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Protein

D-cysteine desulfhydrase

Gene

dcyD

Organism
Salmonella typhi
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine.UniRule annotation

Catalytic activityi

D-cysteine + H2O = H2S + NH3 + pyruvate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionLyase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
D-cysteine desulfhydraseUniRule annotation (EC:4.4.1.15UniRule annotation)
Gene namesi
Name:dcyDUniRule annotation
Ordered Locus Names:STY2161, t0923
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001845162 – 328D-cysteine desulfhydraseAdd BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi220341.STY2161.

Structurei

3D structure databases

ProteinModelPortaliQ8Z5S9.
SMRiQ8Z5S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ACC deaminase/D-cysteine desulfhydrase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105K6H. Bacteria.
COG2515. LUCA.
HOGENOMiHOG000022459.
KOiK05396.

Family and domain databases

HAMAPiMF_01045. D_Cys_desulfhydr. 1 hit.
InterProiView protein in InterPro
IPR027278. ACCD_DCysDesulf.
IPR005966. D-Cys_desShydrase.
IPR023702. D_Cys_desulphydr_bac.
IPR001926. PLP-dep.
IPR036052. Trypto_synt_PLP_dependent.
PfamiView protein in Pfam
PF00291. PALP. 1 hit.
PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01275. ACC_deam_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8Z5S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLHHLTRFP RLELIGAPTP LEYLPRLSDY LGREIYIKRD DVTPIAMGGN
60 70 80 90 100
KLRKLEFLVA DALREGADTL ITAGAIQSNH VRQTAAVAAK LGLHCVALLE
110 120 130 140 150
NPIGTTAENY LTNGNRLLLD LFNTQIEMCD ALTDPDAQLQ TLATRIEAQG
160 170 180 190 200
FRPYVIPVGG SSALGAMGYV ESALEIVQQC EEVVGLSSVV VASGSAGTHA
210 220 230 240 250
GLAVGLEHLM PDVELIGVTV SRSVAEQKPK VIALQQAIAG QLALTATADI
260 270 280 290 300
HLWDDYFAPG YGVPNDAGME AVKLLANLEG VLLDPVYTGK AMAGLIDGIS
310 320
QKRFNDDGPI LFIHTGGAPA LFAYHPHV
Length:328
Mass (Da):34,932
Last modified:January 23, 2007 - v3
Checksum:i72E49A0962EDE574
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD05702.1.
AE014613 Genomic DNA. Translation: AAO68600.1.
RefSeqiNP_456516.1. NC_003198.1.
WP_001128192.1. NZ_MXPP01000006.1.

Genome annotation databases

EnsemblBacteriaiAAO68600; AAO68600; t0923.
CAD05702; CAD05702; CAD05702.
GeneIDi1248502.
KEGGistt:t0923.
sty:STY2161.
PATRICifig|220341.7.peg.2173.

Similar proteinsi

Entry informationi

Entry nameiDCYD_SALTI
AccessioniPrimary (citable) accession number: Q8Z5S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 89 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families