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Q8Z6F6

- DHE4_SALTI

UniProt

Q8Z6F6 - DHE4_SALTI

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Protein

NADP-specific glutamate dehydrogenase

Gene

gdhA

Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.By similarity

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921SubstrateBy similarity
Binding sitei113 – 1131SubstrateBy similarity
Binding sitei116 – 1161SubstrateBy similarity
Active sitei128 – 1281Proton donorPROSITE-ProRule annotation
Binding sitei167 – 1671Substrate; via carbonyl oxygenBy similarity
Sitei168 – 1681Important for catalysisBy similarity
Binding sitei211 – 2111NADPBy similarity
Binding sitei242 – 2421NADPBy similarity
Binding sitei380 – 3801SubstrateBy similarity

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB

GO - Biological processi

  1. glutamate biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Gene namesi
Name:gdhA
Ordered Locus Names:STY1815, t1178
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447NADP-specific glutamate dehydrogenasePRO_0000182775Add
BLAST

Proteomic databases

PRIDEiQ8Z6F6.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi220341.STY1815.

Structurei

3D structure databases

ProteinModelPortaliQ8Z6F6.
SMRiQ8Z6F6. Positions 6-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0334.
HOGENOMiHOG000243799.
KOiK00262.
OMAiIMLDIHA.
OrthoDBiEOG65XN4D.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8Z6F6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQTCSLESF LNHVQKRDPH QTEFAQAVRE VMTTLWPFLE QNPRYRHMSL
60 70 80 90 100
LERLVEPERV IQFRVVWLDD KNQVQVNRAW RVQFNSAIGP YKGGMRFHPS
110 120 130 140 150
VNLSILKFLG FEQTFKNALT TLPMGGGKGG SDFDPKGKSE GEVMRFCQAL
160 170 180 190 200
MTELYRHLGP DTDVPAGDIG VGGREVGFMA GMMRKLSNNS ACVFTGKGLS
210 220 230 240 250
FGGSLIRPEA TGYGLVYFTE AMLKRHGLGF EGMRVAVSGS GNVAQYAIEK
260 270 280 290 300
AMAFGARVVT ASDSSGTVVD ESGFTPEKLA RLCEIKASRD GRVADYAREF
310 320 330 340 350
GLTYLEGQQP WSVPVDIALP CATQNELDVD AARVLIANGV KAVAEGANMP
360 370 380 390 400
TTIEATDLFL EAGVLFAPGK AANAGGVATS GLEMAQNAAR LSWKAEKVDA
410 420 430 440
RLHHIMLDIH HACVKYGGDN KHTNYVQGAN IAGFVKVADA MLAQGVI
Length:447
Mass (Da):48,557
Last modified:March 1, 2002 - v1
Checksum:iC557D9AB5EF8E0A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD02055.1.
AE014613 Genomic DNA. Translation: AAO68835.1.
RefSeqiNP_456213.1. NC_003198.1.
NP_804986.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO68835; AAO68835; t1178.
CAD02055; CAD02055; CAD02055.
GeneIDi1248184.
KEGGisty:STY1815.
PATRICi18541532. VBISalEnt120419_1828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD02055.1 .
AE014613 Genomic DNA. Translation: AAO68835.1 .
RefSeqi NP_456213.1. NC_003198.1.
NP_804986.1. NC_004631.1.

3D structure databases

ProteinModelPortali Q8Z6F6.
SMRi Q8Z6F6. Positions 6-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220341.STY1815.

Proteomic databases

PRIDEi Q8Z6F6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO68835 ; AAO68835 ; t1178 .
CAD02055 ; CAD02055 ; CAD02055 .
GeneIDi 1248184.
KEGGi sty:STY1815.
PATRICi 18541532. VBISalEnt120419_1828.

Phylogenomic databases

eggNOGi COG0334.
HOGENOMi HOG000243799.
KOi K00262.
OMAi IMLDIHA.
OrthoDBi EOG65XN4D.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiDHE4_SALTI
AccessioniPrimary (citable) accession number: Q8Z6F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3