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Q8Z2M4 (TORA_SALTI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Trimethylamine-N-oxide reductase
Short name=TMAO reductase
Short name=Trimethylamine oxidase
EC=1.7.2.3
Gene names
Name:torA
Ordered Locus Names:STY3956, t3696
OrganismSalmonella typhi [Complete proteome] [HAMAP]
Taxonomic identifier90370 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length850 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions By similarity.

Catalytic activity

Trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+.

Cofactor

Molybdenum (molybdopterin) By similarity.

Subcellular location

Periplasm By similarity.

Post-translational modification

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Sequence similarities

Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

Ontologies

Keywords
   Cellular componentPeriplasm
   DomainSignal
   LigandMolybdenum
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentperiplasmic space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionelectron carrier activity

Inferred from electronic annotation. Source: InterPro

molybdenum ion binding

Inferred from electronic annotation. Source: InterPro

trimethylamine-N-oxide reductase (cytochrome c) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3939Tat-type signal Potential
Chain40 – 850811Trimethylamine-N-oxide reductase
PRO_0000019155

Sequences

Sequence LengthMass (Da)Tools
Q8Z2M4 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 06B76E03E1FCC987

FASTA85094,675
        10         20         30         40         50         60 
MKNKDSLHVS RRRFLAQLGG LTVAGMLGPS LLTPRSARAA DAVAPGAATK EGILTGSHWG 

        70         80         90        100        110        120 
AIRATVVDGR FVAAKPFEQD KYPSKMIAGL PDHVHNAARI RYPMVRVDWM RKGHQSDTSQ 

       130        140        150        160        170        180 
RGDNRFVRVS WDEALDLFYQ ELERVQKTYG PSALLTASGW QSTGMFHNAS GMLARAIALH 

       190        200        210        220        230        240 
GNSVSTGGDY STGAAQVILP RVVGSMEVYE QQTSWPLVLQ NSKTIVLWGS DMVKNQQANW 

       250        260        270        280        290        300 
WCPDHDVYQY YEQLKEKVAS GAISVISIDP VVTSTHDYLG RDKVKHIAIN PQTDVPLQLA 

       310        320        330        340        350        360 
LAHTLYSEKL YDKNFLDNYC VGFDQFLPYL LGEKDGQPKD AAWAEKLCGI DADTIRALAR 

       370        380        390        400        410        420 
QMAGDRTQII AGWCVQRMQH GEQWSWMVVV LAAMLGQIGL PGGGFGFGWH YNGAGTPGRK 

       430        440        450        460        470        480 
GIILSGFSGS TTVPPVHDST DYKGYSSTIP IARFMDAILE PGKIINWNGK SVKLPPLKMC 

       490        500        510        520        530        540 
VFAGTNPFHR HQQINRIIEG WRKLETVIAI DNQWTSTCRF ADIVLPATTQ FERNDLDQFG 

       550        560        570        580        590        600 
NHSNRGIIAM KQVVSPQFEA RNDFDIFRDL CRRFNREAAF TEGLDEMGWL KRIWQEGSQQ 

       610        620        630        640        650        660 
GKGRGIHLPT FEVFWNQQEY IEFDHPQMFV RHQAFREDPD LEPLGTPSGL IEIYSKTIAD 

       670        680        690        700        710        720 
MQYDDCQGHP MWFEKIERSH GGPGSQRWPL HLQSVHPDFR LHSQLCESET LRQQYAVGGK 

       730        740        750        760        770        780 
EPVFINPQDA SARGIRNGDI VRVFNARGQV LAGAVVSDRY APGVARIHEG AWYDPDKGGD 

       790        800        810        820        830        840 
LNALCKYGNP NVLTLDTGTS QLAQATSAHT TLVEIEKYTG PMDNVTAFNG PAEMVAQCEY 

       850 
VPASQGNPHD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL627280 Genomic DNA. Translation: CAD03172.1.
AE014613 Genomic DNA. Translation: AAO71191.1.
RefSeqNP_458117.1. NC_003198.1.
NP_807331.1. NC_004631.1.

3D structure databases

ProteinModelPortalQ8Z2M4.
SMRQ8Z2M4. Positions 52-834.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1068717.
1250203.
GenomeReviewsGene locus t3696 in contig AE014613_GR.
Gene locus STY3956 in contig AL513382_GR.
KEGGstt:t3696.
sty:STY3956.
PATRIC18546109. VBISalEnt120419_4042.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG304064.
OMAQQYAVGG.
ProtClustDBPRK15102.

Enzyme and pathway databases

BioCycSENT209261:T3696-MONOMER.
SENT220341:STY3956-MONOMER.

Family and domain databases

InterProIPR009010. Asp_de-COase-like_fold.
IPR006658. BisC.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR006311. TAT_signal.
[Graphical view]
Gene3DG3DSA:2.40.40.20. Asp_decarboxylase-like_fold. 1 hit.
KOK07811.
PfamPF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
SUPFAMSSF50692. Asp_decarb_fold. 1 hit.
TIGRFAMsTIGR00509. BisC_fam. 1 hit.
PROSITEPS00551. MOLYBDOPTERIN_PROK_1. False negative.
PS00490. MOLYBDOPTERIN_PROK_2. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTORA_SALTI
AccessionPrimary (citable) accession number: Q8Z2M4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2002
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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