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Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi156ZincUniRule annotation1
Metal bindingi176ZincUniRule annotation1
Metal bindingi178ZincUniRule annotation1
Metal bindingi183ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi4 – 11ATPUniRule annotation8
Nucleotide bindingi133 – 139ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCarbohydrate metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00544

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
Alternative name(s):
GlcNAc kinaseUniRule annotation
Gene namesi
Name:nagKUniRule annotation
Ordered Locus Names:STY1260, t1700
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002701131 – 302N-acetyl-D-glucosamine kinaseAdd BLAST302

Proteomic databases

PRIDEiQ8Z7H9

Interactioni

Protein-protein interaction databases

STRINGi220341.STY1260

Structurei

3D structure databases

ProteinModelPortaliQ8Z7H9
SMRiQ8Z7H9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EZX Bacteria
COG1940 LUCA
HOGENOMiHOG000150087
KOiK00884
OMAiLQLNYHA

Family and domain databases

HAMAPiMF_01271 GlcNAc_kinase, 1 hit
InterProiView protein in InterPro
IPR023505 N-acetyl-D-glucosamine_kinase
IPR000600 ROK
PANTHERiPTHR18964 PTHR18964, 1 hit
PfamiView protein in Pfam
PF00480 ROK, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Z7H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYYGFDIGGT KIALGVFDST RRLQWEKRVP TPHTSYSAFL DAVCELVAEA
60 70 80 90 100
DQRFGVKGSV GIGIPGMPET EDGTLYAANV PAASGKPLRA DLSARLDRDV
110 120 130 140 150
RLDNDANCFA LSEAWDDEFT QYPLVMGLIL GTGGGGLVLN GKPITGQSYI
160 170 180 190 200
TGEFGHMRLP VDALTLMGFD FPLRRCGCGQ MGCIENYLSG RGFAWLYQHY
210 220 230 240 250
YDQSLQAPEI IALWEQGDEQ AHAHVERYLD LLAVCLGNIL TIVDPDLLVI
260 270 280 290 300
GGGLSNFTAI TTQLAERLPR HLLPVARAPR IERARHGDAG GMRGAAFLHL

TD
Length:302
Mass (Da):32,902
Last modified:March 1, 2002 - v1
Checksum:iE1B5BB467F94144C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD08344.1
AE014613 Genomic DNA Translation: AAO69325.1
RefSeqiNP_455712.1, NC_003198.1
WP_000291327.1, NZ_PHKG01000027.1

Genome annotation databases

EnsemblBacteriaiAAO69325; AAO69325; t1700
CAD08344; CAD08344; CAD08344
GeneIDi1247663
KEGGistt:t1700
sty:STY1260
PATRICifig|220341.7.peg.1264

Similar proteinsi

Entry informationi

Entry nameiNAGK_SALTI
AccessioniPrimary (citable) accession number: Q8Z7H9
Secondary accession number(s): Q7C9E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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