Reviewed,
UniProtKB/Swiss-Prot Q8Z2E5 (LLDD_SALTI)
Last modified
February 9, 2010.
Version 48.
History...
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90%,
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: L-lactate dehydrogenase [cytochrome] EC=1.1.2.3 | ||||
| Gene names |
| ||||
| Organism | Salmonella typhi [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 90370 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella |
Protein attributes
| Sequence length | 396 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+. HAMAP MF_01559 |
| Cofactor | FMN By similarity. HAMAP MF_01559 |
| Sequence similarities | Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. Contains 1 FMN hydroxy acid dehydrogenase domain. |
Ontologies
| Keywords | |
|---|---|
| Ligand | FMN Flavoprotein |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | lactate metabolic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | FMN binding Inferred from electronic annotation. Source: InterPro L-lactate dehydrogenase (cytochrome) activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 396 | 396 | L-lactate dehydrogenase [cytochrome] HAMAP MF_01559 | PRO_0000206346 | |||||
Regions | |||||||||
| Domain | 1 – 380 | 380 | FMN hydroxy acid dehydrogenase | ||||||
| Nucleotide binding | 306 – 330 | 25 | FMN By similarity | ||||||
Sites | |||||||||
| Active site | 275 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 24 | 1 | Substrate Potential | ||||||
| Binding site | 106 | 1 | FMN By similarity | ||||||
| Binding site | 127 | 1 | FMN By similarity | ||||||
| Binding site | 129 | 1 | Substrate By similarity | ||||||
| Binding site | 155 | 1 | FMN By similarity | ||||||
| Binding site | 164 | 1 | Substrate By similarity | ||||||
| Binding site | 251 | 1 | FMN By similarity | ||||||
| Binding site | 278 | 1 | Substrate Potential | ||||||
Sequences
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References
| [1] | "Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18." Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. Barrell B.G.Nature 413:848-852(2001) [PubMed: 11677608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT18. |
| [2] | "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18." Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R. J. Bacteriol. 185:2330-2337(2003) [PubMed: 12644504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700931 / Ty2. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL627280 Genomic DNA. Translation: CAD03300.1. AE014613 Genomic DNA. Translation: AAO71306.1. |
| RefSeq | NP_458232.1. NP_807446.1. |
3D structure databases | |
| SMR | Q8Z2E5. Positions 1-377. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1071345. 1250331. |
| GenomeReviews | Gene locus t3825 in contig AE014613_GR. |
| KEGG | stt:t3825. sty:STY4102. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG517781. |
| OMA | WIREFWE. |
Enzyme and pathway databases | |
| BioCyc | SENT209261:T3825-MONOMER. SENT220341:STY4102-MONOMER. |
| BRENDA | 1.1.2.3. 3716. |
Family and domain databases | |
| HAMAP | MF_01559. L-lact_dehydr. [Tree] |
| InterPro | IPR012133. a-Hydoxy_acid_DH_FMN. IPR013785. Aldolase_TIM. IPR000262. FMN-dep_DH. IPR008259. FMN_hydac_DH_AS. IPR020920. L-lactate_DHase_cyt. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF01070. FMN_dh. 1 hit. [Graphical view] |
| PIRSF | PIRSF000138. Al-hdrx_acd_dh. 1 hit. |
| PROSITE | PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LLDD_SALTI | ||||||||
| Accession | Primary (citable) accession number: Q8Z2E5 Secondary accession number(s): Q7C661 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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