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Protein

Tryptophan biosynthesis protein TrpCF

Gene

trpC

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).By similarity

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 and 4 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Tryptophan biosynthesis protein TrpCF (trpC)
  4. Tryptophan biosynthesis protein TrpCF (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Isomerase, Lyase, Multifunctional enzyme
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042
UPA00035; UER00043

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan biosynthesis protein TrpCF
Including the following 2 domains:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpC
Ordered Locus Names:STY1326, t1637
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001542831 – 452Tryptophan biosynthesis protein TrpCFAdd BLAST452

Proteomic databases

PRIDEiQ8Z7D9

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi220341.STY1326

Structurei

3D structure databases

ProteinModelPortaliQ8Z7D9
SMRiQ8Z7D9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 256Indole-3-glycerol phosphate synthaseAdd BLAST256
Regioni257 – 452N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST196

Sequence similaritiesi

In the N-terminal section; belongs to the TrpC family.Curated
In the C-terminal section; belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiENOG4105DK0 Bacteria
COG0134 LUCA
COG0135 LUCA
HOGENOMiHOG000280458
KOiK13498
OMAiYDIIGIN

Family and domain databases

CDDicd00331 IGPS, 1 hit
cd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 2 hits
HAMAPiMF_00134_B IGPS_B, 1 hit
MF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR013798 Indole-3-glycerol_P_synth
IPR001468 Indole-3-GlycerolPSynthase_CS
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00218 IGPS, 1 hit
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 2 hits
PROSITEiView protein in PROSITE
PS00614 IGPS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Z7D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTVLAKIVA DKAIWVEARK QQQPLASFQN EIQPSTRHFY DALQGARTAF
60 70 80 90 100
ILECKKASPS KGVIRDDFDP ARIASIYQHY ASAISVLTDE KYFQGSFDFL
110 120 130 140 150
PVVSQSAPQP ILCKDFIIDP YQIYLARYYQ ADACLLMLSV LDDEQYRQLS
160 170 180 190 200
AVAHSLKMGV LTEISNDEER ERAIALGAKV VGINNRDLRD LSIDLNRTRQ
210 220 230 240 250
LAPKLGHGVT VISESGINTY GQVRELSHFA NGFLIGSALM AHDDLNAAVR
260 270 280 290 300
RVLLGENKVC GLTRAQDAKA ACDAGAIYGG LIFVPSSPRA VSVEQAREVI
310 320 330 340 350
SGAPLQYVGV FKNADIADVC QKAAVLSLSA VQLHGSEDQA YVNALREALP
360 370 380 390 400
RNVQIWKALS VSNALPARDY HHVDKYIFDN GQGGSGQRFD WSLLQGQPLD
410 420 430 440 450
DVLLAGGLAA DNCVQAAQVG CAGLDFNSGV ESQPGIKDAR LLASVFQTLR

AY
Length:452
Mass (Da):49,230
Last modified:March 1, 2002 - v1
Checksum:iE602F9F59D1DA70E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD08407.1
AE014613 Genomic DNA Translation: AAO69264.1
RefSeqiNP_455773.1, NC_003198.1
WP_001195287.1, NZ_LT904886.1

Genome annotation databases

EnsemblBacteriaiAAO69264; AAO69264; t1637
CAD08407; CAD08407; CAD08407
GeneIDi1247726
KEGGistt:t1637
sty:STY1326
PATRICifig|220341.7.peg.1333

Similar proteinsi

Entry informationi

Entry nameiTRPC_SALTI
AccessioniPrimary (citable) accession number: Q8Z7D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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