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Protein

Fumarate and nitrate reduction regulatory protein

Gene

fnr

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O2, is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration (By similarity).By similarity

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi20Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi23Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi29Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi122Iron-sulfur (4Fe-4S)Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi197 – 216H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate and nitrate reduction regulatory protein
Gene namesi
Name:fnr
Ordered Locus Names:STY1404, t1564
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001001661 – 250Fumarate and nitrate reduction regulatory proteinAdd BLAST250

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi220341.STY1404

Structurei

3D structure databases

ProteinModelPortaliQ8Z787
SMRiQ8Z787
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 237HTH crp-typePROSITE-ProRule annotationAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 29Essential for the oxygen-regulated activityBy similarity10
Regioni47 – 50Activating region 2ASequence analysis4
Regioni60 – 61Activating region 3ASequence analysis2
Regioni71 – 75Activating region 1ASequence analysis5
Regioni81Activating region 3BSequence analysis1
Regioni85 – 87Activating region 3CSequence analysis3
Regioni112Activating region 3DSequence analysis1
Regioni116 – 121Activating region 1BSequence analysis6
Regioni123 – 124Activating region 2BSequence analysis2
Regioni127 – 128Activating region 2CSequence analysis2
Regioni140 – 159DimerizationSequence analysisAdd BLAST20
Regioni181 – 191Activating region 1CSequence analysisAdd BLAST11

Phylogenomic databases

eggNOGiENOG4105DS0 Bacteria
COG0664 LUCA
HOGENOMiHOG000186461
KOiK01420
OMAiAEVCVMP

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di1.10.10.10, 1 hit
2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR012318 HTH_CRP
IPR014710 RmlC-like_jellyroll
IPR018335 Tscrpt_reg_HTH_Crp-type_CS
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF13545 HTH_Crp_2, 1 hit
PRINTSiPR00034 HTHCRP
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00419 HTH_CRP, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS00042 HTH_CRP_1, 1 hit
PS51063 HTH_CRP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Z787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPEKRIIRR IQSGGCAIHC QDCSISQLCI PFTLNEHELD QLDNIIERKK
60 70 80 90 100
PIQKGQTLFK AGDELKSLYA IRSGTIKSYT ITEQGDEQIT GFHLAGDLVG
110 120 130 140 150
FDAIGSGHHP SFAQALETSM VCKIPFETLD DLSGKMPNLR QQMMRLMSGE
160 170 180 190 200
IKGDQDMILL LSKKNAEERL AAFIYNLSRR FAQRGFSPRE FRLTMTRGDI
210 220 230 240 250
GNYLGLTVET ISRLLGRFQK SGMLAVKGKY ITIENSDALA ALAGHTRNVA
Length:250
Mass (Da):27,882
Last modified:August 30, 2002 - v2
Checksum:i05EBCFA29727CD2C
GO

Sequence cautioni

The sequence AAO69195 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD01670 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD01670.1 Different initiation.
AE014613 Genomic DNA Translation: AAO69195.1 Different initiation.
PIRiAE0662
RefSeqiNP_455844.3, NC_003198.1

Genome annotation databases

EnsemblBacteriaiAAO69195; AAO69195; t1564
CAD01670; CAD01670; CAD01670
GeneIDi1247799
KEGGistt:t1564
sty:STY1404
PATRICifig|220341.7.peg.1414

Similar proteinsi

Entry informationi

Entry nameiFNR_SALTI
AccessioniPrimary (citable) accession number: Q8Z787
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: March 28, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health