgD, 1 hit
PRINTSiPR01734 TYPE3OMBPROT

Sequencei

Sequence statusi: Complete.

Q8Z7R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIQSFYHSA SLKTQEAFKS LQKTLYNGMQ ILSGQGKAPA KAPDARPEII
60 70 80 90 100
VLREPGATWG NYLQHQKTSN HSLHNLYNLQ RDLLTVAATV LGKQDPVLTS
110 120 130 140 150
MANQMELAKV KADRPATKQE EAAAKALKKN LIELIAARTQ QQNGLPAKEA
160 170 180 190 200
HRFAAVAFRD AQVKQLNNQP WQTIKNTLTH NGHHYTNTQL PAAEMKIGAK
210 220 230 240 250
DIFPSAYEGK GVCSWDTKNI HHANNLWMST VSVHEDGKDK TLFCGIRHGV
260 270 280 290 300
LSPYHEKDPL LRQAGAENKA KEVLAAALFS KPELLNRALE GEAVSLKLVS
310 320 330 340 350
VGLLTASNIF GKEGTMVEDQ MRAWQSLTQP GKMIHLKIRN KDGDLQTVKI
360 370 380 390 400
KPDVAAFNVG VNELALKLGF GLKASDSYNA EALHQLLGND LRPEARPGGW
410 420 430 440 450
VGEWLAQYPD NYEVVNTLAR QIKDIWKNNQ HHKDGGEPYK LAQRLAMLAH
460 470 480 490 500
EIDAVPAWNC KSGKDRTGMM DSEIKRELIS FHQTHMLSAP GSLPDSGGQK
510 520 530 540 550
IFQKVLLNSG NLEIQKQNTG GAGNKVMKNL SPEVLNLSYQ KRVGDENIWQ
560
SVKGISSLIT S
Length:561
Mass (Da):62,017
Last modified:March 1, 2002 - v1
Checksum:i774057AE49A0BF2D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti528K → H in AAF21055 (PubMed:11200542).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD08217.1
AE014613 Genomic DNA Translation: AAO69449.1
AF213333 Genomic DNA Translation: AAF21055.1
RefSeqiNP_455588.1, NC_003198.1
WP_001166955.1, NZ_PHKG01000019.1

Genome annotation databases

EnsemblBacteriaiAAO69449; AAO69449; t1828
CAD08217; CAD08217; CAD08217
GeneIDi1247536
KEGGistt:t1828
sty:STY1121
PATRICifig|220341.7.peg.1124

Similar proteinsi

Entry informationi

Entry nameiSOPB_SALTI
AccessioniPrimary (citable) accession number: Q8Z7R1
Secondary accession number(s): Q7C973, Q9RER3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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