Reviewed, UniProtKB/Swiss-Prot Q8Z0I7 (KGUA_ANASP)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	alr0106

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity HAMAP MF_00328.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Guanylate kinase HAMAP MF_00328		PRO_0000170489
Regions
	Domain	20 – 198	179	Guanylate kinase-like
	Nucleotide binding	27 – 34	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8Z0I7-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 58634498D484850D	FASTA	199	22,099
	10 20 30 40 50 60 MMQVLSIQNC ATTKENPLSG KLIILTGPSG VGKGTLMRSL LQRHPELYYS VSATTRPPRP 70 80 90 100 110 120 GEVNGESYYF VSRSKFEELI AQGEFLESAE FAGNYYGTPR EAVLNQVQSG KLVVLEIELA 130 140 150 160 170 180 GARQIRTSFP EALSIFILPP SFEELENRIR GRGQDSEEAI ARRLQRAKEE IQAADEFDIQ 190 IVNDDFEAAL QAIEVALFG

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB77630.1.
PIR	AB1820.
RefSeq	NP_484150.1.
3D structure databases
SMR	Q8Z0I7. Positions 19-196.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8Z0I7.
Genome annotation databases
GeneID	1103703.
GenomeReviews	Gene locus alr0106 in contig BA000019_GR.
KEGG	ana:alr0106.
NMPDR	fig|103690.1.peg.417.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0194.
HOGENOM	HBG671982.
OMA	EWAEFAG.
PhylomeDB	Q8Z0I7.
Enzyme and pathway databases
BioCyc	NSP103690:ALR0106-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_ANASP

Accession

Primary (citable) accession number: Q8Z0I7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	March 1, 2002
Last modified:	February 9, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)