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Protein

D-serine dehydratase

Gene

dsdA

Organism
Salmonella typhi
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-serine = pyruvate + NH3.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
D-serine dehydrataseUniRule annotation (EC:4.3.1.18UniRule annotation)
Alternative name(s):
D-serine deaminaseUniRule annotation
Short name:
DSDUniRule annotation
Gene namesi
Name:dsdAUniRule annotation
Ordered Locus Names:STY3977, t3715
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440D-serine dehydratasePRO_0000185619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei116 – 1161N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi220341.STY3977.

Structurei

3D structure databases

ProteinModelPortaliQ8Z2L4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serine/threonine dehydratase family. DsdA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZC. Bacteria.
COG3048. LUCA.
HOGENOMiHOG000218072.
KOiK01753.
OMAiHCLFAEP.
OrthoDBiEOG6HXJ23.

Family and domain databases

HAMAPiMF_01030. D_Ser_dehydrat.
InterProiIPR011780. D_Ser_am_lyase.
IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PANTHERiPTHR10314:SF9. PTHR10314:SF9. 2 hits.
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR02035. D_Ser_am_lyase. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8Z2L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENILKLIAR YPLVEDLVAL KETTWFNPGA TSLAQGLPYV GLTEQDVNAA
60 70 80 90 100
HDRLARFAPY LAKAFPQTAA AGGIIESDVV AIPAMQKRLE KEYGQTIDGE
110 120 130 140 150
MLLKKDSHLA ISGSIKARGG IYEVLTHAEK LALEAGLLTT DDDYSVLLSP
160 170 180 190 200
EFKQFFSQYS IAVGSTGNLG LSIGIMSACI GFKVTVHMSA DARAWKKAKL
210 220 230 240 250
RSHGVTVVEY EDDYGVAVEQ GRKAAQSDPN CFFIDDENSR TLFLGYAVAG
260 270 280 290 300
QRLKAQFAQQ GRVVDASHPL FVYLPCGVGG GPGGVAFGLK LAFGDNVHCF
310 320 330 340 350
FAEPTHSPCM LLGVYTGLHD AISVQDIGID NLTAADGLAV GRASGFVGRA
360 370 380 390 400
MERLLDGLYT LDDQTMYDML GWLAQEEGIR LEPSALAGMA GPQRICASVA
410 420 430 440
YQQRHGFSQT QLGNATHLIW ATGGGMVPED EMEQYLAKGR
Length:440
Mass (Da):47,351
Last modified:March 1, 2002 - v1
Checksum:i5B54F6E3B4E17586
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD03191.1.
AE014613 Genomic DNA. Translation: AAO71209.1.
RefSeqiNP_458135.1. NC_003198.1.
WP_000427787.1. NZ_LUHL01000010.1.

Genome annotation databases

EnsemblBacteriaiAAO71209; AAO71209; t3715.
CAD03191; CAD03191; CAD03191.
GeneIDi1250222.
KEGGistt:t3715.
sty:STY3977.
PATRICi18546154. VBISalEnt120419_4064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD03191.1.
AE014613 Genomic DNA. Translation: AAO71209.1.
RefSeqiNP_458135.1. NC_003198.1.
WP_000427787.1. NZ_LUHL01000010.1.

3D structure databases

ProteinModelPortaliQ8Z2L4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220341.STY3977.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO71209; AAO71209; t3715.
CAD03191; CAD03191; CAD03191.
GeneIDi1250222.
KEGGistt:t3715.
sty:STY3977.
PATRICi18546154. VBISalEnt120419_4064.

Phylogenomic databases

eggNOGiENOG4105BZC. Bacteria.
COG3048. LUCA.
HOGENOMiHOG000218072.
KOiK01753.
OMAiHCLFAEP.
OrthoDBiEOG6HXJ23.

Family and domain databases

HAMAPiMF_01030. D_Ser_dehydrat.
InterProiIPR011780. D_Ser_am_lyase.
IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PANTHERiPTHR10314:SF9. PTHR10314:SF9. 2 hits.
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR02035. D_Ser_am_lyase. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiSDHD_SALTI
AccessioniPrimary (citable) accession number: Q8Z2L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.