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Protein

Protein MgtC

Gene

mgtC

Organism
Salmonella typhi
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Virulence factor required for growth in low Mg2+ medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na+/K+-ATPase (By similarity).By similarity

GO - Biological processi

  • pathogenesis Source: CACAO
Complete GO annotation...

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MgtC
Gene namesi
Name:mgtC
Ordered Locus Names:STY4022, t3754
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Protein MgtCPRO_0000250529Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220341.STY4022.

Structurei

3D structure databases

ProteinModelPortaliQ8Z2J2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MgtC/SapB family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105KT7. Bacteria.
COG1285. LUCA.
HOGENOMiHOG000080251.
KOiK07507.
OMAiNITSVRW.

Family and domain databases

InterProiIPR003416. MgtC/SapB/SrpB/YhiD_fam.
[Graphical view]
PfamiPF02308. MgtC. 1 hit.
[Graphical view]
PRINTSiPR01837. MGTCSAPBPROT.

Sequencei

Sequence statusi: Complete.

Q8Z2J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEERMLMFPY ILNLLAAMLL GALIGAERQW RQRMAGLRTN ALVATGAAVF
60 70 80 90 100
ILSSMTTSPD SPGRIAAQIV SGIGFLGAGV IMREGMNVRG LNTAATLWCS
110 120 130 140 150
AGIGVLCGLG QFKNALAATI IILCANILLR EAAQRINQLP VSAEAEKRYI
160 170 180 190 200
LKVTCNKEDE SAVRQWLLNI VKEAAICLQG LGSVPAQEQG YKEIRAELVG
210 220 230
HADYRKTREL IISRIGDNDN ITAIHWSIDS Q
Length:231
Mass (Da):25,065
Last modified:March 1, 2002 - v1
Checksum:i398DCC35BB4E30FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD03230.1.
AE014613 Genomic DNA. Translation: AAO71244.1.
RefSeqiNP_458170.1. NC_003198.1.
WP_000392697.1. NZ_LUHL01000010.1.

Genome annotation databases

EnsemblBacteriaiAAO71244; AAO71244; t3754.
CAD03230; CAD03230; CAD03230.
GeneIDi1250261.
KEGGistt:t3754.
sty:STY4022.
PATRICi18546239. VBISalEnt120419_4106.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD03230.1.
AE014613 Genomic DNA. Translation: AAO71244.1.
RefSeqiNP_458170.1. NC_003198.1.
WP_000392697.1. NZ_LUHL01000010.1.

3D structure databases

ProteinModelPortaliQ8Z2J2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220341.STY4022.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO71244; AAO71244; t3754.
CAD03230; CAD03230; CAD03230.
GeneIDi1250261.
KEGGistt:t3754.
sty:STY4022.
PATRICi18546239. VBISalEnt120419_4106.

Phylogenomic databases

eggNOGiENOG4105KT7. Bacteria.
COG1285. LUCA.
HOGENOMiHOG000080251.
KOiK07507.
OMAiNITSVRW.

Family and domain databases

InterProiIPR003416. MgtC/SapB/SrpB/YhiD_fam.
[Graphical view]
PfamiPF02308. MgtC. 1 hit.
[Graphical view]
PRINTSiPR01837. MGTCSAPBPROT.
ProtoNetiSearch...

Entry informationi

Entry nameiMGTC_SALTI
AccessioniPrimary (citable) accession number: Q8Z2J2
Secondary accession number(s): Q7C6D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.