Q8Z289 (GUN_SALTI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Endoglucanase
EC=3.2.1.4

Alternative name(s):
Carboxymethylcellulase
Short name=CMCase
Cellulase
Endo-1,4-beta-glucanase

Gene names

Name:	bcsZ
Ordered Locus Names:	STY4183, t3900

Organism

Salmonella typhi [Complete proteome] [HAMAP]

Taxonomic identifier

90370 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes carboxymethylcellulose.
Catalytic activity	Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
Pathway	Glycan metabolism; bacterial cellulose biosynthesis.
Subcellular location	Secreted.
Sequence similarities	Belongs to the glycosyl hydrolase 8 (cellulase D) family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Cellulose degradation Polysaccharide degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellulose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cellulase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 369	347	Endoglucanase		PRO_0000007940
Sites
	Active site	56	1	Proton donor By similarity
	Active site	117	1	Nucleophile Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8Z289 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 09954697C007F742	FASTA	369	41,703
	10 20 30 40 50 60 MMTMLRGWIT MIVMLTAINA QAACSWPAWE QFKKDYISQQ GRVIDPGDAR KITTSEGQSY 70 80 90 100 110 120 AMFFALAAND RPAFAQLFNW TQNNLAQGSL REHLPAWLWG QKDPDTWSVL DSNSASDGDI 130 140 150 160 170 180 WMAWSLLEAG RLWKETRYTE VGTALLKRIA REEVVNVPGL GSMLLPGKIG FAEANSWRFN 190 200 210 220 230 240 PSYLPPQLAQ YFSRFGAPWS TLRETNLRLL LETSPKGFSP DWVRYESKQG WQLKAEKTLI 250 260 270 280 290 300 SSYDAIRVYL WTGMMHDGDP QKARLLARFK PMATLTMKNG VPPEKVDVVS GNAQGTGPVG 310 320 330 340 350 360 FSAALLPFLQ NRGAQAVQRQ RVADHFPGSD AYYNYVLTLF GQGWDQHRFR FTVKGELLPD WGQECVSSR

References

[1]

"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18." Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. , Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:848-852(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT18.

[2]

"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18." Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R. J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700931 / Ty2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL627281 Genomic DNA. Translation: CAD08008.1. AE014613 Genomic DNA. Translation: AAO71375.1.
RefSeq	NP_807515.1. NC_004631.1.
3D structure databases
ProteinModelPortal	Q8Z289.
ModBase	Search...
Protein-protein interaction databases
STRING	220341.STY4183.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO71375; AAO71375; t3900. CAD08008; CAD08008; CAD08008.
GeneID	1071146.
KEGG	stt:t3900.
PATRIC	18546576. VBISalEnt120419_4272.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3405.
HOGENOM	HOG000259088.
KO	K01179.
OMA	IRVYLWV.
ProtClustDB	PRK11097.
Enzyme and pathway databases
UniPathway	UPA00694.
Family and domain databases
Gene3D	1.50.10.10. 1 hit.
InterPro	IPR008928. 6-hairpin_glycosidase-like. IPR012341. 6hp_glycosidase. IPR002037. Glyco_hydro_8. IPR019834. Glyco_hydro_8_CS. [Graphical view]
Pfam	PF01270. Glyco_hydro_8. 1 hit. [Graphical view]
PRINTS	PR00735. GLHYDRLASE8.
SUPFAM	SSF48208. Glyco_trans_6hp. 1 hit.
PROSITE	PS00812. GLYCOSYL_HYDROL_F8. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GUN_SALTI

Accession

Primary (citable) accession number: Q8Z289

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 26, 2002
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program