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Q8Z7D9

- TRPC_SALTI

UniProt

Q8Z7D9 - TRPC_SALTI

Protein

Tryptophan biosynthesis protein TrpCF

Gene

trpC

Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain By similarity.By similarity

    Catalytic activityi

    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
    1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

    Pathwayi

    GO - Molecular functioni

    1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
    2. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Isomerase, Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00035; UER00042.
    UPA00035; UER00043.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan biosynthesis protein TrpCF
    Including the following 2 domains:
    Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
    Short name:
    IGPS
    N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
    Gene namesi
    Name:trpC
    Ordered Locus Names:STY1326, t1637
    OrganismiSalmonella typhi
    Taxonomic identifieri90370 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Tryptophan biosynthesis protein TrpCFPRO_0000154283Add
    BLAST

    Proteomic databases

    PRIDEiQ8Z7D9.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi220341.STY1326.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8Z7D9.
    SMRiQ8Z7D9. Positions 1-452.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 256256Indole-3-glycerol phosphate synthaseAdd
    BLAST
    Regioni257 – 452196N-(5'-phosphoribosyl)anthranilate isomeraseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the TrpC family.Curated
    In the C-terminal section; belongs to the TrpF family.Curated

    Phylogenomic databases

    eggNOGiCOG0134.
    HOGENOMiHOG000280458.
    KOiK13498.
    OMAiEKYFQGD.
    OrthoDBiEOG6WT8JX.

    Family and domain databases

    Gene3Di3.20.20.70. 2 hits.
    HAMAPiMF_00134_B. IGPS_B.
    MF_00135. PRAI.
    InterProiIPR013785. Aldolase_TIM.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001468. Indole-3-GlycerolPSynthase_CS.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00218. IGPS. 1 hit.
    PF00697. PRAI. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 2 hits.
    PROSITEiPS00614. IGPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8Z7D9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTVLAKIVA DKAIWVEARK QQQPLASFQN EIQPSTRHFY DALQGARTAF    50
    ILECKKASPS KGVIRDDFDP ARIASIYQHY ASAISVLTDE KYFQGSFDFL 100
    PVVSQSAPQP ILCKDFIIDP YQIYLARYYQ ADACLLMLSV LDDEQYRQLS 150
    AVAHSLKMGV LTEISNDEER ERAIALGAKV VGINNRDLRD LSIDLNRTRQ 200
    LAPKLGHGVT VISESGINTY GQVRELSHFA NGFLIGSALM AHDDLNAAVR 250
    RVLLGENKVC GLTRAQDAKA ACDAGAIYGG LIFVPSSPRA VSVEQAREVI 300
    SGAPLQYVGV FKNADIADVC QKAAVLSLSA VQLHGSEDQA YVNALREALP 350
    RNVQIWKALS VSNALPARDY HHVDKYIFDN GQGGSGQRFD WSLLQGQPLD 400
    DVLLAGGLAA DNCVQAAQVG CAGLDFNSGV ESQPGIKDAR LLASVFQTLR 450
    AY 452
    Length:452
    Mass (Da):49,230
    Last modified:March 1, 2002 - v1
    Checksum:iE602F9F59D1DA70E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD08407.1.
    AE014613 Genomic DNA. Translation: AAO69264.1.
    RefSeqiNP_455773.1. NC_003198.1.
    NP_805415.1. NC_004631.1.

    Genome annotation databases

    EnsemblBacteriaiAAO69264; AAO69264; t1637.
    CAD08407; CAD08407; CAD08407.
    GeneIDi1247726.
    KEGGisty:STY1326.
    PATRICi18540535. VBISalEnt120419_1333.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD08407.1 .
    AE014613 Genomic DNA. Translation: AAO69264.1 .
    RefSeqi NP_455773.1. NC_003198.1.
    NP_805415.1. NC_004631.1.

    3D structure databases

    ProteinModelPortali Q8Z7D9.
    SMRi Q8Z7D9. Positions 1-452.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220341.STY1326.

    Proteomic databases

    PRIDEi Q8Z7D9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO69264 ; AAO69264 ; t1637 .
    CAD08407 ; CAD08407 ; CAD08407 .
    GeneIDi 1247726.
    KEGGi sty:STY1326.
    PATRICi 18540535. VBISalEnt120419_1333.

    Phylogenomic databases

    eggNOGi COG0134.
    HOGENOMi HOG000280458.
    KOi K13498.
    OMAi EKYFQGD.
    OrthoDBi EOG6WT8JX.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00042 .
    UPA00035 ; UER00043 .

    Family and domain databases

    Gene3Di 3.20.20.70. 2 hits.
    HAMAPi MF_00134_B. IGPS_B.
    MF_00135. PRAI.
    InterProi IPR013785. Aldolase_TIM.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001468. Indole-3-GlycerolPSynthase_CS.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00218. IGPS. 1 hit.
    PF00697. PRAI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 2 hits.
    PROSITEi PS00614. IGPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CT18.
    2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
      Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
      J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700931 / Ty2.

    Entry informationi

    Entry nameiTRPC_SALTI
    AccessioniPrimary (citable) accession number: Q8Z7D9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3