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Q8Z7H9

- NAGK_SALTI

UniProt

Q8Z7H9 - NAGK_SALTI

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Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi156 – 1561ZincUniRule annotation
Metal bindingi176 – 1761ZincUniRule annotation
Metal bindingi178 – 1781ZincUniRule annotation
Metal bindingi183 – 1831ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 118ATPUniRule annotation
Nucleotide bindingi133 – 1397ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
  2. peptidoglycan turnover Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
Alternative name(s):
GlcNAc kinaseUniRule annotation
Gene namesi
Name:nagKUniRule annotation
Ordered Locus Names:STY1260, t1700
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302N-acetyl-D-glucosamine kinasePRO_0000270113Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220341.STY1260.

Structurei

3D structure databases

ProteinModelPortaliQ8Z7H9.
SMRiQ8Z7H9. Positions 1-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
KOiK00884.
OMAiATFQLAN.
OrthoDBiEOG61P6P0.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8Z7H9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYYGFDIGGT KIALGVFDST RRLQWEKRVP TPHTSYSAFL DAVCELVAEA
60 70 80 90 100
DQRFGVKGSV GIGIPGMPET EDGTLYAANV PAASGKPLRA DLSARLDRDV
110 120 130 140 150
RLDNDANCFA LSEAWDDEFT QYPLVMGLIL GTGGGGLVLN GKPITGQSYI
160 170 180 190 200
TGEFGHMRLP VDALTLMGFD FPLRRCGCGQ MGCIENYLSG RGFAWLYQHY
210 220 230 240 250
YDQSLQAPEI IALWEQGDEQ AHAHVERYLD LLAVCLGNIL TIVDPDLLVI
260 270 280 290 300
GGGLSNFTAI TTQLAERLPR HLLPVARAPR IERARHGDAG GMRGAAFLHL

TD
Length:302
Mass (Da):32,902
Last modified:March 1, 2002 - v1
Checksum:iE1B5BB467F94144C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD08344.1.
AE014613 Genomic DNA. Translation: AAO69325.1.
RefSeqiNP_455712.1. NC_003198.1.
NP_805476.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO69325; AAO69325; t1700.
CAD08344; CAD08344; CAD08344.
GeneIDi1247663.
KEGGisty:STY1260.
PATRICi18540397. VBISalEnt120419_1264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD08344.1 .
AE014613 Genomic DNA. Translation: AAO69325.1 .
RefSeqi NP_455712.1. NC_003198.1.
NP_805476.1. NC_004631.1.

3D structure databases

ProteinModelPortali Q8Z7H9.
SMRi Q8Z7H9. Positions 1-302.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220341.STY1260.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO69325 ; AAO69325 ; t1700 .
CAD08344 ; CAD08344 ; CAD08344 .
GeneIDi 1247663.
KEGGi sty:STY1260.
PATRICi 18540397. VBISalEnt120419_1264.

Phylogenomic databases

eggNOGi COG1940.
HOGENOMi HOG000150087.
KOi K00884.
OMAi ATFQLAN.
OrthoDBi EOG61P6P0.

Enzyme and pathway databases

UniPathwayi UPA00544 .

Family and domain databases

HAMAPi MF_01271. GlcNAc_kinase.
InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view ]
Pfami PF00480. ROK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiNAGK_SALTI
AccessioniPrimary (citable) accession number: Q8Z7H9
Secondary accession number(s): Q7C9E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3