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Q8Z4K0 (NADB_SALTI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-aspartate oxidase
Short name=LASPO
EC=1.4.3.16
Alternative name(s):
Quinolinate synthase B
Gene names
Name:nadB
Ordered Locus Names:STY2834, t0269
OrganismSalmonella typhi [Complete proteome] [HAMAP]
Taxonomic identifier90370 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of L-aspartate to iminoaspartate.

Catalytic activity

L-aspartate + O2 = iminosuccinate + H2O2.

Cofactor

FAD.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processNAD biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionL-aspartate oxidase activity

Inferred from electronic annotation. Source: EC

L-aspartate:fumarate oxidoreductase activity

Inferred from electronic annotation. Source: EC

electron carrier activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540L-aspartate oxidase
PRO_0000184399

Regions

Nucleotide binding12 – 2615FAD Potential

Sites

Active site2441 By similarity
Active site2631 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8Z4K0 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 342785A756623204

FASTA54060,162
        10         20         30         40         50         60 
MMTTPELSCD VLIIGSGAAG LSLALRLAEK HKVIVLSKGP VSEGSTFYAQ GGIAAVFDET 

        70         80         90        100        110        120 
DSIASHVEDT LIAGAGICDR HAVEFVASNA RTCVQWLIDQ GVLFDTHVQP NGKESYHLTR 

       130        140        150        160        170        180 
EGGHSHRRIL HAADATGKEV ETTLVSRAQN HPNIQVLERS NAVDLIISDK IGLPGPRRVV 

       190        200        210        220        230        240 
GAWIWNRNKE WVETCHAKSV VLATGGASKV YQYTTNPDIS SGDGIAMAWR AGCRVANLEF 

       250        260        270        280        290        300 
NQFHPTALYH PQARNFLLTE ALRGEGAYLK RPDGSRFMPD VDERGELAPR DIVARAIDHE 

       310        320        330        340        350        360 
MKRLGADCMF LDISHKPDDF VRQHFPMIYA KLLDLGMDLT KEPIPIVPAA HYTCGGVVVD 

       370        380        390        400        410        420 
DYGRTDVDGL YAIGEVSYTG LHGANRMASN SLLECLVYGW SAAMDIDRRM PSVHSVDVLP 

       430        440        450        460        470        480 
AWDESRVENA DERVVIQHNW HELRLLMWDY VGIVRTTKRL ERALRRITML QQEIDEYYAN 

       490        500        510        520        530        540 
FRVSNNLLEL RNLVQVAELI VRCAMMRKES RGLHFTLDYP QQLAESGPSI LSPLTPHINR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL627275 Genomic DNA. Translation: CAD02790.1.
AE014613 Genomic DNA. Translation: AAO67994.1.
RefSeqNP_457117.1. NC_003198.1.
NP_804145.1. NC_004631.1.

3D structure databases

ProteinModelPortalQ8Z4K0.
SMRQ8Z4K0. Positions 5-533.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1067870.
1249143.
GenomeReviewsGene locus t0269 in contig AE014613_GR.
Gene locus STY2834 in contig AL513382_GR.
KEGGstt:t0269.
sty:STY2834.
PATRIC18543682. VBISalEnt120419_2882.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG293998.
OMAGAYIWNR.
ProtClustDBPRK09077.

Enzyme and pathway databases

BioCycSENT209261:T0269-MONOMER.
SENT220341:STY2834-MONOMER.

Family and domain databases

InterProIPR003953. FAD_bind2_N.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR004112. Fum_Rdtase/Succ_DH_flav_C.
IPR005288. NadB.
[Graphical view]
Gene3DG3DSA:1.20.58.100. Fum_Rdtase/Succ_DH_flav-like_C. 1 hit.
KOK00278.
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF46977. Succ_DH_flav_C. 1 hit.
TIGRFAMsTIGR00551. NadB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADB_SALTI
AccessionPrimary (citable) accession number: Q8Z4K0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 1, 2002
Last modified: January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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