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Reviewed, UniProtKB/Swiss-Prot Q8Z459 (CYSI_SALTI)

Last modified June 16, 2009. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Sulfite reductase [NADPH] hemoprotein beta-component
      Short name=SIR-HP
      Short name=SIRHP
    EC=1.8.1.2
Gene names
Name: cysI
Ordered Locus Names: STY3075, t2848
OrganismSalmonella typhi [Complete proteome] [HAMAP]
Taxonomic identifier90370 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

General annotation (Comments)

Function

This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate By similarity.

Catalytic activity

H2S + 3 NADP+ + 3 H2O = sulfite + 3 NADPH. HAMAP MF_01540

Cofactor

Binds 1 siroheme per subunit By similarity.

Binds 1 4Fe-4S cluster per subunit By similarity.

Subunit structure

Alpha(8)-beta4. The alpha component is a flavoprotein, the beta component is a hemoprotein By similarity.

Sequence similarities

Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 570569Sulfite reductase [NADPH] hemoprotein beta-component HAMAP MF_01540
PRO_0000199907

Sites

Metal binding4341Iron-sulfur (4Fe-4S) By similarity
Metal binding4401Iron-sulfur (4Fe-4S) By similarity
Metal binding4791Iron-sulfur (4Fe-4S) By similarity
Metal binding4831Iron (siroheme axial ligand) By similarity
Metal binding4831Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8Z459-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: B86BBE9B014F95A3

FASTA57064,028
        10         20         30         40         50         60 
MSEKYPGPLV VEGKLSDAER MKLESNYLRG TIAEDLNDGL TGGFKGDNFL LIRFHGMYQQ 

        70         80         90        100        110        120 
DDRDIRAERA AQKLEPRHAM LLRCRLPGGV ITTTQWQAID KFAADNTIYG SIRLTNRQTF 

       130        140        150        160        170        180 
QFHGILKKNV KPVHQMLHSV GLDALATAND MNRNVLCTSN PYESELHAEA YEWAKKISEH 

       190        200        210        220        230        240 
LLPRTRAYAE IWLDQEKVAT TDEEPILGQT YLPRKFKTTV VIPPQNDIDL HANDMNFVAI 

       250        260        270        280        290        300 
AENGKLVGFN LLVGGGLSIE HGNKKTYART ASEFGYLPLE HTLAVAEAVV TTQRDWGNRT 

       310        320        330        340        350        360 
DRKNAKTKYT LERVGLETFK AEVERRAGIT FEPIRPYEFT GRGDRIGWVK GIDDKWHLTL 

       370        380        390        400        410        420 
FIENGRILDY PGRPLKTGLL EIAKIHQGEF RITANQNLII ASVPESQKAK IEKLARDHGL 

       430        440        450        460        470        480 
MNAVSAQREN SMACVSFPTC PLAMAEAERF LPSFTDKVEA ILEKHGIPDE HIVMRVTGCP 

       490        500        510        520        530        540 
NGCGRAMLAE IGLVGKAPGR YNLHLGGNRI GSRIPRMYQE NITEPDIQAS LDELIGRWAK 

       550        560        570 
EREAGEGFGD FTVRAGIIRP VLDPARDFWE 

« Hide

References

Cross-references

Sequence databases

AL627276 Genomic DNA. Translation: CAD06053.1.
AE014613 Genomic DNA. Translation: AAO70405.1.
RefSeqNP_457336.1.
NP_806545.1.

3D structure databases

HSSPHSSP built from PDB template 1AOP based on UniProtKB P17846.
SMRQ8Z459. Positions 80-569, 81-570.
ModBaseSearch...

Genome annotation databases

GeneID1068743.
1249375.
GenomeReviewsGene locus t2848 in contig AE014613_GR.
Gene locus STY3075 in contig AL513382_GR.
KEGGstt:t2848.
sty:STY3075.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ8Z459.
OMAQ8Z459. ITTTQWQ.

Enzyme and pathway databases

BioCycSENT209261:T2848-MON.
SENT220341:STY3075-MON.
BRENDA1.8.1.2. 3716.

Family and domain databases

HAMAPMF_01540.
[Tree]
InterProIPR011786. CysI.
IPR006066. Nir_Si_BS.
IPR006067. Nir_Sir_4Fe4S.
IPR005117. NiRdtase/SiRdtase_haem-b_fer.
[Graphical view]
PfamPF01077. NIR_SIR. 1 hit.
PF03460. NIR_SIR_ferr. 2 hits.
[Graphical view]
PRINTSPR00397. SIROHAEM.
TIGRFAMsTIGR02041. CysI. 1 hit.
PROSITEPS00365. NIR_SIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYSI_SALTI
AccessionPrimary (citable) accession number: Q8Z459
Secondary accession number(s): Q7C7K1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: January 23, 2007
Last modified: June 16, 2009
This is version 42 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents