Cytochrome c-552 precursor - Salmonella typhi

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Reviewed, UniProtKB/Swiss-Prot Q8Z1Q9 (NRFA_SALTI)

Last modified November 4, 2008. Version 61. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Cytochrome c-552
    EC=1.7.2.2
Alternative name(s):
    Ammonia-forming cytochrome c nitrite reductase
      Short name=Cytochrome c nitrite reductase

Gene names

Name:	nrfA
Ordered Locus Names:	STY4475, t4183

Organism

Salmonella typhi [Complete proteome] [HAMAP]

Taxonomic identifier

601 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

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Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Plays a role in nitrite reduction By similarity.
Catalytic activity	NH(3) + 2 H(2)O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H(+).
Cofactor	Binds 1 calcium ion per monomer By similarity. Binds 5 heme groups covalently per monomer By similarity.
Pathway	Nitrogen metabolism; nitrate reduction (assimilation).
Subcellular location	PeriplasmBy similarity.
Sequence similarities	Belongs to the cytochrome c-552 family.

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Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Periplasm
Domain	Signal
Ligand	Calcium Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW nitrogen compound metabolic process Inferred from electronic annotation. Source: HAMAP transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	periplasmic space Inferred from electronic annotation. Source: HAMAP
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW nitrite reductase (cytochrome, ammonia-forming) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 26

By similarity

Chain

27 – 478

452

Cytochrome c-552

PRO_0000006581

Sites

Metal binding

Iron (heme 3 axial ligand) By similarity

Metal binding

126

Iron (heme 1 axial ligand) By similarity

Metal binding

164

Iron (heme 2 axial ligand) By similarity

Metal binding

213

Iron (heme 3 axial ligand) By similarity

Metal binding

215

Calcium By similarity

Metal binding

216

Calcium; via carbonyl oxygen By similarity

Metal binding

261

Calcium; via carbonyl oxygen By similarity

Metal binding

263

Calcium By similarity

Metal binding

275

Iron (heme 5 axial ligand) By similarity

Metal binding

286

Iron (heme 4 axial ligand) By similarity

Metal binding

301

Iron (heme 2 axial ligand) By similarity

Metal binding

318

Iron (heme 5 axial ligand) By similarity

Metal binding

393

Iron (heme 4 axial ligand) By similarity

Binding site

122

Heme 1 (covalent) By similarity

Binding site

125

Heme 1 (covalent) By similarity

Binding site

160

Heme 2 (covalent) By similarity

Binding site

163

Heme 2 (covalent) By similarity

Binding site

209

Heme 3 (covalent) By similarity

Binding site

212

Heme 3 (covalent) By similarity

Binding site

216

Substrate By similarity

Binding site

264

Substrate By similarity

Binding site

282

Heme 4 (covalent) By similarity

Binding site

285

Heme 4 (covalent) By similarity

Binding site

314

Heme 5 (covalent) By similarity

Binding site

317

Heme 5 (covalent) By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q8Z1Q9-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 9190792F7300CE88
Show »

FASTA

478

53,727

        10         20         30         40         50         60 
MARKTLRARR FFSLIFPFFF ITSVYAEQTP VSAKTVTVEA KNETFAPQHP DQYQSWKATS 

        70         80         90        100        110        120 
EQSAREDALA EDPRLVILWA GYPFSRDYNK PRGHAYAVTD VRETLRTGAP KTAEDGPLPM 

       130        140        150        160        170        180 
ACWSCKSPDV ARLIQQEGED GYFHGKWARG GPEIVNDLGC ADCHNTASDD FAQGKPAITL 

       190        200        210        220        230        240 
SRPYAERAME AIGKPFDKAG RFDQQSMVCG QCHVEYYFDG KNKAVKFPWD EGMKVENMEQ 

       250        260        270        280        290        300 
YYDAIAFSDW TNSLSKTPML KAQHPEYETW SAGIHGKNNV TCIDCHMPKV QNAEGKLYTD 

       310        320        330        340        350        360 
HKIGNPFDNF AQTCANCHTQ DKASLQKVVA ERKQAIHDLK IKVEDQLVHA HFEAKAAWDA 

       370        380        390        400        410        420 
GATDAEMKPI LNDIRHAQWR WDLAIASHGI HMHAPEEGLR MLGSAMDKAA DARTKLARLL 

       430        440        450        460        470 
ATKGITHEIP LPDISTKEKA QKAIGLNMQQ INAEKQDFLK TVVPQWEDQA RKNGLLSQ

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References

[1]

"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18."
Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P.

Barrell B.G.
Nature 413:848-852(2001) [PubMed: 11677608] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CT18.

[2]

"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
J. Bacteriol. 185:2330-2337(2003) [PubMed: 12644504] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700931 / Ty2.

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Cross-references

Sequence databases
	AL627282 Genomic DNA. Translation: CAD09261.1. AE014613 Genomic DNA. Translation: AAO71647.1.
RefSeq	NP_458575.1. NP_807787.1.
3D structure databases
HSSP	HSSP built from PDB template 1GU6 based on UniProtKB P32050.
SMR	Q8Z1Q9. Positions 38-478.
ModBase	Search...
Genome annotation databases
GeneID	1069632. 1250690.
GenomeReviews	Gene locus STY4475 in contig AL513382_GR. Gene locus t4183 in contig AE014613_GR.
KEGG	stt:t4183. sty:STY4475.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8Z1Q9.
Enzyme and pathway databases
BioCyc	SENT209261:T4183-MON. SENT220341:STY4475-MON.
Family and domain databases
HAMAP	MF_01182. [Tree]
InterPro	IPR003321. Cyt_c552. IPR017570. Cytc_552_NO2Rdtase_formate-dep. IPR011031. Multihaem_cyt. [Graphical view]
Pfam	PF02335. Cytochrom_C552. 1 hit. [Graphical view]
PIRSF	PIRSF000243. Cyt_c552. 1 hit.
PROSITE	PS51008. MULTIHEME_CYTC. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

NRFA_SALTI

Accession

Primary (citable) accession number: Q8Z1Q9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	March 1, 2002
Last modified:	November 4, 2008
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Sequence annotation (Features)

Molecule processing

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents