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Protein

Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive

Gene

aroH

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).By similarity

Catalytic activityi

Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.

Pathwayi: chorismate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive (aroF), Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive (aroH), Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroD)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase 2 (aroL), Shikimate kinase 1 (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00053; UER00084

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive (EC:2.5.1.54)
Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
DAHP synthase
Phospho-2-keto-3-deoxyheptonate aldolase
Gene namesi
Name:aroH
Ordered Locus Names:STY1763, t1228
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001408441 – 348Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitiveAdd BLAST348

Interactioni

Protein-protein interaction databases

STRINGi220341.STY1763

Structurei

3D structure databases

ProteinModelPortaliQ8Z6I9
SMRiQ8Z6I9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I DAHP synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105E99 Bacteria
COG0722 LUCA
HOGENOMiHOG000220501
KOiK01626
OMAiPCLSWED

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR006218 DAHP1/KDSA
IPR006219 DHAP_synth_1
PANTHERiPTHR21225 PTHR21225, 1 hit
PfamiView protein in Pfam
PF00793 DAHP_synth_1, 1 hit
PIRSFiPIRSF001361 DAHP_synthase, 1 hit
TIGRFAMsiTIGR00034 aroFGH, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Z6I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRTDELRTA RIDSLVTPTE LAQRYPVSSS VASHVTDSRR RIEKILNGED
60 70 80 90 100
PRLLVVIGPC SIHDLNAAME YATQLQAQRQ KHQARLEIVM RTYFEKPRTV
110 120 130 140 150
VGWKGLISDP DLNGSYRVNH GLELARRLLL QVNELGVPTA TEFLDMVTGQ
160 170 180 190 200
FIADLISWGT IGARTTESQI HREMASALSC PVGFKNGTDG NTRIAVDAIR
210 220 230 240 250
ASRASHMFLS PDKDGQMTIY QTSGNPYGHI IMRGGKKPNY HAEDIAAACD
260 270 280 290 300
TLHEFDLPEH LVVDFSHGNC QKQHRRQLDV CDDICQQIRN GSTAIAGIMA
310 320 330 340
ESFLREGTQK IISGQPLIYG QSITDPCLNW EDTEVLLEKL AAAVDSRF
Length:348
Mass (Da):38,740
Last modified:March 1, 2002 - v1
Checksum:i48C8E23B2F8088A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD02005.1
AE014613 Genomic DNA Translation: AAO68883.1
RefSeqiNP_456164.1, NC_003198.1
WP_001082192.1, NZ_PHKG01000017.1

Genome annotation databases

EnsemblBacteriaiAAO68883; AAO68883; t1228
CAD02005; CAD02005; CAD02005
GeneIDi1248134
KEGGistt:t1228
sty:STY1763
PATRICifig|220341.7.peg.1775

Entry informationi

Entry nameiAROH_SALTI
AccessioniPrimary (citable) accession number: Q8Z6I9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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