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Q8Z064

- AMPA_NOSS1

UniProt

Q8Z064 - AMPA_NOSS1

Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    • Comment

    Functioni

    Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotation

    Catalytic activityi

    Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
    Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

    Cofactori

    Binds 2 manganese ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi260 – 2601Manganese 2UniRule annotation
    Metal bindingi265 – 2651Manganese 1UniRule annotation
    Metal bindingi265 – 2651Manganese 2UniRule annotation
    Active sitei272 – 2721UniRule annotation
    Metal bindingi284 – 2841Manganese 2UniRule annotation
    Metal bindingi343 – 3431Manganese 1UniRule annotation
    Metal bindingi345 – 3451Manganese 1UniRule annotation
    Metal bindingi345 – 3451Manganese 2UniRule annotation
    Active sitei347 – 3471UniRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. metalloexopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Keywords - Ligandi

    Manganese, Metal-binding

    Protein family/group databases

    MEROPSiM17.002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytosol aminopeptidaseUniRule annotation (EC:3.4.11.1UniRule annotation)
    Alternative name(s):
    Leucine aminopeptidaseUniRule annotation (EC:3.4.11.10UniRule annotation)
    Short name:
    LAPUniRule annotation
    Leucyl aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepAUniRule annotation
    Ordered Locus Names:alr0237
    OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
    Taxonomic identifieri103690 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000002483: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Probable cytosol aminopeptidasePRO_0000165716Add
    BLAST

    Proteomic databases

    PRIDEiQ8Z064.

    Interactioni

    Protein-protein interaction databases

    STRINGi103690.alr0237.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8Z064.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M17 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0260.
    HOGENOMiHOG000243129.
    KOiK01255.
    OMAiARACEDN.
    OrthoDBiEOG6FV8B3.

    Family and domain databases

    HAMAPiMF_00181. Cytosol_peptidase_M17.
    InterProiIPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view]
    PfamiPF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view]
    PRINTSiPR00481. LAMNOPPTDASE.
    PROSITEiPS00631. CYTOSOL_AP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8Z064-1 [UniParc]FASTAAdd to Basket

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    MAIQLSDKPL LEWAGDTLAI ALFEDAVELT GELGSLDEKF AGILKELITE    50
    EEFTGKANST VFTRVSSNIP VRKIILVGLG KTEAFKIETL RRAAAAVGKV 100
    GKKQKSKVIG LSFPLWNNDP TASAQAIAEG LQLALYQDNR FKSDPEDKGS 150
    QVETVELLGF AGQEAAINRA NQIVSGVILA RQLVAAPANS VTPITMAETA 200
    QQIAQDYGLQ IEILEQEDCE KLGMGAFLGV ALASDLPPKF IHLTYKPEGT 250
    PKRKLAIVGK GLTFDSGGLN IKGAGSGIET MKIDMGGAAA TLGAAKAIAQ 300
    IKPNVEVHFI SAVTENMISG KAMHPGDILT ASNGKTIEVN NTDAEGRLTL 350
    ADALVYTDKL GLDAIVDLAT LTGANVIALG DDIAGLYTPD DALAGQLEQA 400
    ASESGEKIWR MPLEEKYFEG LKSGIADMKN TGPRPGGSIT AALFLKQFVK 450
    DTAWAHLDIA GPVWADKENG YNGPGATGYG VRLLVDWVLS E 491
    Length:491
    Mass (Da):51,918
    Last modified:March 1, 2002 - v1
    Checksum:i4A5BE617F48ACEEE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB77761.1.
    PIRiAE1836.
    RefSeqiNP_484281.1. NC_003272.1.
    WP_010994414.1. NC_003272.1.

    Genome annotation databases

    EnsemblBacteriaiBAB77761; BAB77761; BAB77761.
    GeneIDi1103834.
    KEGGiana:alr0237.
    PATRICi22770201. VBINosSp37423_0593.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000019 Genomic DNA. Translation: BAB77761.1 .
    PIRi AE1836.
    RefSeqi NP_484281.1. NC_003272.1.
    WP_010994414.1. NC_003272.1.

    3D structure databases

    ProteinModelPortali Q8Z064.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 103690.alr0237.

    Protein family/group databases

    MEROPSi M17.002.

    Proteomic databases

    PRIDEi Q8Z064.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB77761 ; BAB77761 ; BAB77761 .
    GeneIDi 1103834.
    KEGGi ana:alr0237.
    PATRICi 22770201. VBINosSp37423_0593.

    Phylogenomic databases

    eggNOGi COG0260.
    HOGENOMi HOG000243129.
    KOi K01255.
    OMAi ARACEDN.
    OrthoDBi EOG6FV8B3.

    Family and domain databases

    HAMAPi MF_00181. Cytosol_peptidase_M17.
    InterProi IPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view ]
    Pfami PF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00481. LAMNOPPTDASE.
    PROSITEi PS00631. CYTOSOL_AP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7120 / UTEX 2576.

    Entry informationi

    Entry nameiAMPA_NOSS1
    AccessioniPrimary (citable) accession number: Q8Z064
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3