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Q8Z307

- CAPP_SALTI

UniProt

Q8Z307 - CAPP_SALTI

Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.By similarity

    Catalytic activityi

    Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    The enzyme has distinct binding sites for each of the allosteric effectors such as acetyl-CoA, fructose 1,6-bisphosphate, guanosine 3'-diphosphate 5'-diphosphate, long chain fatty acids, and L-aspartate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei138 – 1381By similarity
    Active sitei546 – 5461By similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbon fixation Source: UniProtKB-HAMAP
    2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Carbon dioxide fixation

    Keywords - Ligandi

    Magnesium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxylase (EC:4.1.1.31)
    Short name:
    PEPC
    Short name:
    PEPCase
    Gene namesi
    Name:ppc
    Ordered Locus Names:STY3754, t3505
    OrganismiSalmonella typhi
    Taxonomic identifieri90370 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 883883Phosphoenolpyruvate carboxylasePRO_0000166621Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi220341.STY3754.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8Z307.
    SMRiQ8Z307. Positions 4-883.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEPCase type 1 family.Curated

    Phylogenomic databases

    eggNOGiCOG2352.
    HOGENOMiHOG000238648.
    KOiK01595.
    OMAiELSTISC.
    OrthoDBiEOG6TJ7T8.

    Family and domain databases

    HAMAPiMF_00595. PEPcase_type1.
    InterProiIPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PfamiPF00311. PEPcase. 1 hit.
    [Graphical view]
    PRINTSiPR00150. PEPCARBXLASE.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    PROSITEiPS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8Z307-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNEQYSALRS NVSMLGKVLG ETIKDALGEH ILDRVETIRK LSKSSRAGNE    50
    ANRQELLTTL QNLSNDELLP VARAFSQFLN LANTAEQYHS ISPKGEAASN 100
    PEVIAHTLRK LKNQPDLNDA TIKKAVESLS LELVLTAHPT EITRRTLIHK 150
    MGEINNCLKQ LDNTDIADYE RHQVMRRLRQ LIAQSWHTDE IRKQRPSPVD 200
    EAKWGFAVVE NSLWQGVPNY LRELNEQLEE NLGYKLPVDF VPVRFTSWMG 250
    GDRDGNPNVT AEITRHVLLL SRWKATDLFL KDIHVLVSEL SMVDATPELL 300
    ALVGEEGASE PYRYLMKKLR ARLMATQSWL EARLKGEKLP KPAGLLTQNE 350
    QLWEPLYACY QSLQACGMGI IANGELLDTL RRVKCFGVPL VRIDIRQEST 400
    RHTEALGEIT RYLGIGDYES WSEADKQAFL IRELNSKRPL LPRNWEPSND 450
    TREVLETCKV IAEAPKGSIA AYVISMAKTP SDVLAVHLLL KEAGIGFAMP 500
    VAPLFETLDD LNNADDVMTQ LLNIDWYRGL IQGKQMVMIG YSDSAKDAGV 550
    MAASWAQYQA QDALIKTCEK AGIELTLFHG RGGSIGRGGA PAHAALLSQP 600
    PGSLKGGLRV TEQGEMIRFK YGLPEVTVSS LSLYTSAILE ANLLPPPEPK 650
    DSWRHIMDEL SVISCETYRG YVRENKDFVP YFRSATPEQE LGKLPLGSRP 700
    AKRRPTGGVE SLRAIPWIFA WTQNRLMLPA WLGAGTALQK VVEDGKQSEL 750
    EAMCRDWPFF STRLGMLEMV FSKADLWLAD YYDQRLVAKT LWPLGKELRD 800
    LLEEDIKVVL AIANDSHLMA DLPWIAESIQ LRNVYTDPLN VLQAELLYRS 850
    RLTEEQGKSP DPRVEQALMV TIAGVAAGMR NTG 883
    Length:883
    Mass (Da):98,998
    Last modified:March 1, 2002 - v1
    Checksum:iFF98DA6606F3C66D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD09510.1.
    AE014613 Genomic DNA. Translation: AAO71013.1.
    RefSeqiNP_457940.1. NC_003198.1.
    NP_807153.1. NC_004631.1.

    Genome annotation databases

    EnsemblBacteriaiAAO71013; AAO71013; t3505.
    CAD09510; CAD09510; CAD09510.
    GeneIDi1250011.
    KEGGisty:STY3754.
    PATRICi18545668. VBISalEnt120419_3829.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD09510.1 .
    AE014613 Genomic DNA. Translation: AAO71013.1 .
    RefSeqi NP_457940.1. NC_003198.1.
    NP_807153.1. NC_004631.1.

    3D structure databases

    ProteinModelPortali Q8Z307.
    SMRi Q8Z307. Positions 4-883.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220341.STY3754.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO71013 ; AAO71013 ; t3505 .
    CAD09510 ; CAD09510 ; CAD09510 .
    GeneIDi 1250011.
    KEGGi sty:STY3754.
    PATRICi 18545668. VBISalEnt120419_3829.

    Phylogenomic databases

    eggNOGi COG2352.
    HOGENOMi HOG000238648.
    KOi K01595.
    OMAi ELSTISC.
    OrthoDBi EOG6TJ7T8.

    Family and domain databases

    HAMAPi MF_00595. PEPcase_type1.
    InterProi IPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    Pfami PF00311. PEPcase. 1 hit.
    [Graphical view ]
    PRINTSi PR00150. PEPCARBXLASE.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    PROSITEi PS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CT18.
    2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
      Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
      J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700931 / Ty2.

    Entry informationi

    Entry nameiCAPP_SALTI
    AccessioniPrimary (citable) accession number: Q8Z307
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3