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Q8Z076 (NU1C_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD(P)H-quinone oxidoreductase subunit 1

EC=1.6.5.-
Alternative name(s):
NAD(P)H dehydrogenase I subunit 1
NDH-1 subunit 1
NDH-A
Gene names
Name:ndhA
Ordered Locus Names:alr0223
OrganismNostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]
Taxonomic identifier103690 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01350

Catalytic activity

NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01350

Subunit structure

NDH-1 is composed of at least 11 different subunits By similarity.

Subcellular location

Cellular thylakoid membrane; Multi-pass membrane protein By similarity HAMAP MF_01350.

Sequence similarities

Belongs to the complex I subunit 1 family.

Ontologies

Keywords
   Cellular componentMembrane
Thylakoid
   DomainTransmembrane
Transmembrane helix
   LigandNAD
NADP
Plastoquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

thylakoid membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionoxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-KW

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372NAD(P)H-quinone oxidoreductase subunit 1 HAMAP MF_01350
PRO_0000117518

Regions

Transmembrane27 – 4721Helical; Potential
Transmembrane65 – 8521Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane128 – 14821Helical; Potential
Transmembrane166 – 18621Helical; Potential
Transmembrane204 – 22421Helical; Potential
Transmembrane266 – 28621Helical; Potential
Transmembrane308 – 32821Helical; Potential
Transmembrane347 – 36721Helical; Potential

Experimental info

Sequence conflict2011D → G in CAB44668. Ref.1
Sequence conflict348 – 36114LLPVG…LLTAA → CYQLVSEPTFNRQP Ref.1
Sequence conflict368 – 3714VAFG → RPSA in CAB44668. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8Z076 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 6113B32DE8B34794

FASTA37240,320
        10         20         30         40         50         60 
MNSGIDLQGT FIKSLIDLGI PPGTAKAIWM PLPMILMLIG ATVGVLVCVW LERKISAAAQ 

        70         80         90        100        110        120 
QRIGPEYIGP LGLLAPVADG LKLVFKEDIV PAQADPWLFT LGPILVVLPV FLSYLIVPFG 

       130        140        150        160        170        180 
QNIVITNVGT GIFLWIALSS IQPIGLLMAG YSSNNKYSLL GGLRAAAQSI SYEIPLALSV 

       190        200        210        220        230        240 
LAIVMMSNSL STVDIVNQQS DYGILGWNIW RQPLGFMIFW IAALAECERL PFDLPEAEEE 

       250        260        270        280        290        300 
LVAGYQTEYS GMKFALFYLS SYVNLILSAL LVAVLYLGGW DFPIPINVLA NLVGVSEANP 

       310        320        330        340        350        360 
VLQVVSAALG ITMTLVKAYF LVFIAILLRW TVPRVRIDQL LDLGWKFLLP VGLVNLLLTA 

       370 
ALKLAFPVAF GG 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of the ndhAIGE gene cluster of Anabaena sp. PCC 7120."
Schiefer W., Happe T.
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120."
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takazawa M., Yamada M., Yasuda M., Tabata S.
DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7120 / UTEX 2576.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ242867 Genomic DNA. Translation: CAB44668.1.
BA000019 Genomic DNA. Translation: BAB77747.1.
PIRAG1834.
RefSeqNP_484267.1. NC_003272.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ8Z076.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1103820.
GenomeReviewsGene locus alr0223 in contig BA000019_GR.
KEGGana:alr0223.
NMPDRfig|103690.1.peg.534.
PATRIC22770173. VBINosSp37423_0579.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1005.
HOGENOMHBG727670.
OMAWNIFLQP.
PhylomeDBQ8Z076.
ProtClustDBPRK06076.

Enzyme and pathway databases

BioCycNSP103690:ALR0223-MONOMER.

Family and domain databases

HAMAPMF_01350. NDH1_NuoH.
[Tree]
InterProIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
KOK05572.
PANTHERPTHR11432. Resp_NADH_DH_1. 1 hit.
PfamPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNU1C_NOSS1
AccessionPrimary (citable) accession number: Q8Z076
Secondary accession number(s): Q9WWM7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: March 1, 2002
Last modified: January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families