Q8Z3B8 (DLHH_SALTI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative carboxymethylenebutenolidase
EC=3.1.1.45

Alternative name(s):
Dienelactone hydrolase
Short name=DLH

Gene names

Name:	ysgA
Ordered Locus Names:	STY3592, t3330

Organism

Salmonella typhi [Complete proteome] [HAMAP]

Taxonomic identifier

90370 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4-carboxymethylenebut-2-en-4-olide + H2O = 4-oxohex-2-enedioate.
Sequence similarities	Belongs to the dienelactone hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	carboxymethylenebutenolidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Putative carboxymethylenebutenolidase		PRO_0000161580
Sites
	Active site	147	1	By similarity
	Active site	204	1	By similarity
	Active site	236	1	By similarity
Experimental info
	Sequence conflict	201	1	S → G in AAO70858. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8Z3B8 [UniParc]. Last modified February 21, 2002. Version 1. Checksum: 0D7630B6046075B2	FASTA	270	29,092
	10 20 30 40 50 60 MTTTHPSGFA PAASPLAPTM IHTPDGAISA GITSIPSQGD DMPAYYARPK ASDGALPVVI 70 80 90 100 110 120 VVQEIFGVHE HIRDICRRLA LEGYLAIAPE LYFREGDPND FADIPTLLSG LVAKVPDSQV 130 140 150 160 170 180 LADLDHVASW ASRNGGDAHR LMITGFCWGG RITWLYAAHN PQLKAAVAWY GKLVGDTSLN 190 200 210 220 230 240 SPKHPVDIAT DLNAPVLGLY SGQDTSIPQE SVETMRQALR AANAKAEIVV YPDAGHAFNA 250 260 270 DYRPGYHEAS AKDGWQRMLE WFAQYGGKKG

References

[1]

"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18." Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. , Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:848-852(2001) [PubMed: 11677608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT18.

[2]

"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18." Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R. J. Bacteriol. 185:2330-2337(2003) [PubMed: 12644504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700931 / Ty2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL627278 Genomic DNA. Translation: CAD07925.1. AE014613 Genomic DNA. Translation: AAO70858.1.
RefSeq	NP_457784.1. NC_003198.1.
3D structure databases
ProteinModelPortal	Q8Z3B8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1249847.
GenomeReviews	Gene locus t3330 in contig AE014613_GR. Gene locus STY3592 in contig AL513382_GR.
KEGG	stt:t3330. sty:STY3592.
PATRIC	18545290. VBISalEnt120419_3659.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG673102.
OMA	VHEHIAD.
ProtClustDB	CLSK880795.
Enzyme and pathway databases
BioCyc	SENT209261:T3330-MONOMER. SENT220341:STY3592-MONOMER.
Family and domain databases
InterPro	IPR002925. Dienelactn_hydro. [Graphical view]
KO	K01061.
Pfam	PF01738. DLH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DLHH_SALTI

Accession

Primary (citable) accession number: Q8Z3B8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2002
Last sequence update:	February 21, 2002
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program