Reviewed, UniProtKB/Swiss-Prot Q8Z6G1 (ASTD_SALTI)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	STY1809, t1184

Organism

Salmonella typhi [Complete proteome] [HAMAP]

Taxonomic identifier

601 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH.
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Sequence caution	The sequence AAO68840.1 differs from that shown. Reason: Erroneous termination at position 429. Translated as Trp. The sequence CAD02049.1 differs from that shown. Reason: Erroneous termination at position 429. Translated as Trp.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	N-succinylglutamate 5-semialdehyde dehydrogenase		PRO_0000262421
Regions
	Nucleotide binding	220 – 225	6	NAD By similarity
Sites
	Active site	243	1	By similarity
	Active site	277	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8Z6G1-1 [UniParc]. Last modified November 28, 2006. Version 2. Checksum: 037656582563AF41	FASTA	492	53,212
	10 20 30 40 50 60 MTLWINGDWI TGQGERRRKT NPVSEEILWQ GNDADAAQVA EACQAARAAF PRWARQPFAA 70 80 90 100 110 120 RQAIVEKFSV LLEAHKADLT EVIARETGKP RWEAATEVTA MINKIAISIK AYHARTGEQK 130 140 150 160 170 180 SELVDGAATL RHRPHGVLAV FGPYNFPGHL PNGHIVPALL AGNTLIFKPS ELTPWTGETV 190 200 210 220 230 240 IKLWERAGLP AGVLNLVQGG RETGQALSSL DDLDGLLFTG SASTGYQLHR QLSGQPEKIL 250 260 270 280 290 300 ALEMGGNNPL IIEDATNMDA AVHLTLQSAF ITAGQRCTCA RRLLVKQGAQ GDAFLARLVD 310 320 330 340 350 360 VAGRLQPGRW DDDPQPFIGG LISAQAAQHV MEAWRQREAL GGRTLLAPRK VKEGTSLLTP 370 380 390 400 410 420 GIIELTGVAD VPDEEVFGPL LNVWRYAHFD EAIRLANNTR FGLSCGLVST DRAQFEQLLL 430 440 450 460 470 480 EARAGIVNWN KPLTGAASTA PFGGVGASGN HRPSAWYAAD YCAWPMASLE SPELTLPATL 490 SPGLDFSRRE AV

References

[1]

"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18." Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. , Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:848-852(2001) [PubMed: 11677608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT18.

[2]

"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18." Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R. J. Bacteriol. 185:2330-2337(2003) [PubMed: 12644504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700931 / Ty2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL627271 Genomic DNA. Translation: CAD02049.1. Sequence problems. AE014613 Genomic DNA. Translation: AAO68840.1. Sequence problems.
RefSeq	NP_456207.1. NP_804991.1.
3D structure databases
HSSP	HSSP built from PDB template 1O9J based on UniProtKB Q28399.
ModBase	Search...
Genome annotation databases
GeneID	1070602. 1248178.
GenomeReviews	Gene locus STY1809 in contig AL513382_GR. Gene locus t1184 in contig AE014613_GR.
KEGG	stt:t1184. sty:STY1809.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8Z6G1.
Enzyme and pathway databases
BioCyc	SENT209261:T1184-MON. SENT220341:STY1809-MON.
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR015590. Aldehyde_DHase. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_SALTI

Accession

Primary (citable) accession number: Q8Z6G1
Secondary accession number(s): Q7CA95

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	November 25, 2008
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)