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Protein

Endoglucanase

Gene

bcsZ

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes carboxymethylcellulose.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Pathwayi: bacterial cellulose biosynthesis

This protein is involved in the pathway bacterial cellulose biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway bacterial cellulose biosynthesis and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei56Proton donorBy similarity1
Active sitei117NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00694

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase (EC:3.2.1.4)
Alternative name(s):
Carboxymethylcellulase
Short name:
CMCase
Cellulase
Endo-1,4-beta-glucanase
Gene namesi
Name:bcsZ
Ordered Locus Names:STY4183, t3900
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000794023 – 369EndoglucanaseAdd BLAST347

Proteomic databases

PRIDEiQ8Z289

Interactioni

Protein-protein interaction databases

STRINGi220341.STY4183

Structurei

3D structure databases

ProteinModelPortaliQ8Z289
SMRiQ8Z289
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105K2Z Bacteria
COG3405 LUCA
HOGENOMiHOG000259088
KOiK20542
OMAiIRVYLWV

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR002037 Glyco_hydro_8
IPR019834 Glyco_hydro_8_CS
PfamiView protein in Pfam
PF01270 Glyco_hydro_8, 1 hit
PRINTSiPR00735 GLHYDRLASE8
SUPFAMiSSF48208 SSF48208, 1 hit
PROSITEiView protein in PROSITE
PS00812 GLYCOSYL_HYDROL_F8, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8Z289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTMLRGWIT MIVMLTAINA QAACSWPAWE QFKKDYISQQ GRVIDPGDAR
60 70 80 90 100
KITTSEGQSY AMFFALAAND RPAFAQLFNW TQNNLAQGSL REHLPAWLWG
110 120 130 140 150
QKDPDTWSVL DSNSASDGDI WMAWSLLEAG RLWKETRYTE VGTALLKRIA
160 170 180 190 200
REEVVNVPGL GSMLLPGKIG FAEANSWRFN PSYLPPQLAQ YFSRFGAPWS
210 220 230 240 250
TLRETNLRLL LETSPKGFSP DWVRYESKQG WQLKAEKTLI SSYDAIRVYL
260 270 280 290 300
WTGMMHDGDP QKARLLARFK PMATLTMKNG VPPEKVDVVS GNAQGTGPVG
310 320 330 340 350
FSAALLPFLQ NRGAQAVQRQ RVADHFPGSD AYYNYVLTLF GQGWDQHRFR
360
FTVKGELLPD WGQECVSSR
Length:369
Mass (Da):41,703
Last modified:March 1, 2002 - v1
Checksum:i09954697C007F742
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD08008.1
AE014613 Genomic DNA Translation: AAO71375.1
RefSeqiNP_458303.1, NC_003198.1
WP_000988805.1, NZ_PHKG01000002.1

Genome annotation databases

EnsemblBacteriaiAAO71375; AAO71375; t3900
CAD08008; CAD08008; CAD08008
GeneIDi1250407
KEGGistt:t3900
sty:STY4183
PATRICifig|220341.7.peg.4272

Entry informationi

Entry nameiGUN_SALTI
AccessioniPrimary (citable) accession number: Q8Z289
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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