Q8Z5G5 (WZB_SALTI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low molecular weight protein-tyrosine-phosphatase wzb
EC=3.1.3.48

Gene names

Name:	wzb
Ordered Locus Names:	STY2330, t0755

Organism

Salmonella typhi [Complete proteome] [HAMAP]

Taxonomic identifier

90370 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Dephosphorylates wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Pathway	Glycan metabolism; exopolysaccharide biosynthesis.
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
Biological process	Exopolysaccharide synthesis
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 149	149	Low molecular weight protein-tyrosine-phosphatase wzb		PRO_0000046574
Sites
	Active site	9	1	Nucleophile By similarity
	Active site	14	1	By similarity
	Active site	115	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8Z5G5 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: DA5DE2C3B2E83208	FASTA	149	16,504
	10 20 30 40 50 60 MFNKILVVCV GNVCRSPTAE RLLKRFHPSL TVASAGLGAL VGKGADPAAA SVASAHDLSL 70 80 90 100 110 120 ENHCARQISA RLCREYDLIL TMEKRHIAAL CDIAPEMRSK VMLFGHWDSE REIPDPYRKS 130 140 RDAFEAVYTL LERSARQWAQ ALNAEQGKP

References

[1]

"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18." Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. , Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:848-852(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT18.

[2]

"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18." Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R. J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700931 / Ty2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL627273 Genomic DNA. Translation: CAD02480.1. AE014613 Genomic DNA. Translation: AAO68448.1.
RefSeq	NP_804599.1. NC_004631.1.
3D structure databases
ProteinModelPortal	Q8Z5G5.
SMR	Q8Z5G5. Positions 1-146.
ModBase	Search...
Protein-protein interaction databases
STRING	220341.STY2330.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO68448; AAO68448; t0755. CAD02480; CAD02480; CAD02480.
GeneID	1070002.
KEGG	stt:t0755.
PATRIC	18542603. VBISalEnt120419_2351.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0394.
HOGENOM	HOG000273091.
KO	K01104.
OMA	QISRSLC.
ProtClustDB	PRK10126.
Enzyme and pathway databases
UniPathway	UPA00631.
Family and domain databases
InterPro	IPR023485. Ptyr_pPase_SF. IPR000106. Tyr_phospatase/Ars_reductase. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
PANTHER	PTHR11717. PTHR11717. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
PRINTS	PR00719. LMWPTPASE.
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
SUPFAM	SSF52788. Tyr_Pase_low_mol_wt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

WZB_SALTI

Accession

Primary (citable) accession number: Q8Z5G5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2002
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program