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Protein

NADP-specific glutamate dehydrogenase

Gene

gdhA

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.By similarity

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92SubstrateBy similarity1
Binding sitei113SubstrateBy similarity1
Binding sitei116SubstrateBy similarity1
Active sitei128Proton donorPROSITE-ProRule annotation1
Binding sitei167Substrate; via carbonyl oxygenBy similarity1
Sitei168Important for catalysisBy similarity1
Binding sitei211NADPBy similarity1
Binding sitei242NADPBy similarity1
Binding sitei380SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Gene namesi
Name:gdhA
Ordered Locus Names:STY1815, t1178
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001827751 – 447NADP-specific glutamate dehydrogenaseAdd BLAST447

Proteomic databases

PRIDEiQ8Z6F6

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi220341.STY1815

Structurei

3D structure databases

ProteinModelPortaliQ8Z6F6
SMRiQ8Z6F6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105D82 Bacteria
COG0334 LUCA
HOGENOMiHOG000243799
KOiK00262
OMAiVHGANIC

Family and domain databases

CDDicd05313 NAD_bind_2_Glu_DH, 1 hit
InterProiView protein in InterPro
IPR006095 Glu/Leu/Phe/Val_DH
IPR033524 Glu/Leu/Phe/Val_DH_AS
IPR006096 Glu/Leu/Phe/Val_DH_C
IPR006097 Glu/Leu/Phe/Val_DH_dimer_dom
IPR014362 Glu_DH
IPR036291 NAD(P)-bd_dom_sf
IPR033922 NAD_bind_Glu_DH
PfamiView protein in Pfam
PF00208 ELFV_dehydrog, 1 hit
PF02812 ELFV_dehydrog_N, 1 hit
PIRSFiPIRSF000185 Glu_DH, 1 hit
PRINTSiPR00082 GLFDHDRGNASE
SMARTiView protein in SMART
SM00839 ELFV_dehydrog, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00074 GLFV_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Z6F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQTCSLESF LNHVQKRDPH QTEFAQAVRE VMTTLWPFLE QNPRYRHMSL
60 70 80 90 100
LERLVEPERV IQFRVVWLDD KNQVQVNRAW RVQFNSAIGP YKGGMRFHPS
110 120 130 140 150
VNLSILKFLG FEQTFKNALT TLPMGGGKGG SDFDPKGKSE GEVMRFCQAL
160 170 180 190 200
MTELYRHLGP DTDVPAGDIG VGGREVGFMA GMMRKLSNNS ACVFTGKGLS
210 220 230 240 250
FGGSLIRPEA TGYGLVYFTE AMLKRHGLGF EGMRVAVSGS GNVAQYAIEK
260 270 280 290 300
AMAFGARVVT ASDSSGTVVD ESGFTPEKLA RLCEIKASRD GRVADYAREF
310 320 330 340 350
GLTYLEGQQP WSVPVDIALP CATQNELDVD AARVLIANGV KAVAEGANMP
360 370 380 390 400
TTIEATDLFL EAGVLFAPGK AANAGGVATS GLEMAQNAAR LSWKAEKVDA
410 420 430 440
RLHHIMLDIH HACVKYGGDN KHTNYVQGAN IAGFVKVADA MLAQGVI
Length:447
Mass (Da):48,557
Last modified:March 1, 2002 - v1
Checksum:iC557D9AB5EF8E0A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD02055.1
AE014613 Genomic DNA Translation: AAO68835.1
RefSeqiNP_456213.1, NC_003198.1
WP_000372866.1, NZ_PHKG01000029.1

Genome annotation databases

EnsemblBacteriaiAAO68835; AAO68835; t1178
CAD02055; CAD02055; CAD02055
GeneIDi1248184
KEGGistt:t1178
sty:STY1815
PATRICifig|220341.7.peg.1828

Similar proteinsi

Entry informationi

Entry nameiDHE4_SALTI
AccessioniPrimary (citable) accession number: Q8Z6F6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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