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Q8Z6F6

- DHE4_SALTI

UniProt

Q8Z6F6 - DHE4_SALTI

Protein

NADP-specific glutamate dehydrogenase

Gene

gdhA

Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.By similarity

    Catalytic activityi

    L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei92 – 921SubstrateBy similarity
    Binding sitei113 – 1131SubstrateBy similarity
    Binding sitei116 – 1161SubstrateBy similarity
    Active sitei128 – 1281Proton donorPROSITE-ProRule annotation
    Binding sitei167 – 1671Substrate; via carbonyl oxygenBy similarity
    Sitei168 – 1681Important for catalysisBy similarity
    Binding sitei211 – 2111NADPBy similarity
    Binding sitei242 – 2421NADPBy similarity
    Binding sitei380 – 3801SubstrateBy similarity

    GO - Molecular functioni

    1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB

    GO - Biological processi

    1. glutamate biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
    Short name:
    NADP-GDH
    Gene namesi
    Name:gdhA
    Ordered Locus Names:STY1815, t1178
    OrganismiSalmonella typhi
    Taxonomic identifieri90370 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 447447NADP-specific glutamate dehydrogenasePRO_0000182775Add
    BLAST

    Proteomic databases

    PRIDEiQ8Z6F6.

    Interactioni

    Subunit structurei

    Homohexamer.By similarity

    Protein-protein interaction databases

    STRINGi220341.STY1815.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8Z6F6.
    SMRiQ8Z6F6. Positions 6-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0334.
    HOGENOMiHOG000243799.
    KOiK00262.
    OMAiIMLDIHA.
    OrthoDBiEOG65XN4D.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000185. Glu_DH. 1 hit.
    PRINTSiPR00082. GLFDHDRGNASE.
    SMARTiSM00839. ELFV_dehydrog. 1 hit.
    [Graphical view]
    PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8Z6F6-1 [UniParc]FASTAAdd to Basket

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    MDQTCSLESF LNHVQKRDPH QTEFAQAVRE VMTTLWPFLE QNPRYRHMSL    50
    LERLVEPERV IQFRVVWLDD KNQVQVNRAW RVQFNSAIGP YKGGMRFHPS 100
    VNLSILKFLG FEQTFKNALT TLPMGGGKGG SDFDPKGKSE GEVMRFCQAL 150
    MTELYRHLGP DTDVPAGDIG VGGREVGFMA GMMRKLSNNS ACVFTGKGLS 200
    FGGSLIRPEA TGYGLVYFTE AMLKRHGLGF EGMRVAVSGS GNVAQYAIEK 250
    AMAFGARVVT ASDSSGTVVD ESGFTPEKLA RLCEIKASRD GRVADYAREF 300
    GLTYLEGQQP WSVPVDIALP CATQNELDVD AARVLIANGV KAVAEGANMP 350
    TTIEATDLFL EAGVLFAPGK AANAGGVATS GLEMAQNAAR LSWKAEKVDA 400
    RLHHIMLDIH HACVKYGGDN KHTNYVQGAN IAGFVKVADA MLAQGVI 447
    Length:447
    Mass (Da):48,557
    Last modified:March 1, 2002 - v1
    Checksum:iC557D9AB5EF8E0A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD02055.1.
    AE014613 Genomic DNA. Translation: AAO68835.1.
    RefSeqiNP_456213.1. NC_003198.1.
    NP_804986.1. NC_004631.1.

    Genome annotation databases

    EnsemblBacteriaiAAO68835; AAO68835; t1178.
    CAD02055; CAD02055; CAD02055.
    GeneIDi1248184.
    KEGGisty:STY1815.
    PATRICi18541532. VBISalEnt120419_1828.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD02055.1 .
    AE014613 Genomic DNA. Translation: AAO68835.1 .
    RefSeqi NP_456213.1. NC_003198.1.
    NP_804986.1. NC_004631.1.

    3D structure databases

    ProteinModelPortali Q8Z6F6.
    SMRi Q8Z6F6. Positions 6-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220341.STY1815.

    Proteomic databases

    PRIDEi Q8Z6F6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO68835 ; AAO68835 ; t1178 .
    CAD02055 ; CAD02055 ; CAD02055 .
    GeneIDi 1248184.
    KEGGi sty:STY1815.
    PATRICi 18541532. VBISalEnt120419_1828.

    Phylogenomic databases

    eggNOGi COG0334.
    HOGENOMi HOG000243799.
    KOi K00262.
    OMAi IMLDIHA.
    OrthoDBi EOG65XN4D.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000185. Glu_DH. 1 hit.
    PRINTSi PR00082. GLFDHDRGNASE.
    SMARTi SM00839. ELFV_dehydrog. 1 hit.
    [Graphical view ]
    PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CT18.
    2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
      Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
      J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700931 / Ty2.

    Entry informationi

    Entry nameiDHE4_SALTI
    AccessioniPrimary (citable) accession number: Q8Z6F6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3