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Q8Z064

- AMPA_NOSS1

UniProt

Q8Z064 - AMPA_NOSS1

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Protein
Probable cytosol aminopeptidase
Gene
pepA, alr0237
Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.

Cofactori

Binds 2 manganese ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi260 – 2601Manganese 2 By similarity
Metal bindingi265 – 2651Manganese 1 By similarity
Metal bindingi265 – 2651Manganese 2 By similarity
Active sitei272 – 2721 Reviewed prediction
Metal bindingi284 – 2841Manganese 2 By similarity
Metal bindingi343 – 3431Manganese 1 By similarity
Metal bindingi345 – 3451Manganese 1 By similarity
Metal bindingi345 – 3451Manganese 2 By similarity
Active sitei347 – 3471 Reviewed prediction

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Manganese, Metal-binding

Protein family/group databases

MEROPSiM17.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidase (EC:3.4.11.1)
Alternative name(s):
Leucine aminopeptidase (EC:3.4.11.10)
Short name:
LAP
Leucyl aminopeptidase
Gene namesi
Name:pepA
Ordered Locus Names:alr0237
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Probable cytosol aminopeptidaseUniRule annotation
PRO_0000165716Add
BLAST

Proteomic databases

PRIDEiQ8Z064.

Interactioni

Protein-protein interaction databases

STRINGi103690.alr0237.

Structurei

3D structure databases

ProteinModelPortaliQ8Z064.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.

Phylogenomic databases

eggNOGiCOG0260.
HOGENOMiHOG000243129.
KOiK01255.
OMAiARACEDN.
OrthoDBiEOG6FV8B3.

Family and domain databases

HAMAPiMF_00181. Cytosol_peptidase_M17.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PfamiPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8Z064-1 [UniParc]FASTAAdd to Basket

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MAIQLSDKPL LEWAGDTLAI ALFEDAVELT GELGSLDEKF AGILKELITE    50
EEFTGKANST VFTRVSSNIP VRKIILVGLG KTEAFKIETL RRAAAAVGKV 100
GKKQKSKVIG LSFPLWNNDP TASAQAIAEG LQLALYQDNR FKSDPEDKGS 150
QVETVELLGF AGQEAAINRA NQIVSGVILA RQLVAAPANS VTPITMAETA 200
QQIAQDYGLQ IEILEQEDCE KLGMGAFLGV ALASDLPPKF IHLTYKPEGT 250
PKRKLAIVGK GLTFDSGGLN IKGAGSGIET MKIDMGGAAA TLGAAKAIAQ 300
IKPNVEVHFI SAVTENMISG KAMHPGDILT ASNGKTIEVN NTDAEGRLTL 350
ADALVYTDKL GLDAIVDLAT LTGANVIALG DDIAGLYTPD DALAGQLEQA 400
ASESGEKIWR MPLEEKYFEG LKSGIADMKN TGPRPGGSIT AALFLKQFVK 450
DTAWAHLDIA GPVWADKENG YNGPGATGYG VRLLVDWVLS E 491
Length:491
Mass (Da):51,918
Last modified:March 1, 2002 - v1
Checksum:i4A5BE617F48ACEEE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB77761.1.
PIRiAE1836.
RefSeqiNP_484281.1. NC_003272.1.
WP_010994414.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB77761; BAB77761; BAB77761.
GeneIDi1103834.
KEGGiana:alr0237.
PATRICi22770201. VBINosSp37423_0593.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB77761.1 .
PIRi AE1836.
RefSeqi NP_484281.1. NC_003272.1.
WP_010994414.1. NC_003272.1.

3D structure databases

ProteinModelPortali Q8Z064.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.alr0237.

Protein family/group databases

MEROPSi M17.002.

Proteomic databases

PRIDEi Q8Z064.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB77761 ; BAB77761 ; BAB77761 .
GeneIDi 1103834.
KEGGi ana:alr0237.
PATRICi 22770201. VBINosSp37423_0593.

Phylogenomic databases

eggNOGi COG0260.
HOGENOMi HOG000243129.
KOi K01255.
OMAi ARACEDN.
OrthoDBi EOG6FV8B3.

Family and domain databases

HAMAPi MF_00181. Cytosol_peptidase_M17.
InterProi IPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view ]
Pfami PF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view ]
PRINTSi PR00481. LAMNOPPTDASE.
PROSITEi PS00631. CYTOSOL_AP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiAMPA_NOSS1
AccessioniPrimary (citable) accession number: Q8Z064
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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