Q8Z153 (CYSQ_SALTI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3'(2'),5'-bisphosphate nucleotidase CysQ
EC=3.1.3.7

Alternative name(s):
3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase
3'-phosphoadenosine 5'-phosphate phosphatase
Short name=PAP phosphatase
DPNPase

Gene names

Name:	cysQ
Ordered Locus Names:	STY4762, t4457

Organism

Salmonella typhi [Complete proteome] [HAMAP]

Taxonomic identifier

90370 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) By similarity.
Catalytic activity	Adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate.
Cofactor	Magnesium By similarity.
Subcellular location	Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Sequence similarities	Belongs to the inositol monophosphatase family.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Cytoplasm Membrane
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'(2'),5'-bisphosphate nucleotidase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	3'(2'),5'-bisphosphate nucleotidase CysQ		PRO_0000142544
Regions
	Region	85 – 88	4	Substrate binding By similarity
Sites
	Metal binding	64	1	Magnesium 1 By similarity
	Metal binding	83	1	Magnesium 1 By similarity
	Metal binding	83	1	Magnesium 2 By similarity
	Metal binding	85	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	86	1	Magnesium 2 By similarity
	Metal binding	205	1	Magnesium 2 By similarity
	Binding site	64	1	Substrate By similarity
	Binding site	205	1	Substrate By similarity
Experimental info
	Sequence conflict	96	1	R → G in AAO71904. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8Z153 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 9BEE7F56A9A576CA	FASTA	246	27,589
	10 20 30 40 50 60 MLEQVCQLAR NAGDAIMQVY DGAKPMEYAR KQDDSPVTAA DIAAHTVILE GLRTLTPDIP 70 80 90 100 110 120 VLSEEDPPAW EVRQHWQRYW LVDPLDGTKE FIKRNREFTV NIALIEQGKP VLGVVYAPVL 130 140 150 160 170 180 KVMYYAAEGK AWKEECGVRK QIQVRDARPP LVVISRSHTD DELTEYLQQL GEHQTTSIGS 190 200 210 220 230 240 SLKFCLVAEG QAQLYPRFGP TSVWDTAAGH AIAVAAGAHV HDWQGKTLDY TPRESFLNPG FRVTIY

References

[1]

"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18." Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. , Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:848-852(2001) [PubMed: 11677608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT18.

[2]

"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18." Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R. J. Bacteriol. 185:2330-2337(2003) [PubMed: 12644504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700931 / Ty2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL627283 Genomic DNA. Translation: CAD06883.1. AE014613 Genomic DNA. Translation: AAO71904.1.
RefSeq	NP_458840.1. NC_003198.1.
3D structure databases
ProteinModelPortal	Q8Z153.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1250964.
GenomeReviews	Gene locus t4457 in contig AE014613_GR. Gene locus STY4762 in contig AL513382_GR.
KEGG	stt:t4457. sty:STY4762.
PATRIC	18547778. VBISalEnt120419_4864.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG730251.
OMA	TYEWDTA.
ProtClustDB	PRK10931.
Enzyme and pathway databases
BioCyc	SENT209261:T4457-MONOMER. SENT220341:STY4762-MONOMER.
Family and domain databases
InterPro	IPR006240. Bisphos_bac. IPR020583. Inositol_monoP_metal-BS. IPR000760. Inositol_monophosphatase. IPR020550. Inositol_monophosphatase_CS. [Graphical view]
KO	K01082.
PANTHER	PTHR20854. Inositol_P. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
TIGRFAMs	TIGR01331. Bisphos_cysQ. 1 hit.
PROSITE	PS00629. IMP_1. 1 hit. PS00630. IMP_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYSQ_SALTI

Accession

Primary (citable) accession number: Q8Z153

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 23, 2003
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program