Reviewed, UniProtKB/Swiss-Prot Q8Z300 (ALR3_SALTI)

Names and origin

Protein names

Recommended name:
    Alanine racemase 3
    EC=5.1.1.1

Gene names

Name:	alr3
Ordered Locus Names:	STY3763, t3513

Organism

Salmonella typhi [Complete proteome] [HAMAP]

Taxonomic identifier

90370 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the D-alanine required for cell wall biosynthesis By similarity.
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201 Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: HAMAP cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	Alanine racemase 3 HAMAP MF_01201		PRO_0000114562
Sites
	Active site	42	1	Proton acceptor; specific for D-alanine By similarity
	Active site	262	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	42	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8Z300-1 [UniParc]. Last modified March 5, 2002. Version 1. Checksum: 1338A6D2936004B3	FASTA	368	39,778
	10 20 30 40 50 60 MMKLAEIQAA CGVLCVDLAA VVDNYQTLAR HVAPAQCGAV LKANGYGLGA EAIAPALYAA 70 80 90 100 110 120 NCRIFFVAQL SEGVALRNIL SADAMVVLLN GVMPQAMPFC CAQQITPLLN SVDQVMTWLA 130 140 150 160 170 180 LQEARSQRRP VLIQLDSGMS RLGVTPEQLA RLAAIFRQRG WAAPDYIISH LANADRPDHA 190 200 210 220 230 240 LNVYQHTLLQ QAKKAFPTSR YSLANSCGMF LHPAWREDLC RPGVALFGVA QPWFSTPLKP 250 260 270 280 290 300 AFTLTLTILR VQDVPVGTPI GYGSTVTTTR PLRIATVSAG YADGIPRNLR PPAGVCWRGV 310 320 330 340 350 360 RLPVLGRVCM DSFMVDASAI MPTSGDVVEF IGVSQTLEEV AAACDTIPYE IMARLGARFR RIMQPAEA

References

[1]

"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18." Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. , Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:848-852(2001) [PubMed: 11677608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT18.

[2]

"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18." Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R. J. Bacteriol. 185:2330-2337(2003) [PubMed: 12644504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700931 / Ty2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL627279 Genomic DNA. Translation: CAD09518.1. AE014613 Genomic DNA. Translation: AAO71021.1.
RefSeq	NP_457948.1. NP_807161.1.
3D structure databases
HSSP	HSSP built from PDB template 1BD0 based on UniProtKB P10724.
ModBase	Search...
Genome annotation databases
GeneID	1069138. 1250019.
GenomeReviews	Gene locus t3513 in contig AE014613_GR. Gene locus STY3763 in contig AL513382_GR.
KEGG	stt:t3513. sty:STY3763.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8Z300.
OMA	YCTPDKI.
Enzyme and pathway databases
BioCyc	SENT209261:T3513-MON. SENT220341:STY3763-MON.
BRENDA	5.1.1.1. 3716.
Family and domain databases
HAMAP	MF_01201. [Tree]
InterPro	IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR000821. Ala_racemase_reg. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR3_SALTI

Accession

Primary (citable) accession number: Q8Z300

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	March 5, 2002
Last modified:	November 3, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)