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Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.UniRule annotation

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotation

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (deoC)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei102Proton donor/acceptorUniRule annotation1
Active sitei167Schiff-base intermediate with acetaldehydeUniRule annotation1
Active sitei201Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandSchiff base

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolaseUniRule annotation (EC:4.1.2.4UniRule annotation)
Short name:
DERAUniRule annotation
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolaseUniRule annotation
PhosphodeoxyriboaldolaseUniRule annotation
Short name:
DeoxyriboaldolaseUniRule annotation
Gene namesi
Name:deoCUniRule annotation
Ordered Locus Names:STY4918, t4610
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000573011 – 259Deoxyribose-phosphate aldolaseAdd BLAST259

Interactioni

Protein-protein interaction databases

STRINGi220341.STY4918

Structurei

3D structure databases

ProteinModelPortaliQ8Z0U3
SMRiQ8Z0U3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105FCI Bacteria
COG0274 LUCA
HOGENOMiHOG000241644
KOiK01619
OMAiMNACIPP

Family and domain databases

CDDicd00959 DeoC, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00592 DeoC_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011343 DeoC
IPR002915 DeoC/FbaB/lacD_aldolase
IPR023649 DeoC_typeII
PANTHERiPTHR10889 PTHR10889, 1 hit
PfamiView protein in Pfam
PF01791 DeoC, 1 hit
PIRSFiPIRSF001357 DeoC, 1 hit
SMARTiView protein in SMART
SM01133 DeoC, 1 hit
TIGRFAMsiTIGR00126 deoC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Z0U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLKASSLR ALKLMDLTTL NDDDTNEKVI ALCHQAKTPV GNTAAICIYP
60 70 80 90 100
RFIPIARKTL KEQGTPDIRI ATVTNFPHGN DDIDIALAET RAAIAYGADE
110 120 130 140 150
VDVVFPYRAL IAGNEQVGFD LVKACKDACA AANVLLKVII ETGELKEEAL
160 170 180 190 200
IRKASEISIK AGADFIKTST GKVPVNATPE SARIMMEVIR DMGVSKTVGF
210 220 230 240 250
KPAGGVRTAE DAQKFLAIAD ELFGANWADS RHYRFGASSL LASLLKALGH

GDGKSASSY
Length:259
Mass (Da):27,684
Last modified:November 1, 2002 - v2
Checksum:i7E488C83AAC06DD5
GO

Sequence cautioni

The sequence AAO72042 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD03402 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD03402.1 Different initiation.
AE014613 Genomic DNA Translation: AAO72042.1 Different initiation.
PIRiAC1073
RefSeqiNP_458979.1, NC_003198.1

Genome annotation databases

EnsemblBacteriaiAAO72042; AAO72042; t4610
CAD03402; CAD03402; CAD03402
GeneIDi1251113
KEGGistt:t4610
sty:STY4918
PATRICifig|220341.7.peg.5039

Similar proteinsi

Entry informationi

Entry nameiDEOC_SALTI
AccessioniPrimary (citable) accession number: Q8Z0U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 2002
Last modified: March 28, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health