Reviewed, UniProtKB/Swiss-Prot Q8Z076 (NU1C_ANASP)

Names and origin

Protein names

Recommended name:
    NAD(P)H-quinone oxidoreductase subunit 1
    EC=1.6.5.-
Alternative name(s):
    NAD(P)H dehydrogenase I subunit 1
    NDH-1 subunit 1
    NDH-A

Gene names

Name:	ndhA
Ordered Locus Names:	alr0223

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01350
Subunit structure	NDH-1 is composed of at least 11 different subunits By similarity.
Subcellular location	Cellular thylakoid membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the complex I subunit 1 family.

Ontologies

Keywords
Cellular component	Membrane Thylakoid
Domain	Transmembrane
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: HAMAP
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 372	372	NAD(P)H-quinone oxidoreductase subunit 1 HAMAP MF_01350		PRO_0000117518
Regions
	Transmembrane	27 – 47	21	Potential
	Transmembrane	65 – 85	21	Potential
	Transmembrane	97 – 117	21	Potential
	Transmembrane	128 – 148	21	Potential
	Transmembrane	166 – 186	21	Potential
	Transmembrane	204 – 224	21	Potential
	Transmembrane	266 – 286	21	Potential
	Transmembrane	308 – 328	21	Potential
	Transmembrane	347 – 367	21	Potential
Experimental info
	Sequence conflict	201	1	D → G in CAB44668. Ref.1
	Sequence conflict	348 – 361	14	LLPVG…LLTAA → CYQLVSEPTFNRQP Ref.1
	Sequence conflict	368 – 371	4	VAFG → RPSA in CAB44668. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8Z076-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 6113B32DE8B34794	FASTA	372	40,320
	10 20 30 40 50 60 MNSGIDLQGT FIKSLIDLGI PPGTAKAIWM PLPMILMLIG ATVGVLVCVW LERKISAAAQ 70 80 90 100 110 120 QRIGPEYIGP LGLLAPVADG LKLVFKEDIV PAQADPWLFT LGPILVVLPV FLSYLIVPFG 130 140 150 160 170 180 QNIVITNVGT GIFLWIALSS IQPIGLLMAG YSSNNKYSLL GGLRAAAQSI SYEIPLALSV 190 200 210 220 230 240 LAIVMMSNSL STVDIVNQQS DYGILGWNIW RQPLGFMIFW IAALAECERL PFDLPEAEEE 250 260 270 280 290 300 LVAGYQTEYS GMKFALFYLS SYVNLILSAL LVAVLYLGGW DFPIPINVLA NLVGVSEANP 310 320 330 340 350 360 VLQVVSAALG ITMTLVKAYF LVFIAILLRW TVPRVRIDQL LDLGWKFLLP VGLVNLLLTA 370 ALKLAFPVAF GG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of the ndhAIGE gene cluster of Anabaena sp. PCC 7120." Schiefer W., Happe T. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ242867 Genomic DNA. Translation: CAB44668.1. BA000019 Genomic DNA. Translation: BAB77747.1.
PIR	AG1834.
RefSeq	NP_484267.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1103820.
GenomeReviews	Gene locus alr0223 in contig BA000019_GR.
KEGG	ana:alr0223.
NMPDR	fig|103690.1.peg.534.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8Z076.
OMA	Q8Z076. LYLGGWE.
Enzyme and pathway databases
BioCyc	NSP103690:ALR0223-MON.
Family and domain databases
HAMAP	MF_01350. [Tree]
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
PANTHER	PTHR11432. Resp_NADH_DH_1. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU1C_ANASP

Accession

Primary (citable) accession number: Q8Z076
Secondary accession number(s): Q9WWM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
Last sequence update:	March 1, 2002
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)