Q8YZ80 (DXS_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	alr0599

Organism

Nostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	635 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 635	635	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000189081

Sequences

	Sequence		Length	Mass (Da)
	Q8YZ80 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 4075EA7FE7BC4411	FASTA	635	69,022
	10 20 30 40 50 60 MHLSEITHPN QLHGLSIRQL QQIARQIRDK HLQTVAEFGG HLGPGLGVVE LTLGLYQTLD 70 80 90 100 110 120 LDRDKVIWDV GHQAYPHKLI TGRYSDFHTL RQKDGIAGYL KRGENKFDHF GAGHASTSIS 130 140 150 160 170 180 AALGMALARD MNGEKFKAVA VIGDGALTGG MALEAINHAG HLPKTNLLVV LNDNEMSISP 190 200 210 220 230 240 NVGAIPRYLN KMRLSPPVQF IKDNFEEQFK HIPFVGESLS PELGRIKEGM KRLAVPKVGA 250 260 270 280 290 300 VFEELGFTYM GPVDGHNLEE LIATFQQAHQ IAGPVLVHVA TIKGKGYELA EKDQVGYHAQ 310 320 330 340 350 360 TPFNLTTGKA IPSNKPKPPA YAKVFSHTLV KLAEQNPKII GITAAMATGT GLDKLQAKLP 370 380 390 400 410 420 NQYIDVGIAE QHAVTLAAGL ATEGMRPVAA IYSTFLQRAY DQIIHDVCIQ NLPVFFCLDR 430 440 450 460 470 480 AGIVGSDGPT HQGMYDIAYL RCIPNIVMMA PKDEAEMQRM VVTGIEHTTG PIAMRFPRGN 490 500 510 520 530 540 GYGVPLMEEG WEPLEIGKGE ILRNGDDVLI IGYGTMVYPS MQAAEILSEH GIEATVINAR 550 560 570 580 590 600 FVKPLDTELI VPLAQKIGRV VTLEEGCVMG GFGSAVAEAL LDADVVVPVK RIGIPDVLVE 610 620 630 HATPDESKAE LGLTSRQIAE RVLQAYFQKQ PSPVS

References

[1]

"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7120 / UTEX 2576.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000019 Genomic DNA. Translation: BAB72557.1.
PIR	AF1881.
RefSeq	NP_484643.1. NC_003272.1.
3D structure databases
ProteinModelPortal	Q8YZ80.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8YZ80.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1104195.
GenomeReviews	Gene locus alr0599 in contig BA000019_GR.
KEGG	ana:alr0599.
NMPDR	fig|103690.1.peg.910.
PATRIC	22771004. VBINosSp37423_0990.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1154.
HOGENOM	HBG571647.
OMA	RFANEHD.
PhylomeDB	Q8YZ80.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	NSP103690:ALR0599-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. PF00456. Transketolase_N. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_NOSS1

Accession

Primary (citable) accession number: Q8YZ80

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program