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Q8Z127 (OTCC_SALTI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3
Gene names
Name:arcB
Ordered Locus Names:STY4803, t4499
OrganismSalmonella typhi [Complete proteome] [HAMAP]
Taxonomic identifier90370 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109

Pathway

Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109

Subcellular location

Cytoplasm Probable HAMAP MF_01109.

Sequence similarities

Belongs to the ATCase/OTCase family.

Ontologies

Keywords
   Biological processArginine metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentornithine carbamoyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Ornithine carbamoyltransferase, catabolic HAMAP MF_01109
PRO_0000113003

Regions

Region57 – 615Carbamoyl phosphate binding By similarity
Region274 – 2774Ornithine binding By similarity

Sites

Binding site1081Carbamoyl phosphate By similarity
Binding site1351Carbamoyl phosphate By similarity
Site321Important for structural integrity By similarity
Site1481Important for structural integrity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8Z127 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 94C36699FC43C6A5

FASTA33436,834
        10         20         30         40         50         60 
MVISLKNRNF LKLLDYTPAE IQHLIDLAIE LKAAKKAGCE KQTLIGKNIA LIFEKTSTRT 

        70         80         90        100        110        120 
RCAFEVAAFD QGAQVTYLGP SGSQIGHKES MKDTARVLGR MYDGIEYRGF GQHIVEELGE 

       130        140        150        160        170        180 
YAGVPVWNGL TDEFHPTQIL ADLMTMLEHA PGKTLPELSF AYLGDARNNM GNSLMVGAAK 

       190        200        210        220        230        240 
MGMDIRLIAP KSFWPDAALV AQCREIASVT GARITLTESV EDGVHGVDFL YTDVWVSMGE 

       250        260        270        280        290        300 
PKEAWAERVS LMTPYQVNQQ VVNATGNPDV KFMHCLPAFH NEHTKVGREI EMAYGLKGLE 

       310        320        330 
VTEEVFESAG SMVFDEAENR MHTIKAVMVA TLGD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL627283 Genomic DNA. Translation: CAD06925.1.
AE014613 Genomic DNA. Translation: AAO71946.1.
RefSeqNP_458882.1. NC_003198.1.
NP_808086.1. NC_004631.1.

3D structure databases

ProteinModelPortalQ8Z127.
SMRQ8Z127. Positions 7-332.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1068133.
1251006.
GenomeReviewsGene locus t4499 in contig AE014613_GR.
Gene locus STY4803 in contig AL513382_GR.
KEGGstt:t4499.
sty:STY4803.
PATRIC18547872. VBISalEnt120419_4911.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG579429.
OMAMTPYQIN.
ProtClustDBPRK02102.

Enzyme and pathway databases

BioCycSENT209261:T4499-MONOMER.
SENT220341:STY4803-MONOMER.

Family and domain databases

HAMAPMF_01109. OTCase.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
KOK00611.
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00658. Orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTCC_SALTI
AccessionPrimary (citable) accession number: Q8Z127
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2002
Last modified: January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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