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Protein

Inositol phosphate phosphatase SopB

Gene

sopB

Organism
Salmonella typhi
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei460 – 4601Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol phosphate phosphatase SopB (EC:3.1.3.-)
Alternative name(s):
Effector protein SopB
Gene namesi
Name:sopB
Synonyms:sigD
Ordered Locus Names:STY1121, t1828
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

  • Secreted By similarity

  • Note: Secreted via the type III secretion system 1 (SPI-1 TTSS).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Inositol phosphate phosphatase SopBPRO_0000220494Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220341.STY1121.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi460 – 4667CX5R motif

Domaini

Contains the consensus sequence Cys-X(5)-Arg characteristic of Mg-independent phosphatases.By similarity

Sequence similaritiesi

Belongs to the phosphatase IpgD/SopB family.Curated

Phylogenomic databases

eggNOGiENOG4108N4M. Bacteria.
ENOG410Y7WM. LUCA.
HOGENOMiHOG000028303.
KOiK13085.
OMAiCWNCKSG.

Family and domain databases

InterProiIPR008108. IpgD/SopB.
[Graphical view]
PfamiPF05925. IpgD. 1 hit.
[Graphical view]
PRINTSiPR01734. TYPE3OMBPROT.

Sequencei

Sequence statusi: Complete.

Q8Z7R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIQSFYHSA SLKTQEAFKS LQKTLYNGMQ ILSGQGKAPA KAPDARPEII
60 70 80 90 100
VLREPGATWG NYLQHQKTSN HSLHNLYNLQ RDLLTVAATV LGKQDPVLTS
110 120 130 140 150
MANQMELAKV KADRPATKQE EAAAKALKKN LIELIAARTQ QQNGLPAKEA
160 170 180 190 200
HRFAAVAFRD AQVKQLNNQP WQTIKNTLTH NGHHYTNTQL PAAEMKIGAK
210 220 230 240 250
DIFPSAYEGK GVCSWDTKNI HHANNLWMST VSVHEDGKDK TLFCGIRHGV
260 270 280 290 300
LSPYHEKDPL LRQAGAENKA KEVLAAALFS KPELLNRALE GEAVSLKLVS
310 320 330 340 350
VGLLTASNIF GKEGTMVEDQ MRAWQSLTQP GKMIHLKIRN KDGDLQTVKI
360 370 380 390 400
KPDVAAFNVG VNELALKLGF GLKASDSYNA EALHQLLGND LRPEARPGGW
410 420 430 440 450
VGEWLAQYPD NYEVVNTLAR QIKDIWKNNQ HHKDGGEPYK LAQRLAMLAH
460 470 480 490 500
EIDAVPAWNC KSGKDRTGMM DSEIKRELIS FHQTHMLSAP GSLPDSGGQK
510 520 530 540 550
IFQKVLLNSG NLEIQKQNTG GAGNKVMKNL SPEVLNLSYQ KRVGDENIWQ
560
SVKGISSLIT S
Length:561
Mass (Da):62,017
Last modified:March 1, 2002 - v1
Checksum:i774057AE49A0BF2D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti528 – 5281K → H in AAF21055 (PubMed:11200542).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD08217.1.
AE014613 Genomic DNA. Translation: AAO69449.1.
AF213333 Genomic DNA. Translation: AAF21055.1.
RefSeqiNP_455588.1. NC_003198.1.
WP_001166955.1. NZ_LUHL01000048.1.

Genome annotation databases

EnsemblBacteriaiAAO69449; AAO69449; t1828.
CAD08217; CAD08217; CAD08217.
GeneIDi1247536.
KEGGistt:t1828.
sty:STY1121.
PATRICi18540114. VBISalEnt120419_1124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD08217.1.
AE014613 Genomic DNA. Translation: AAO69449.1.
AF213333 Genomic DNA. Translation: AAF21055.1.
RefSeqiNP_455588.1. NC_003198.1.
WP_001166955.1. NZ_LUHL01000048.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220341.STY1121.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO69449; AAO69449; t1828.
CAD08217; CAD08217; CAD08217.
GeneIDi1247536.
KEGGistt:t1828.
sty:STY1121.
PATRICi18540114. VBISalEnt120419_1124.

Phylogenomic databases

eggNOGiENOG4108N4M. Bacteria.
ENOG410Y7WM. LUCA.
HOGENOMiHOG000028303.
KOiK13085.
OMAiCWNCKSG.

Family and domain databases

InterProiIPR008108. IpgD/SopB.
[Graphical view]
PfamiPF05925. IpgD. 1 hit.
[Graphical view]
PRINTSiPR01734. TYPE3OMBPROT.
ProtoNetiSearch...

Entry informationi

Entry nameiSOPB_SALTI
AccessioniPrimary (citable) accession number: Q8Z7R1
Secondary accession number(s): Q7C973, Q9RER3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.