Reviewed, UniProtKB/Swiss-Prot Q8Z0M2 (RNPH_ANASP)

Names and origin

Protein names

Recommended name:
    Ribonuclease PH
      Short name=RNase PH
    EC=2.7.7.56
Alternative name(s):
    tRNA nucleotidyltransferase

Gene names

Name:	rph
Ordered Locus Names:	alr0069

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates By similarity.
Catalytic activity	tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate. HAMAP MF_00564
Sequence similarities	Belongs to the RNase PH family.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tRNA processing Inferred from electronic annotation. Source: HAMAP
Molecular function	3'-5'-exoribonuclease activity Inferred from electronic annotation. Source: InterPro tRNA binding Inferred from electronic annotation. Source: HAMAP tRNA nucleotidyltransferase activity Inferred from electronic annotation. Source: HAMAP tRNA-specific ribonuclease activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 247	247	Ribonuclease PH HAMAP MF_00564		PRO_0000139860

Sequences

	Sequence		Length	Mass (Da)
	Q8Z0M2-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: F805AE720656C095	FASTA	247	27,152
	10 20 30 40 50 60 MVWQRPDGRK PYELRPINFH TKFTRFAPGS VLTICGETKV LCTVSVAESV PKFLTGSGKG 70 80 90 100 110 120 WLTAEYRMLP SATQQRHERE LLKLSGRTQE IQRLIGRSLR AALDFEALGE RTLTVDADVL 130 140 150 160 170 180 QADAGTRTAA ITGGFVALAE AISQLLQRGV LERSPLCGQI AAVSVGLLEQ EAYLDLNYIE 190 200 210 220 230 240 DVAATVDFNV VMNKNLGIIE VQGTAEEGSF SRTQLNQLLD CAETGIQQLL IAQQQAITDW DRLFVGK

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000019 Genomic DNA. Translation: BAB77593.1.
PIR	AE1815.
RefSeq	NP_484113.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8Z0M2.
Genome annotation databases
GeneID	1103666.
GenomeReviews	Gene locus alr0069 in contig BA000019_GR.
KEGG	ana:alr0069.
NMPDR	fig|103690.1.peg.380.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8Z0M2.
OMA	YAMLPRA.
Enzyme and pathway databases
BioCyc	NSP103690:ALR0069-MON.
Family and domain databases
HAMAP	MF_00564. [Tree]
InterPro	IPR001247. ExoRNase_PH_dom1. IPR015847. ExoRNase_PH_dom2. IPR018336. Ribonuclease-PH_CS. IPR002381. RNase_PH_bac-type. [Graphical view]
Pfam	PF01138. RNase_PH. 1 hit. PF03725. RNase_PH_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR01966. RNasePH. 1 hit.
PROSITE	PS01277. RIBONUCLEASE_PH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNPH_ANASP

Accession

Primary (citable) accession number: Q8Z0M2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	March 1, 2002
Last modified:	November 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)